| Full name: family with sequence similarity 135 member B | Alias Symbol: C8ORFK32 | ||
| Type: protein-coding gene | Cytoband: 8q24.23 | ||
| Entrez ID: 51059 | HGNC ID: HGNC:28029 | Ensembl Gene: ENSG00000147724 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of FAM135B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FAM135B | 51059 | 224001_at | -0.1827 | 0.5703 | |
| GSE26886 | FAM135B | 51059 | 224001_at | -0.1614 | 0.2867 | |
| GSE45670 | FAM135B | 51059 | 224001_at | 0.0477 | 0.7098 | |
| GSE53622 | FAM135B | 51059 | 107771 | -0.9259 | 0.0000 | |
| GSE53624 | FAM135B | 51059 | 13244 | -0.4342 | 0.0339 | |
| GSE63941 | FAM135B | 51059 | 224001_at | 0.0101 | 0.9586 | |
| GSE77861 | FAM135B | 51059 | 224001_at | -0.1525 | 0.1554 | |
| TCGA | FAM135B | 51059 | RNAseq | -3.6345 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by FAM135B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FAM135B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FAM135B | 51059 | 16 | 0 | 14 | |
| GSE20123 | FAM135B | 51059 | 16 | 0 | 14 | |
| GSE43470 | FAM135B | 51059 | 23 | 1 | 19 | |
| GSE46452 | FAM135B | 51059 | 27 | 0 | 32 | |
| GSE47630 | FAM135B | 51059 | 24 | 0 | 16 | |
| GSE54993 | FAM135B | 51059 | 0 | 25 | 45 | |
| GSE54994 | FAM135B | 51059 | 39 | 1 | 13 | |
| GSE60625 | FAM135B | 51059 | 3 | 4 | 4 | |
| GSE74703 | FAM135B | 51059 | 20 | 0 | 16 | |
| GSE74704 | FAM135B | 51059 | 11 | 0 | 9 | |
| TCGA | FAM135B | 51059 | 65 | 2 | 29 |
Total number of gains: 244; Total number of losses: 33; Total Number of normals: 211.
Somatic mutations of FAM135B:
Generating mutation plots.
Highly correlated genes for FAM135B:
Showing top 20/174 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FAM135B | ANHX | 0.676786 | 3 | 0 | 3 |
| FAM135B | RHD | 0.674298 | 3 | 0 | 3 |
| FAM135B | DEFB118 | 0.655134 | 4 | 0 | 4 |
| FAM135B | TMEM253 | 0.654496 | 3 | 0 | 3 |
| FAM135B | RREB1 | 0.649762 | 3 | 0 | 3 |
| FAM135B | TMEM109 | 0.640587 | 3 | 0 | 3 |
| FAM135B | PRRX2-AS1 | 0.636592 | 3 | 0 | 3 |
| FAM135B | CST8 | 0.635817 | 3 | 0 | 3 |
| FAM135B | RAB4B | 0.634838 | 3 | 0 | 3 |
| FAM135B | ACRBP | 0.634446 | 3 | 0 | 3 |
| FAM135B | C19orf57 | 0.634236 | 3 | 0 | 3 |
| FAM135B | PLLP | 0.632627 | 3 | 0 | 3 |
| FAM135B | OR2J3 | 0.631478 | 3 | 0 | 3 |
| FAM135B | CBLN4 | 0.628612 | 4 | 0 | 3 |
| FAM135B | INSL3 | 0.626885 | 3 | 0 | 3 |
| FAM135B | TIAF1 | 0.626397 | 4 | 0 | 4 |
| FAM135B | OR4D2 | 0.62572 | 5 | 0 | 5 |
| FAM135B | CLPS | 0.62472 | 3 | 0 | 3 |
| FAM135B | PRKAR1B | 0.619567 | 3 | 0 | 3 |
| FAM135B | PACRG | 0.618445 | 3 | 0 | 3 |
For details and further investigation, click here
