| Full name: cullin 5 | Alias Symbol: VACM-1 | ||
| Type: protein-coding gene | Cytoband: 11q22.3 | ||
| Entrez ID: 8065 | HGNC ID: HGNC:2556 | Ensembl Gene: ENSG00000166266 | OMIM ID: 601741 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of CUL5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CUL5 | 8065 | 203531_at | -0.0707 | 0.8117 | |
| GSE20347 | CUL5 | 8065 | 203531_at | -0.3945 | 0.0101 | |
| GSE23400 | CUL5 | 8065 | 203531_at | -0.0001 | 0.9993 | |
| GSE26886 | CUL5 | 8065 | 203531_at | -0.5954 | 0.0480 | |
| GSE29001 | CUL5 | 8065 | 203531_at | -0.2164 | 0.3536 | |
| GSE38129 | CUL5 | 8065 | 203531_at | -0.3053 | 0.0162 | |
| GSE45670 | CUL5 | 8065 | 203531_at | -0.3184 | 0.0084 | |
| GSE53622 | CUL5 | 8065 | 35747 | -0.1907 | 0.0275 | |
| GSE53624 | CUL5 | 8065 | 35747 | -0.2013 | 0.0108 | |
| GSE63941 | CUL5 | 8065 | 203531_at | -1.0153 | 0.0847 | |
| GSE77861 | CUL5 | 8065 | 203531_at | 0.0318 | 0.9202 | |
| GSE97050 | CUL5 | 8065 | A_33_P3301286 | -0.2425 | 0.4217 | |
| SRP007169 | CUL5 | 8065 | RNAseq | -0.5307 | 0.2107 | |
| SRP008496 | CUL5 | 8065 | RNAseq | -0.0714 | 0.7644 | |
| SRP064894 | CUL5 | 8065 | RNAseq | -0.3805 | 0.0351 | |
| SRP133303 | CUL5 | 8065 | RNAseq | -0.1832 | 0.0989 | |
| SRP159526 | CUL5 | 8065 | RNAseq | -0.3537 | 0.2689 | |
| SRP193095 | CUL5 | 8065 | RNAseq | -0.6049 | 0.0000 | |
| SRP219564 | CUL5 | 8065 | RNAseq | -0.5585 | 0.0189 | |
| TCGA | CUL5 | 8065 | RNAseq | -0.1035 | 0.0322 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CUL5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CUL5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CUL5 | 8065 | 0 | 13 | 17 | |
| GSE20123 | CUL5 | 8065 | 0 | 13 | 17 | |
| GSE43470 | CUL5 | 8065 | 2 | 6 | 35 | |
| GSE46452 | CUL5 | 8065 | 3 | 26 | 30 | |
| GSE47630 | CUL5 | 8065 | 2 | 19 | 19 | |
| GSE54993 | CUL5 | 8065 | 9 | 1 | 60 | |
| GSE54994 | CUL5 | 8065 | 5 | 19 | 29 | |
| GSE60625 | CUL5 | 8065 | 0 | 3 | 8 | |
| GSE74703 | CUL5 | 8065 | 1 | 4 | 31 | |
| GSE74704 | CUL5 | 8065 | 0 | 9 | 11 | |
| TCGA | CUL5 | 8065 | 6 | 48 | 42 |
Total number of gains: 28; Total number of losses: 161; Total Number of normals: 299.
Somatic mutations of CUL5:
Generating mutation plots.
Highly correlated genes for CUL5:
Showing top 20/566 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CUL5 | AASDHPPT | 0.744844 | 9 | 0 | 9 |
| CUL5 | NHS | 0.738442 | 3 | 0 | 3 |
| CUL5 | HIBADH | 0.73776 | 3 | 0 | 3 |
| CUL5 | MRFAP1L1 | 0.734364 | 3 | 0 | 3 |
| CUL5 | TRAPPC4 | 0.727995 | 3 | 0 | 3 |
| CUL5 | RCOR3 | 0.723888 | 4 | 0 | 3 |
| CUL5 | PITPNM3 | 0.719619 | 3 | 0 | 3 |
| CUL5 | STAMBPL1 | 0.719502 | 3 | 0 | 3 |
| CUL5 | UTP14C | 0.71588 | 3 | 0 | 3 |
| CUL5 | SLC40A1 | 0.714547 | 4 | 0 | 4 |
| CUL5 | COBLL1 | 0.713476 | 3 | 0 | 3 |
| CUL5 | GMCL1 | 0.705783 | 3 | 0 | 3 |
| CUL5 | C1orf56 | 0.704945 | 3 | 0 | 3 |
| CUL5 | PTS | 0.70113 | 7 | 0 | 7 |
| CUL5 | USP45 | 0.698511 | 3 | 0 | 3 |
| CUL5 | ZBTB44 | 0.696435 | 5 | 0 | 4 |
| CUL5 | TATDN1 | 0.691637 | 3 | 0 | 3 |
| CUL5 | ERI2 | 0.68675 | 3 | 0 | 3 |
| CUL5 | LYRM7 | 0.685785 | 3 | 0 | 3 |
| CUL5 | COX7B | 0.685155 | 3 | 0 | 3 |
For details and further investigation, click here
