DENND1A

 

Full name: DENN domain containing 1A Alias Symbol: FLJ21129|FAM31A
Type: protein-coding gene Cytoband: 9q33.3
Entrez ID: 57706 HGNC ID: HGNC:29324 Ensembl Gene: ENSG00000119522 OMIM ID: 613633
Drug and gene relationship at DGIdb

 

Expression of DENND1A:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 DENND1A 57706 226849_at 0.0028 0.9966
GSE20347 DENND1A 57706 219763_at 0.8104 0.0040
GSE23400 DENND1A 57706 219763_at 0.3268 0.0001
GSE26886 DENND1A 57706 226849_at 0.7434 0.0043
GSE29001 DENND1A 57706 219763_at 1.2879 0.0025
GSE38129 DENND1A 57706 219763_at 0.7695 0.0001
GSE45670 DENND1A 57706 226849_at 0.0340 0.8384
GSE53622 DENND1A 57706 48989 0.1954 0.0060
GSE53624 DENND1A 57706 48989 0.7377 0.0000
GSE63941 DENND1A 57706 226849_at 0.3029 0.4951
GSE77861 DENND1A 57706 226849_at 0.2762 0.0908
GSE97050 DENND1A 57706 A_23_P43557 0.0509 0.8409
SRP007169 DENND1A 57706 RNAseq 0.9467 0.0270
SRP008496 DENND1A 57706 RNAseq 0.7386 0.0117
SRP064894 DENND1A 57706 RNAseq 0.7289 0.0002
SRP133303 DENND1A 57706 RNAseq 0.2356 0.0136
SRP159526 DENND1A 57706 RNAseq 0.6534 0.0000
SRP193095 DENND1A 57706 RNAseq 0.3634 0.0219
SRP219564 DENND1A 57706 RNAseq 0.3608 0.4502
TCGA DENND1A 57706 RNAseq -0.0854 0.0937

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by DENND1A expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of DENND1A:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 DENND1A 57706 4 8 18
GSE20123 DENND1A 57706 4 8 18
GSE43470 DENND1A 57706 5 5 33
GSE46452 DENND1A 57706 6 13 40
GSE47630 DENND1A 57706 3 16 21
GSE54993 DENND1A 57706 3 3 64
GSE54994 DENND1A 57706 10 9 34
GSE60625 DENND1A 57706 0 0 11
GSE74703 DENND1A 57706 5 3 28
GSE74704 DENND1A 57706 2 6 12
TCGA DENND1A 57706 27 24 45

Total number of gains: 69; Total number of losses: 95; Total Number of normals: 324.  

 

Somatic mutations of DENND1A:

 

Generating mutation plots.

 

Highly correlated genes for DENND1A:

 

Showing top 20/814 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
DENND1AASB70.80069303
DENND1AFAM200B0.793224303
DENND1ATMSB15B0.757783303
DENND1AZNF7040.748702303
DENND1ADYNC1H10.745378303
DENND1ASPEN0.743489303
DENND1AMRPS60.743215303
DENND1AGTPBP60.742336303
DENND1AKLF120.73731303
DENND1AZNF3190.725635303
DENND1ACLSPN0.725244303
DENND1ASDHAF20.720621303
DENND1ASCMH10.711538403
DENND1AZSCAN210.71025403
DENND1AEFCAB70.709844303
DENND1ABCL7B0.709565404
DENND1ACCDC970.703889303
DENND1AZNF6410.702238303
DENND1APTPN60.698069303
DENND1AFAM43B0.69642303

For details and further investigation, click here