| Full name: succinate dehydrogenase complex assembly factor 2 | Alias Symbol: FLJ20487|SDH5 | ||
| Type: protein-coding gene | Cytoband: 11q12.2 | ||
| Entrez ID: 54949 | HGNC ID: HGNC:26034 | Ensembl Gene: ENSG00000167985 | OMIM ID: 613019 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of SDHAF2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SDHAF2 | 54949 | 223048_at | 0.2389 | 0.4475 | |
| GSE26886 | SDHAF2 | 54949 | 223048_at | 0.7123 | 0.0019 | |
| GSE45670 | SDHAF2 | 54949 | 223048_at | 0.1318 | 0.3588 | |
| GSE53622 | SDHAF2 | 54949 | 17032 | 0.1787 | 0.0027 | |
| GSE53624 | SDHAF2 | 54949 | 17032 | 0.2051 | 0.0141 | |
| GSE63941 | SDHAF2 | 54949 | 223048_at | 0.6967 | 0.0842 | |
| GSE77861 | SDHAF2 | 54949 | 223048_at | 0.5684 | 0.0016 | |
| GSE97050 | SDHAF2 | 54949 | A_23_P1926 | 0.2389 | 0.2729 | |
| SRP007169 | SDHAF2 | 54949 | RNAseq | -0.3101 | 0.3883 | |
| SRP008496 | SDHAF2 | 54949 | RNAseq | -0.3214 | 0.1921 | |
| SRP064894 | SDHAF2 | 54949 | RNAseq | -0.0580 | 0.7687 | |
| SRP133303 | SDHAF2 | 54949 | RNAseq | 0.1412 | 0.3829 | |
| SRP159526 | SDHAF2 | 54949 | RNAseq | 0.2038 | 0.2077 | |
| SRP193095 | SDHAF2 | 54949 | RNAseq | -0.1980 | 0.0410 | |
| SRP219564 | SDHAF2 | 54949 | RNAseq | -0.0153 | 0.9624 | |
| TCGA | SDHAF2 | 54949 | RNAseq | 0.0516 | 0.3256 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SDHAF2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SDHAF2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SDHAF2 | 54949 | 4 | 5 | 21 | |
| GSE20123 | SDHAF2 | 54949 | 4 | 5 | 21 | |
| GSE43470 | SDHAF2 | 54949 | 2 | 6 | 35 | |
| GSE46452 | SDHAF2 | 54949 | 8 | 4 | 47 | |
| GSE47630 | SDHAF2 | 54949 | 3 | 8 | 29 | |
| GSE54993 | SDHAF2 | 54949 | 3 | 0 | 67 | |
| GSE54994 | SDHAF2 | 54949 | 5 | 5 | 43 | |
| GSE60625 | SDHAF2 | 54949 | 0 | 3 | 8 | |
| GSE74703 | SDHAF2 | 54949 | 2 | 3 | 31 | |
| GSE74704 | SDHAF2 | 54949 | 3 | 3 | 14 | |
| TCGA | SDHAF2 | 54949 | 15 | 10 | 71 |
Total number of gains: 49; Total number of losses: 52; Total Number of normals: 387.
Somatic mutations of SDHAF2:
Generating mutation plots.
Highly correlated genes for SDHAF2:
Showing top 20/962 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SDHAF2 | ZDHHC7 | 0.811093 | 3 | 0 | 3 |
| SDHAF2 | SLC25A24 | 0.809256 | 3 | 0 | 3 |
| SDHAF2 | RAP1B | 0.802198 | 3 | 0 | 3 |
| SDHAF2 | ALCAM | 0.799728 | 3 | 0 | 3 |
| SDHAF2 | GPATCH2 | 0.795302 | 3 | 0 | 3 |
| SDHAF2 | ERP29 | 0.793608 | 3 | 0 | 3 |
| SDHAF2 | LPCAT1 | 0.78594 | 3 | 0 | 3 |
| SDHAF2 | HCCS | 0.779945 | 3 | 0 | 3 |
| SDHAF2 | L3MBTL3 | 0.761853 | 3 | 0 | 3 |
| SDHAF2 | CLP1 | 0.761677 | 7 | 0 | 7 |
| SDHAF2 | LRRC59 | 0.760058 | 4 | 0 | 3 |
| SDHAF2 | POLA1 | 0.760042 | 3 | 0 | 3 |
| SDHAF2 | NFE2L1 | 0.759536 | 3 | 0 | 3 |
| SDHAF2 | KTI12 | 0.759111 | 3 | 0 | 3 |
| SDHAF2 | SMAD1 | 0.75902 | 3 | 0 | 3 |
| SDHAF2 | RIN2 | 0.758415 | 3 | 0 | 3 |
| SDHAF2 | MAGOHB | 0.754749 | 3 | 0 | 3 |
| SDHAF2 | CERS5 | 0.754326 | 3 | 0 | 3 |
| SDHAF2 | MILR1 | 0.751255 | 3 | 0 | 3 |
| SDHAF2 | CLEC12A | 0.74886 | 3 | 0 | 3 |
For details and further investigation, click here
