CWC27

 

Full name: CWC27 spliceosome associated cyclophilin Alias Symbol: NY-CO-10|SDCCAG-10
Type: protein-coding gene Cytoband: 5q12.3
Entrez ID: 10283 HGNC ID: HGNC:10664 Ensembl Gene: ENSG00000153015 OMIM ID: 617170
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of CWC27:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CWC27 10283 1555495_a_at -0.1904 0.8421
GSE26886 CWC27 10283 1555495_a_at 0.7356 0.0026
GSE45670 CWC27 10283 1555495_a_at -0.0541 0.7401
GSE53622 CWC27 10283 71195 -0.2434 0.0004
GSE53624 CWC27 10283 71195 0.0222 0.7968
GSE63941 CWC27 10283 1555495_a_at -1.0370 0.0277
GSE77861 CWC27 10283 1555495_a_at -0.1835 0.2769
GSE97050 CWC27 10283 A_23_P92629 -0.5068 0.1726
SRP007169 CWC27 10283 RNAseq 0.2797 0.4846
SRP008496 CWC27 10283 RNAseq 0.1704 0.5606
SRP064894 CWC27 10283 RNAseq -0.0413 0.7611
SRP133303 CWC27 10283 RNAseq -0.0492 0.6942
SRP159526 CWC27 10283 RNAseq 0.1441 0.6960
SRP193095 CWC27 10283 RNAseq -0.0261 0.8509
SRP219564 CWC27 10283 RNAseq -0.3923 0.2890
TCGA CWC27 10283 RNAseq -0.0601 0.2909

Upregulated datasets: 0; Downregulated datasets: 1.  


 

Survival by CWC27 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  


Copy number change of CWC27:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CWC27 10283 0 14 16
GSE20123 CWC27 10283 0 14 16
GSE43470 CWC27 10283 1 13 29
GSE46452 CWC27 10283 0 28 31
GSE47630 CWC27 10283 2 17 21
GSE54993 CWC27 10283 8 1 61
GSE54994 CWC27 10283 1 19 33
GSE60625 CWC27 10283 0 0 11
GSE74703 CWC27 10283 1 9 26
GSE74704 CWC27 10283 0 7 13
TCGA CWC27 10283 4 50 42

Total number of gains: 17; Total number of losses: 172; Total Number of normals: 299.  


 

Somatic mutations of CWC27:

 

Generating mutation plots.

 

Highly correlated genes for CWC27:

 

Showing top 20/203 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CWC27MZT2B0.80543303
CWC27RYBP0.799548303
CWC27DDX590.779925303
CWC27SLC25A290.778232303
CWC27SSB0.750758303
CWC27SEC22A0.750239303
CWC27NAA150.748728303
CWC27UBE2V20.748091303
CWC27RPL140.744317303
CWC27SLC35E10.735546303
CWC27DNALI10.734661303
CWC27FAM204A0.729513505
CWC27PPIG0.729366403
CWC27TOMM40L0.728091303
CWC27PDHX0.725871303
CWC27EDF10.720645303
CWC27MAPK1IP1L0.720299303
CWC27PET1170.720158303
CWC27PNMA10.716412404
CWC27SRSF10.712578303

For details and further investigation, click here