| Full name: protein tyrosine phosphatase non-receptor type 6 | Alias Symbol: HCP|HCPH|PTP-1C|SHP-1|SHP1 | ||
| Type: protein-coding gene | Cytoband: 12p13.31 | ||
| Entrez ID: 5777 | HGNC ID: HGNC:9658 | Ensembl Gene: ENSG00000111679 | OMIM ID: 176883 |
| Drug and gene relationship at DGIdb | |||
PTPN6 involved pathways:
Expression of PTPN6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PTPN6 | 5777 | 206687_s_at | 0.6288 | 0.2312 | |
| GSE20347 | PTPN6 | 5777 | 206687_s_at | 0.3210 | 0.0124 | |
| GSE23400 | PTPN6 | 5777 | 206687_s_at | 0.4239 | 0.0000 | |
| GSE26886 | PTPN6 | 5777 | 206687_s_at | 0.5320 | 0.0516 | |
| GSE29001 | PTPN6 | 5777 | 206687_s_at | 0.3771 | 0.0597 | |
| GSE38129 | PTPN6 | 5777 | 206687_s_at | 0.2874 | 0.0549 | |
| GSE45670 | PTPN6 | 5777 | 206687_s_at | 0.3473 | 0.0119 | |
| GSE53622 | PTPN6 | 5777 | 44249 | 0.4706 | 0.0001 | |
| GSE53624 | PTPN6 | 5777 | 44249 | 0.3487 | 0.0000 | |
| GSE63941 | PTPN6 | 5777 | 206687_s_at | 2.0205 | 0.0008 | |
| GSE77861 | PTPN6 | 5777 | 206687_s_at | 0.3591 | 0.0447 | |
| GSE97050 | PTPN6 | 5777 | A_23_P162486 | 1.0065 | 0.1189 | |
| SRP007169 | PTPN6 | 5777 | RNAseq | 0.7899 | 0.1006 | |
| SRP008496 | PTPN6 | 5777 | RNAseq | 0.6657 | 0.0296 | |
| SRP064894 | PTPN6 | 5777 | RNAseq | 0.7425 | 0.0027 | |
| SRP133303 | PTPN6 | 5777 | RNAseq | 0.1358 | 0.5968 | |
| SRP159526 | PTPN6 | 5777 | RNAseq | -0.1939 | 0.6806 | |
| SRP193095 | PTPN6 | 5777 | RNAseq | 0.3006 | 0.0118 | |
| SRP219564 | PTPN6 | 5777 | RNAseq | 1.1119 | 0.0192 | |
| TCGA | PTPN6 | 5777 | RNAseq | 0.2637 | 0.0005 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by PTPN6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PTPN6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PTPN6 | 5777 | 9 | 3 | 18 | |
| GSE20123 | PTPN6 | 5777 | 9 | 3 | 18 | |
| GSE43470 | PTPN6 | 5777 | 8 | 3 | 32 | |
| GSE46452 | PTPN6 | 5777 | 10 | 1 | 48 | |
| GSE47630 | PTPN6 | 5777 | 12 | 2 | 26 | |
| GSE54993 | PTPN6 | 5777 | 1 | 10 | 59 | |
| GSE54994 | PTPN6 | 5777 | 10 | 2 | 41 | |
| GSE60625 | PTPN6 | 5777 | 0 | 1 | 10 | |
| GSE74703 | PTPN6 | 5777 | 7 | 2 | 27 | |
| GSE74704 | PTPN6 | 5777 | 5 | 3 | 12 | |
| TCGA | PTPN6 | 5777 | 40 | 6 | 50 |
Total number of gains: 111; Total number of losses: 36; Total Number of normals: 341.
Somatic mutations of PTPN6:
Generating mutation plots.
Highly correlated genes for PTPN6:
Showing top 20/1143 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PTPN6 | KLHDC3 | 0.768274 | 3 | 0 | 3 |
| PTPN6 | ARF3 | 0.757829 | 3 | 0 | 3 |
| PTPN6 | SNAI3 | 0.754499 | 3 | 0 | 3 |
| PTPN6 | RPS15 | 0.743664 | 3 | 0 | 3 |
| PTPN6 | PPP1CA | 0.738501 | 3 | 0 | 3 |
| PTPN6 | ZBED1 | 0.726498 | 4 | 0 | 4 |
| PTPN6 | DUS3L | 0.722462 | 4 | 0 | 4 |
| PTPN6 | SLC25A19 | 0.719761 | 4 | 0 | 4 |
| PTPN6 | DGCR2 | 0.719133 | 3 | 0 | 3 |
| PTPN6 | GAL | 0.717609 | 3 | 0 | 3 |
| PTPN6 | SCAF1 | 0.715114 | 3 | 0 | 3 |
| PTPN6 | RNF166 | 0.713423 | 4 | 0 | 3 |
| PTPN6 | FBXL19 | 0.709958 | 3 | 0 | 3 |
| PTPN6 | ERICH1 | 0.705522 | 3 | 0 | 3 |
| PTPN6 | KIAA1324L | 0.704744 | 3 | 0 | 3 |
| PTPN6 | HIGD2A | 0.701326 | 4 | 0 | 3 |
| PTPN6 | CNOT10 | 0.699154 | 3 | 0 | 3 |
| PTPN6 | PRRC2A | 0.698115 | 3 | 0 | 3 |
| PTPN6 | DENND1A | 0.698069 | 3 | 0 | 3 |
| PTPN6 | SCML4 | 0.692837 | 3 | 0 | 3 |
For details and further investigation, click here
