| Full name: solute carrier family 40 member 1 | Alias Symbol: MTP1|IREG1|FPN1|HFE4 | ||
| Type: protein-coding gene | Cytoband: 2q32.2 | ||
| Entrez ID: 30061 | HGNC ID: HGNC:10909 | Ensembl Gene: ENSG00000138449 | OMIM ID: 604653 |
| Drug and gene relationship at DGIdb | |||
Expression of SLC40A1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SLC40A1 | 30061 | 223044_at | 0.1916 | 0.7878 | |
| GSE26886 | SLC40A1 | 30061 | 223044_at | -0.7562 | 0.2455 | |
| GSE45670 | SLC40A1 | 30061 | 223044_at | -0.3318 | 0.3956 | |
| GSE53622 | SLC40A1 | 30061 | 117324 | -0.1499 | 0.3332 | |
| GSE53624 | SLC40A1 | 30061 | 101397 | -0.3675 | 0.0159 | |
| GSE63941 | SLC40A1 | 30061 | 223044_at | -4.4524 | 0.0297 | |
| GSE77861 | SLC40A1 | 30061 | 223044_at | 0.2874 | 0.6657 | |
| GSE97050 | SLC40A1 | 30061 | A_23_P102391 | -0.2848 | 0.4861 | |
| SRP007169 | SLC40A1 | 30061 | RNAseq | 0.7918 | 0.0710 | |
| SRP008496 | SLC40A1 | 30061 | RNAseq | 0.8604 | 0.0019 | |
| SRP064894 | SLC40A1 | 30061 | RNAseq | 0.1666 | 0.6071 | |
| SRP133303 | SLC40A1 | 30061 | RNAseq | -0.0171 | 0.9570 | |
| SRP159526 | SLC40A1 | 30061 | RNAseq | 1.1632 | 0.0904 | |
| SRP193095 | SLC40A1 | 30061 | RNAseq | -0.1334 | 0.7231 | |
| SRP219564 | SLC40A1 | 30061 | RNAseq | 1.2690 | 0.0154 | |
| TCGA | SLC40A1 | 30061 | RNAseq | -0.4114 | 0.0003 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by SLC40A1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SLC40A1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SLC40A1 | 30061 | 9 | 2 | 19 | |
| GSE20123 | SLC40A1 | 30061 | 9 | 2 | 19 | |
| GSE43470 | SLC40A1 | 30061 | 3 | 1 | 39 | |
| GSE46452 | SLC40A1 | 30061 | 1 | 4 | 54 | |
| GSE47630 | SLC40A1 | 30061 | 4 | 5 | 31 | |
| GSE54993 | SLC40A1 | 30061 | 0 | 5 | 65 | |
| GSE54994 | SLC40A1 | 30061 | 12 | 6 | 35 | |
| GSE60625 | SLC40A1 | 30061 | 0 | 3 | 8 | |
| GSE74703 | SLC40A1 | 30061 | 2 | 1 | 33 | |
| GSE74704 | SLC40A1 | 30061 | 3 | 2 | 15 | |
| TCGA | SLC40A1 | 30061 | 24 | 6 | 66 |
Total number of gains: 67; Total number of losses: 37; Total Number of normals: 384.
Somatic mutations of SLC40A1:
Generating mutation plots.
Highly correlated genes for SLC40A1:
Showing top 20/306 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SLC40A1 | LRRK1 | 0.767394 | 3 | 0 | 3 |
| SLC40A1 | GIMAP5 | 0.736975 | 3 | 0 | 3 |
| SLC40A1 | CLNS1A | 0.734797 | 3 | 0 | 3 |
| SLC40A1 | TBC1D8B | 0.732245 | 3 | 0 | 3 |
| SLC40A1 | ZNF573 | 0.726028 | 3 | 0 | 3 |
| SLC40A1 | CRBN | 0.71965 | 3 | 0 | 3 |
| SLC40A1 | KLHL29 | 0.717567 | 3 | 0 | 3 |
| SLC40A1 | CUL5 | 0.714547 | 4 | 0 | 4 |
| SLC40A1 | HERC2 | 0.708499 | 3 | 0 | 3 |
| SLC40A1 | ARHGAP24 | 0.703309 | 3 | 0 | 3 |
| SLC40A1 | VPS26B | 0.701818 | 3 | 0 | 3 |
| SLC40A1 | FUNDC2 | 0.699569 | 3 | 0 | 3 |
| SLC40A1 | EBF3 | 0.697096 | 3 | 0 | 3 |
| SLC40A1 | MS4A6A | 0.69675 | 6 | 0 | 6 |
| SLC40A1 | ALG8 | 0.695248 | 3 | 0 | 3 |
| SLC40A1 | NSMAF | 0.690212 | 3 | 0 | 3 |
| SLC40A1 | TM2D3 | 0.687939 | 4 | 0 | 4 |
| SLC40A1 | RHOH | 0.686653 | 3 | 0 | 3 |
| SLC40A1 | TNFRSF19 | 0.680129 | 3 | 0 | 3 |
| SLC40A1 | TMEM123 | 0.678713 | 4 | 0 | 4 |
For details and further investigation, click here
