| Full name: small RNA binding exonuclease protection factor La | Alias Symbol: LARP3|La|La/SSB | ||
| Type: protein-coding gene | Cytoband: 2q31.1 | ||
| Entrez ID: 6741 | HGNC ID: HGNC:11316 | Ensembl Gene: ENSG00000138385 | OMIM ID: 109090 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of SSB:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SSB | 6741 | 201138_s_at | 0.7693 | 0.2056 | |
| GSE20347 | SSB | 6741 | 201138_s_at | 0.8432 | 0.0000 | |
| GSE23400 | SSB | 6741 | 201138_s_at | 0.6976 | 0.0000 | |
| GSE26886 | SSB | 6741 | 201139_s_at | 1.3763 | 0.0000 | |
| GSE29001 | SSB | 6741 | 201139_s_at | 0.7873 | 0.0412 | |
| GSE38129 | SSB | 6741 | 201138_s_at | 0.8571 | 0.0000 | |
| GSE45670 | SSB | 6741 | 201138_s_at | 0.4007 | 0.0087 | |
| GSE53622 | SSB | 6741 | 22345 | 0.5841 | 0.0000 | |
| GSE53624 | SSB | 6741 | 22345 | 0.9522 | 0.0000 | |
| GSE63941 | SSB | 6741 | 201139_s_at | 0.0481 | 0.9042 | |
| GSE77861 | SSB | 6741 | 201139_s_at | 0.6938 | 0.0038 | |
| GSE97050 | SSB | 6741 | A_23_P154025 | 0.1385 | 0.6081 | |
| SRP007169 | SSB | 6741 | RNAseq | 1.3337 | 0.0022 | |
| SRP008496 | SSB | 6741 | RNAseq | 1.4181 | 0.0000 | |
| SRP064894 | SSB | 6741 | RNAseq | 0.4739 | 0.0007 | |
| SRP133303 | SSB | 6741 | RNAseq | 0.6291 | 0.0000 | |
| SRP159526 | SSB | 6741 | RNAseq | 0.6587 | 0.0008 | |
| SRP193095 | SSB | 6741 | RNAseq | 0.3626 | 0.0047 | |
| SRP219564 | SSB | 6741 | RNAseq | 0.3150 | 0.2477 | |
| TCGA | SSB | 6741 | RNAseq | 0.2090 | 0.0000 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by SSB expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SSB:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SSB | 6741 | 8 | 0 | 22 | |
| GSE20123 | SSB | 6741 | 8 | 0 | 22 | |
| GSE43470 | SSB | 6741 | 4 | 1 | 38 | |
| GSE46452 | SSB | 6741 | 1 | 4 | 54 | |
| GSE47630 | SSB | 6741 | 5 | 3 | 32 | |
| GSE54993 | SSB | 6741 | 0 | 5 | 65 | |
| GSE54994 | SSB | 6741 | 11 | 3 | 39 | |
| GSE60625 | SSB | 6741 | 0 | 3 | 8 | |
| GSE74703 | SSB | 6741 | 3 | 1 | 32 | |
| GSE74704 | SSB | 6741 | 4 | 0 | 16 | |
| TCGA | SSB | 6741 | 24 | 10 | 62 |
Total number of gains: 68; Total number of losses: 30; Total Number of normals: 390.
Somatic mutations of SSB:
Generating mutation plots.
Highly correlated genes for SSB:
Showing top 20/2013 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SSB | METTL5 | 0.805837 | 13 | 0 | 12 |
| SSB | PPP1R16A | 0.801585 | 3 | 0 | 3 |
| SSB | CBFA2T2 | 0.784296 | 3 | 0 | 3 |
| SSB | ATF7IP | 0.769194 | 3 | 0 | 3 |
| SSB | TMEM181 | 0.765908 | 4 | 0 | 4 |
| SSB | RAB34 | 0.763547 | 3 | 0 | 3 |
| SSB | ENY2 | 0.758561 | 12 | 0 | 12 |
| SSB | CCDC127 | 0.755452 | 3 | 0 | 3 |
| SSB | NOP58 | 0.751239 | 9 | 0 | 8 |
| SSB | CWC27 | 0.750758 | 3 | 0 | 3 |
| SSB | RBMX | 0.750652 | 3 | 0 | 3 |
| SSB | SLC25A32 | 0.749002 | 11 | 0 | 11 |
| SSB | HAT1 | 0.746268 | 12 | 0 | 12 |
| SSB | PYCR2 | 0.745813 | 3 | 0 | 3 |
| SSB | U2SURP | 0.741272 | 9 | 0 | 9 |
| SSB | SSRP1 | 0.739504 | 9 | 0 | 9 |
| SSB | STK3 | 0.738647 | 11 | 0 | 11 |
| SSB | OLA1 | 0.736745 | 12 | 0 | 11 |
| SSB | NF1 | 0.735583 | 3 | 0 | 3 |
| SSB | ZNF721 | 0.735354 | 4 | 0 | 4 |
For details and further investigation, click here
