| Full name: SEC22 homolog A, vesicle trafficking protein | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 3q21.1 | ||
| Entrez ID: 26984 | HGNC ID: HGNC:20260 | Ensembl Gene: ENSG00000121542 | OMIM ID: 612442 |
| Drug and gene relationship at DGIdb | |||
Expression of SEC22A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SEC22A | 26984 | 218703_at | 0.2739 | 0.2906 | |
| GSE20347 | SEC22A | 26984 | 218703_at | 0.4316 | 0.0001 | |
| GSE23400 | SEC22A | 26984 | 218703_at | 0.2211 | 0.0000 | |
| GSE26886 | SEC22A | 26984 | 218703_at | 0.6304 | 0.0001 | |
| GSE29001 | SEC22A | 26984 | 218703_at | 0.4100 | 0.1617 | |
| GSE38129 | SEC22A | 26984 | 218703_at | 0.5018 | 0.0000 | |
| GSE45670 | SEC22A | 26984 | 218703_at | 0.6558 | 0.0000 | |
| GSE53622 | SEC22A | 26984 | 41749 | 0.2445 | 0.0000 | |
| GSE53624 | SEC22A | 26984 | 41749 | 0.2183 | 0.0602 | |
| GSE63941 | SEC22A | 26984 | 218703_at | -0.2124 | 0.5228 | |
| GSE77861 | SEC22A | 26984 | 218703_at | 0.0963 | 0.7240 | |
| GSE97050 | SEC22A | 26984 | A_23_P259874 | 0.2704 | 0.3570 | |
| SRP007169 | SEC22A | 26984 | RNAseq | 0.0304 | 0.9320 | |
| SRP008496 | SEC22A | 26984 | RNAseq | 0.2447 | 0.4149 | |
| SRP064894 | SEC22A | 26984 | RNAseq | 0.4096 | 0.0295 | |
| SRP133303 | SEC22A | 26984 | RNAseq | 0.4226 | 0.0315 | |
| SRP159526 | SEC22A | 26984 | RNAseq | -0.0246 | 0.9251 | |
| SRP193095 | SEC22A | 26984 | RNAseq | 0.1674 | 0.1251 | |
| SRP219564 | SEC22A | 26984 | RNAseq | 0.0557 | 0.8517 | |
| TCGA | SEC22A | 26984 | RNAseq | 0.1214 | 0.0414 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SEC22A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SEC22A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SEC22A | 26984 | 17 | 0 | 13 | |
| GSE20123 | SEC22A | 26984 | 17 | 0 | 13 | |
| GSE43470 | SEC22A | 26984 | 20 | 0 | 23 | |
| GSE46452 | SEC22A | 26984 | 14 | 5 | 40 | |
| GSE47630 | SEC22A | 26984 | 17 | 4 | 19 | |
| GSE54993 | SEC22A | 26984 | 2 | 7 | 61 | |
| GSE54994 | SEC22A | 26984 | 30 | 4 | 19 | |
| GSE60625 | SEC22A | 26984 | 0 | 6 | 5 | |
| GSE74703 | SEC22A | 26984 | 16 | 0 | 20 | |
| GSE74704 | SEC22A | 26984 | 13 | 0 | 7 | |
| TCGA | SEC22A | 26984 | 54 | 6 | 36 |
Total number of gains: 200; Total number of losses: 32; Total Number of normals: 256.
Somatic mutations of SEC22A:
Generating mutation plots.
Highly correlated genes for SEC22A:
Showing top 20/1350 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SEC22A | PPHLN1 | 0.822162 | 3 | 0 | 3 |
| SEC22A | ZNF121 | 0.789356 | 3 | 0 | 3 |
| SEC22A | ATG12 | 0.789042 | 3 | 0 | 3 |
| SEC22A | CYB5D1 | 0.788479 | 3 | 0 | 3 |
| SEC22A | AURKAIP1 | 0.773991 | 3 | 0 | 3 |
| SEC22A | ARFGEF2 | 0.772128 | 3 | 0 | 3 |
| SEC22A | PIGK | 0.77055 | 4 | 0 | 4 |
| SEC22A | ISY1 | 0.769426 | 4 | 0 | 4 |
| SEC22A | ZNF79 | 0.767176 | 3 | 0 | 3 |
| SEC22A | MDM2 | 0.764607 | 3 | 0 | 3 |
| SEC22A | CPT1C | 0.763661 | 3 | 0 | 3 |
| SEC22A | ALKBH6 | 0.755891 | 3 | 0 | 3 |
| SEC22A | TRIM5 | 0.75565 | 3 | 0 | 3 |
| SEC22A | RPL7L1 | 0.751944 | 4 | 0 | 4 |
| SEC22A | PPIL1 | 0.751227 | 5 | 0 | 4 |
| SEC22A | CWC27 | 0.750239 | 3 | 0 | 3 |
| SEC22A | IRF2BPL | 0.747885 | 3 | 0 | 3 |
| SEC22A | KBTBD6 | 0.742155 | 3 | 0 | 3 |
| SEC22A | RRAGC | 0.741843 | 3 | 0 | 3 |
| SEC22A | DEGS1 | 0.738547 | 3 | 0 | 3 |
For details and further investigation, click here
