| Full name: 3-hydroxyisobutyrate dehydrogenase | Alias Symbol: NS5ATP1 | ||
| Type: protein-coding gene | Cytoband: 7p15.2 | ||
| Entrez ID: 11112 | HGNC ID: HGNC:4907 | Ensembl Gene: ENSG00000106049 | OMIM ID: 608475 |
| Drug and gene relationship at DGIdb | |||
Expression of HIBADH:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HIBADH | 11112 | 224812_at | 0.2201 | 0.7496 | |
| GSE26886 | HIBADH | 11112 | 224812_at | 1.3562 | 0.0000 | |
| GSE45670 | HIBADH | 11112 | 224812_at | -0.1776 | 0.4782 | |
| GSE53622 | HIBADH | 11112 | 38438 | 0.7170 | 0.0000 | |
| GSE53624 | HIBADH | 11112 | 38438 | 0.7927 | 0.0000 | |
| GSE63941 | HIBADH | 11112 | 224812_at | 0.0240 | 0.9712 | |
| GSE77861 | HIBADH | 11112 | 224812_at | 0.5774 | 0.2375 | |
| GSE97050 | HIBADH | 11112 | A_23_P335428 | 0.4080 | 0.2850 | |
| SRP007169 | HIBADH | 11112 | RNAseq | 0.6910 | 0.1408 | |
| SRP008496 | HIBADH | 11112 | RNAseq | 1.0335 | 0.0003 | |
| SRP064894 | HIBADH | 11112 | RNAseq | 0.1759 | 0.1328 | |
| SRP133303 | HIBADH | 11112 | RNAseq | 0.5801 | 0.0002 | |
| SRP159526 | HIBADH | 11112 | RNAseq | 0.6017 | 0.0099 | |
| SRP193095 | HIBADH | 11112 | RNAseq | 0.2144 | 0.3065 | |
| SRP219564 | HIBADH | 11112 | RNAseq | -0.0208 | 0.9725 | |
| TCGA | HIBADH | 11112 | RNAseq | -0.2110 | 0.0009 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by HIBADH expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HIBADH:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HIBADH | 11112 | 16 | 1 | 13 | |
| GSE20123 | HIBADH | 11112 | 16 | 1 | 13 | |
| GSE43470 | HIBADH | 11112 | 4 | 0 | 39 | |
| GSE46452 | HIBADH | 11112 | 10 | 2 | 47 | |
| GSE47630 | HIBADH | 11112 | 8 | 1 | 31 | |
| GSE54993 | HIBADH | 11112 | 0 | 6 | 64 | |
| GSE54994 | HIBADH | 11112 | 20 | 2 | 31 | |
| GSE60625 | HIBADH | 11112 | 0 | 0 | 11 | |
| GSE74703 | HIBADH | 11112 | 4 | 0 | 32 | |
| GSE74704 | HIBADH | 11112 | 10 | 1 | 9 | |
| TCGA | HIBADH | 11112 | 53 | 8 | 35 |
Total number of gains: 141; Total number of losses: 22; Total Number of normals: 325.
Somatic mutations of HIBADH:
Generating mutation plots.
Highly correlated genes for HIBADH:
Showing top 20/1287 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HIBADH | SLCO3A1 | 0.793279 | 3 | 0 | 3 |
| HIBADH | NPRL3 | 0.789772 | 3 | 0 | 3 |
| HIBADH | ZNF384 | 0.788929 | 3 | 0 | 3 |
| HIBADH | PIK3R3 | 0.781099 | 3 | 0 | 3 |
| HIBADH | LSM4 | 0.779333 | 3 | 0 | 3 |
| HIBADH | ZNF343 | 0.76261 | 3 | 0 | 3 |
| HIBADH | CERS2 | 0.762011 | 4 | 0 | 4 |
| HIBADH | DHRSX | 0.75931 | 3 | 0 | 3 |
| HIBADH | TCF12 | 0.757415 | 3 | 0 | 3 |
| HIBADH | MED17 | 0.757247 | 3 | 0 | 3 |
| HIBADH | TMPO | 0.745508 | 3 | 0 | 3 |
| HIBADH | POLR2G | 0.74319 | 4 | 0 | 4 |
| HIBADH | NUP35 | 0.741068 | 3 | 0 | 3 |
| HIBADH | DTYMK | 0.740295 | 3 | 0 | 3 |
| HIBADH | POMZP3 | 0.740264 | 3 | 0 | 3 |
| HIBADH | PPRC1 | 0.739317 | 4 | 0 | 3 |
| HIBADH | NR2C1 | 0.737786 | 3 | 0 | 3 |
| HIBADH | CUL5 | 0.73776 | 3 | 0 | 3 |
| HIBADH | PLEKHG2 | 0.737067 | 3 | 0 | 3 |
| HIBADH | LIN9 | 0.735706 | 4 | 0 | 4 |
For details and further investigation, click here
