| Full name: translocase of outer mitochondrial membrane 40 like | Alias Symbol: FLJ12770|TOMM40B | ||
| Type: protein-coding gene | Cytoband: 1q23.3 | ||
| Entrez ID: 84134 | HGNC ID: HGNC:25756 | Ensembl Gene: ENSG00000158882 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
TOMM40L involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05014 | Amyotrophic lateral sclerosis (ALS) |
Expression of TOMM40L:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TOMM40L | 84134 | 226059_at | 0.5219 | 0.2842 | |
| GSE26886 | TOMM40L | 84134 | 226059_at | 0.0011 | 0.9971 | |
| GSE45670 | TOMM40L | 84134 | 226059_at | 0.3823 | 0.0024 | |
| GSE63941 | TOMM40L | 84134 | 226059_at | -1.3602 | 0.0030 | |
| GSE77861 | TOMM40L | 84134 | 226059_at | 0.0607 | 0.8038 | |
| GSE97050 | TOMM40L | 84134 | A_23_P845 | -0.0917 | 0.7344 | |
| SRP007169 | TOMM40L | 84134 | RNAseq | -0.0312 | 0.9347 | |
| SRP008496 | TOMM40L | 84134 | RNAseq | -0.0504 | 0.8888 | |
| SRP064894 | TOMM40L | 84134 | RNAseq | 0.3370 | 0.0969 | |
| SRP133303 | TOMM40L | 84134 | RNAseq | 0.1561 | 0.5380 | |
| SRP159526 | TOMM40L | 84134 | RNAseq | 0.3677 | 0.1419 | |
| SRP193095 | TOMM40L | 84134 | RNAseq | -0.1397 | 0.3546 | |
| SRP219564 | TOMM40L | 84134 | RNAseq | -0.4038 | 0.3174 | |
| TCGA | TOMM40L | 84134 | RNAseq | -0.0513 | 0.4189 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by TOMM40L expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of TOMM40L:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TOMM40L | 84134 | 10 | 0 | 20 | |
| GSE20123 | TOMM40L | 84134 | 10 | 0 | 20 | |
| GSE43470 | TOMM40L | 84134 | 7 | 2 | 34 | |
| GSE46452 | TOMM40L | 84134 | 2 | 1 | 56 | |
| GSE47630 | TOMM40L | 84134 | 14 | 0 | 26 | |
| GSE54993 | TOMM40L | 84134 | 0 | 6 | 64 | |
| GSE54994 | TOMM40L | 84134 | 16 | 0 | 37 | |
| GSE60625 | TOMM40L | 84134 | 0 | 0 | 11 | |
| GSE74703 | TOMM40L | 84134 | 7 | 2 | 27 | |
| GSE74704 | TOMM40L | 84134 | 4 | 0 | 16 | |
| TCGA | TOMM40L | 84134 | 45 | 3 | 48 |
Total number of gains: 115; Total number of losses: 14; Total Number of normals: 359.
Somatic mutations of TOMM40L:
Generating mutation plots.
Highly correlated genes for TOMM40L:
Showing top 20/195 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TOMM40L | MRPL9 | 0.840231 | 3 | 0 | 3 |
| TOMM40L | MRFAP1 | 0.821502 | 3 | 0 | 3 |
| TOMM40L | DUSP23 | 0.806668 | 3 | 0 | 3 |
| TOMM40L | CCAR1 | 0.806228 | 3 | 0 | 3 |
| TOMM40L | EIF5B | 0.805221 | 3 | 0 | 3 |
| TOMM40L | GLRX2 | 0.802595 | 3 | 0 | 3 |
| TOMM40L | ZBED6 | 0.783414 | 3 | 0 | 3 |
| TOMM40L | KLHL20 | 0.780474 | 3 | 0 | 3 |
| TOMM40L | RP9 | 0.778228 | 3 | 0 | 3 |
| TOMM40L | ZMIZ2 | 0.766098 | 3 | 0 | 3 |
| TOMM40L | CSPP1 | 0.765207 | 3 | 0 | 3 |
| TOMM40L | MLEC | 0.758163 | 3 | 0 | 3 |
| TOMM40L | RBM26 | 0.758004 | 3 | 0 | 3 |
| TOMM40L | PPIG | 0.751545 | 3 | 0 | 3 |
| TOMM40L | FH | 0.748433 | 3 | 0 | 3 |
| TOMM40L | PPP6R2 | 0.74688 | 3 | 0 | 3 |
| TOMM40L | YTHDF3 | 0.746687 | 3 | 0 | 3 |
| TOMM40L | ALS2 | 0.737738 | 3 | 0 | 3 |
| TOMM40L | OSGEP | 0.737273 | 3 | 0 | 3 |
| TOMM40L | UIMC1 | 0.737193 | 3 | 0 | 3 |
For details and further investigation, click here
