| Full name: endothelial differentiation related factor 1 | Alias Symbol: EDF-1|CFAP280 | ||
| Type: protein-coding gene | Cytoband: 9q34.3 | ||
| Entrez ID: 8721 | HGNC ID: HGNC:3164 | Ensembl Gene: ENSG00000107223 | OMIM ID: 605107 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of EDF1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EDF1 | 8721 | 209058_at | -0.2968 | 0.5557 | |
| GSE20347 | EDF1 | 8721 | 209058_at | -0.6540 | 0.0000 | |
| GSE23400 | EDF1 | 8721 | 209058_at | -0.2484 | 0.0128 | |
| GSE26886 | EDF1 | 8721 | 209058_at | 0.5303 | 0.0036 | |
| GSE29001 | EDF1 | 8721 | 209058_at | -0.6517 | 0.0163 | |
| GSE38129 | EDF1 | 8721 | 209058_at | -0.4310 | 0.0000 | |
| GSE45670 | EDF1 | 8721 | 209058_at | -0.1261 | 0.3803 | |
| GSE53622 | EDF1 | 8721 | 15955 | -0.4996 | 0.0000 | |
| GSE53624 | EDF1 | 8721 | 15955 | -0.1645 | 0.0001 | |
| GSE63941 | EDF1 | 8721 | 209059_s_at | -0.2811 | 0.5042 | |
| GSE77861 | EDF1 | 8721 | 209058_at | -0.5178 | 0.0172 | |
| GSE97050 | EDF1 | 8721 | A_23_P60376 | -0.1293 | 0.6286 | |
| SRP007169 | EDF1 | 8721 | RNAseq | -1.5065 | 0.0002 | |
| SRP008496 | EDF1 | 8721 | RNAseq | -1.3647 | 0.0000 | |
| SRP064894 | EDF1 | 8721 | RNAseq | 0.1032 | 0.7876 | |
| SRP133303 | EDF1 | 8721 | RNAseq | -0.5008 | 0.0017 | |
| SRP159526 | EDF1 | 8721 | RNAseq | -0.3118 | 0.1169 | |
| SRP193095 | EDF1 | 8721 | RNAseq | -0.9386 | 0.0000 | |
| SRP219564 | EDF1 | 8721 | RNAseq | -0.3041 | 0.2723 | |
| TCGA | EDF1 | 8721 | RNAseq | -0.0298 | 0.5863 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by EDF1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EDF1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EDF1 | 8721 | 5 | 7 | 18 | |
| GSE20123 | EDF1 | 8721 | 5 | 7 | 18 | |
| GSE43470 | EDF1 | 8721 | 3 | 7 | 33 | |
| GSE46452 | EDF1 | 8721 | 6 | 13 | 40 | |
| GSE47630 | EDF1 | 8721 | 6 | 15 | 19 | |
| GSE54993 | EDF1 | 8721 | 3 | 3 | 64 | |
| GSE54994 | EDF1 | 8721 | 12 | 8 | 33 | |
| GSE60625 | EDF1 | 8721 | 0 | 0 | 11 | |
| GSE74703 | EDF1 | 8721 | 3 | 5 | 28 | |
| GSE74704 | EDF1 | 8721 | 3 | 5 | 12 | |
| TCGA | EDF1 | 8721 | 29 | 23 | 44 |
Total number of gains: 75; Total number of losses: 93; Total Number of normals: 320.
Somatic mutations of EDF1:
Generating mutation plots.
Highly correlated genes for EDF1:
Showing top 20/463 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EDF1 | ZNF223 | 0.732033 | 3 | 0 | 3 |
| EDF1 | CWC27 | 0.720645 | 3 | 0 | 3 |
| EDF1 | STRBP | 0.716599 | 3 | 0 | 3 |
| EDF1 | WDR27 | 0.700032 | 3 | 0 | 3 |
| EDF1 | NACA2 | 0.697004 | 4 | 0 | 3 |
| EDF1 | MTIF3 | 0.694537 | 5 | 0 | 5 |
| EDF1 | TMEM9B | 0.694513 | 7 | 0 | 7 |
| EDF1 | ZNF776 | 0.693759 | 3 | 0 | 3 |
| EDF1 | SLC25A27 | 0.690474 | 3 | 0 | 3 |
| EDF1 | CWC15 | 0.682046 | 4 | 0 | 4 |
| EDF1 | CCDC12 | 0.681775 | 5 | 0 | 4 |
| EDF1 | ARF6 | 0.679805 | 6 | 0 | 6 |
| EDF1 | ARGLU1 | 0.679018 | 4 | 0 | 3 |
| EDF1 | GAPVD1 | 0.676947 | 9 | 0 | 8 |
| EDF1 | FIP1L1 | 0.675255 | 4 | 0 | 3 |
| EDF1 | SON | 0.67453 | 3 | 0 | 3 |
| EDF1 | ZNF35 | 0.672566 | 3 | 0 | 3 |
| EDF1 | SAMD9 | 0.670165 | 6 | 0 | 6 |
| EDF1 | ARSD | 0.670108 | 5 | 0 | 5 |
| EDF1 | CLMN | 0.669277 | 3 | 0 | 3 |
For details and further investigation, click here
