| Full name: PBX/knotted 1 homeobox 2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 11q24.2 | ||
| Entrez ID: 63876 | HGNC ID: HGNC:16714 | Ensembl Gene: ENSG00000165495 | OMIM ID: 613066 |
| Drug and gene relationship at DGIdb | |||
Expression of PKNOX2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PKNOX2 | 63876 | 219046_s_at | -0.2266 | 0.4746 | |
| GSE20347 | PKNOX2 | 63876 | 219046_s_at | -0.1149 | 0.2208 | |
| GSE23400 | PKNOX2 | 63876 | 219046_s_at | -0.1610 | 0.0001 | |
| GSE26886 | PKNOX2 | 63876 | 219046_s_at | -0.1612 | 0.3118 | |
| GSE29001 | PKNOX2 | 63876 | 63305_at | -0.4881 | 0.0020 | |
| GSE38129 | PKNOX2 | 63876 | 219046_s_at | -0.4120 | 0.0002 | |
| GSE45670 | PKNOX2 | 63876 | 219046_s_at | -0.0654 | 0.6695 | |
| GSE53622 | PKNOX2 | 63876 | 68443 | -0.9064 | 0.0000 | |
| GSE53624 | PKNOX2 | 63876 | 68443 | -1.0313 | 0.0000 | |
| GSE63941 | PKNOX2 | 63876 | 219046_s_at | -0.2052 | 0.1618 | |
| GSE77861 | PKNOX2 | 63876 | 219046_s_at | -0.1626 | 0.1206 | |
| GSE97050 | PKNOX2 | 63876 | A_23_P75529 | -0.4250 | 0.2539 | |
| SRP064894 | PKNOX2 | 63876 | RNAseq | -0.7105 | 0.0667 | |
| SRP133303 | PKNOX2 | 63876 | RNAseq | -1.6365 | 0.0008 | |
| SRP159526 | PKNOX2 | 63876 | RNAseq | -0.2066 | 0.6986 | |
| SRP219564 | PKNOX2 | 63876 | RNAseq | -0.1403 | 0.8766 | |
| TCGA | PKNOX2 | 63876 | RNAseq | -1.2290 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by PKNOX2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PKNOX2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PKNOX2 | 63876 | 0 | 13 | 17 | |
| GSE20123 | PKNOX2 | 63876 | 0 | 13 | 17 | |
| GSE43470 | PKNOX2 | 63876 | 2 | 7 | 34 | |
| GSE46452 | PKNOX2 | 63876 | 3 | 26 | 30 | |
| GSE47630 | PKNOX2 | 63876 | 2 | 19 | 19 | |
| GSE54993 | PKNOX2 | 63876 | 10 | 0 | 60 | |
| GSE54994 | PKNOX2 | 63876 | 5 | 19 | 29 | |
| GSE60625 | PKNOX2 | 63876 | 0 | 3 | 8 | |
| GSE74703 | PKNOX2 | 63876 | 1 | 5 | 30 | |
| GSE74704 | PKNOX2 | 63876 | 0 | 9 | 11 | |
| TCGA | PKNOX2 | 63876 | 6 | 50 | 40 |
Total number of gains: 29; Total number of losses: 164; Total Number of normals: 295.
Somatic mutations of PKNOX2:
Generating mutation plots.
Highly correlated genes for PKNOX2:
Showing top 20/961 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PKNOX2 | CLK3 | 0.76096 | 3 | 0 | 3 |
| PKNOX2 | GABRR2 | 0.746218 | 5 | 0 | 5 |
| PKNOX2 | FBLN1 | 0.738008 | 3 | 0 | 3 |
| PKNOX2 | NFIA | 0.727453 | 3 | 0 | 3 |
| PKNOX2 | LDOC1 | 0.724293 | 4 | 0 | 4 |
| PKNOX2 | LINC01119 | 0.715753 | 3 | 0 | 3 |
| PKNOX2 | NOTCH4 | 0.71123 | 3 | 0 | 3 |
| PKNOX2 | TGFB1I1 | 0.709882 | 3 | 0 | 3 |
| PKNOX2 | BEND5 | 0.708708 | 3 | 0 | 3 |
| PKNOX2 | PHLDB1 | 0.695443 | 7 | 0 | 7 |
| PKNOX2 | SCGB1D2 | 0.694881 | 3 | 0 | 3 |
| PKNOX2 | PPM1D | 0.694745 | 3 | 0 | 3 |
| PKNOX2 | BVES | 0.688239 | 3 | 0 | 3 |
| PKNOX2 | CLEC14A | 0.684696 | 4 | 0 | 3 |
| PKNOX2 | KCNQ3 | 0.683734 | 6 | 0 | 5 |
| PKNOX2 | THYN1 | 0.682685 | 3 | 0 | 3 |
| PKNOX2 | LIN7A | 0.679753 | 4 | 0 | 4 |
| PKNOX2 | MYOCD | 0.67949 | 3 | 0 | 3 |
| PKNOX2 | PDLIM2 | 0.677447 | 4 | 0 | 4 |
| PKNOX2 | CDC14A | 0.677124 | 6 | 0 | 6 |
For details and further investigation, click here
