| Full name: aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | Alias Symbol: LYS5|CGI-80|AASD-PPT|ACPS | ||
| Type: protein-coding gene | Cytoband: 11q22.3 | ||
| Entrez ID: 60496 | HGNC ID: HGNC:14235 | Ensembl Gene: ENSG00000149313 | OMIM ID: 607756 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of AASDHPPT:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AASDHPPT | 60496 | 202169_s_at | 0.0814 | 0.8664 | |
| GSE20347 | AASDHPPT | 60496 | 202169_s_at | -0.2192 | 0.2204 | |
| GSE23400 | AASDHPPT | 60496 | 202169_s_at | 0.2868 | 0.0068 | |
| GSE26886 | AASDHPPT | 60496 | 202169_s_at | -1.0684 | 0.0002 | |
| GSE29001 | AASDHPPT | 60496 | 202169_s_at | 0.1047 | 0.6571 | |
| GSE38129 | AASDHPPT | 60496 | 202169_s_at | -0.0773 | 0.6236 | |
| GSE45670 | AASDHPPT | 60496 | 202169_s_at | 0.1394 | 0.5097 | |
| GSE53622 | AASDHPPT | 60496 | 116172 | -0.1247 | 0.1792 | |
| GSE53624 | AASDHPPT | 60496 | 88103 | -0.0678 | 0.2703 | |
| GSE63941 | AASDHPPT | 60496 | 202169_s_at | -0.3379 | 0.3304 | |
| GSE77861 | AASDHPPT | 60496 | 202169_s_at | -0.0879 | 0.7553 | |
| GSE97050 | AASDHPPT | 60496 | A_23_P202988 | -0.0031 | 0.9938 | |
| SRP007169 | AASDHPPT | 60496 | RNAseq | -0.5274 | 0.1732 | |
| SRP008496 | AASDHPPT | 60496 | RNAseq | -0.3126 | 0.1373 | |
| SRP064894 | AASDHPPT | 60496 | RNAseq | -0.2058 | 0.3081 | |
| SRP133303 | AASDHPPT | 60496 | RNAseq | -0.0232 | 0.8547 | |
| SRP159526 | AASDHPPT | 60496 | RNAseq | -0.1109 | 0.6768 | |
| SRP193095 | AASDHPPT | 60496 | RNAseq | -0.5894 | 0.0000 | |
| SRP219564 | AASDHPPT | 60496 | RNAseq | 0.2677 | 0.4982 | |
| TCGA | AASDHPPT | 60496 | RNAseq | 0.0804 | 0.1208 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by AASDHPPT expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AASDHPPT:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AASDHPPT | 60496 | 0 | 13 | 17 | |
| GSE20123 | AASDHPPT | 60496 | 0 | 13 | 17 | |
| GSE43470 | AASDHPPT | 60496 | 2 | 6 | 35 | |
| GSE46452 | AASDHPPT | 60496 | 3 | 26 | 30 | |
| GSE47630 | AASDHPPT | 60496 | 2 | 19 | 19 | |
| GSE54993 | AASDHPPT | 60496 | 10 | 0 | 60 | |
| GSE54994 | AASDHPPT | 60496 | 4 | 19 | 30 | |
| GSE60625 | AASDHPPT | 60496 | 0 | 3 | 8 | |
| GSE74703 | AASDHPPT | 60496 | 1 | 4 | 31 | |
| GSE74704 | AASDHPPT | 60496 | 0 | 9 | 11 | |
| TCGA | AASDHPPT | 60496 | 7 | 48 | 41 |
Total number of gains: 29; Total number of losses: 160; Total Number of normals: 299.
Somatic mutations of AASDHPPT:
Generating mutation plots.
Highly correlated genes for AASDHPPT:
Showing top 20/394 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AASDHPPT | TMEM19 | 0.812359 | 3 | 0 | 3 |
| AASDHPPT | ATG7 | 0.778854 | 4 | 0 | 4 |
| AASDHPPT | BZW1 | 0.77235 | 3 | 0 | 3 |
| AASDHPPT | TPD52L2 | 0.760788 | 3 | 0 | 3 |
| AASDHPPT | MAP3K1 | 0.75288 | 3 | 0 | 3 |
| AASDHPPT | FAM126A | 0.752192 | 3 | 0 | 3 |
| AASDHPPT | CRLS1 | 0.751126 | 3 | 0 | 3 |
| AASDHPPT | RALGPS2 | 0.748433 | 3 | 0 | 3 |
| AASDHPPT | GINS3 | 0.747209 | 3 | 0 | 3 |
| AASDHPPT | CUL5 | 0.744844 | 9 | 0 | 9 |
| AASDHPPT | THAP2 | 0.743834 | 3 | 0 | 3 |
| AASDHPPT | DOK4 | 0.743127 | 3 | 0 | 3 |
| AASDHPPT | TMEM117 | 0.741697 | 3 | 0 | 3 |
| AASDHPPT | UNC5B | 0.737941 | 3 | 0 | 3 |
| AASDHPPT | USP45 | 0.734566 | 3 | 0 | 3 |
| AASDHPPT | MCU | 0.731672 | 3 | 0 | 3 |
| AASDHPPT | TMEM167A | 0.726565 | 4 | 0 | 3 |
| AASDHPPT | TPM3 | 0.725583 | 3 | 0 | 3 |
| AASDHPPT | CCNYL1 | 0.723214 | 3 | 0 | 3 |
| AASDHPPT | THUMPD3 | 0.722552 | 3 | 0 | 3 |
For details and further investigation, click here
