| Full name: dynein cytoplasmic 1 heavy chain 1 | Alias Symbol: Dnchc1|HL-3|p22|DHC1|CMT2O | ||
| Type: protein-coding gene | Cytoband: 14q32.31 | ||
| Entrez ID: 1778 | HGNC ID: HGNC:2961 | Ensembl Gene: ENSG00000197102 | OMIM ID: 600112 |
| Drug and gene relationship at DGIdb | |||
Expression of DYNC1H1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DYNC1H1 | 1778 | 211928_at | 0.7487 | 0.0424 | |
| GSE20347 | DYNC1H1 | 1778 | 211928_at | 0.2082 | 0.1030 | |
| GSE23400 | DYNC1H1 | 1778 | 211928_at | 0.5206 | 0.0000 | |
| GSE26886 | DYNC1H1 | 1778 | 211928_at | 1.2507 | 0.0000 | |
| GSE29001 | DYNC1H1 | 1778 | 211928_at | 0.2541 | 0.3313 | |
| GSE38129 | DYNC1H1 | 1778 | 211928_at | 0.2093 | 0.0528 | |
| GSE45670 | DYNC1H1 | 1778 | 211928_at | 0.3722 | 0.0062 | |
| GSE53622 | DYNC1H1 | 1778 | 17506 | 0.4926 | 0.0000 | |
| GSE53624 | DYNC1H1 | 1778 | 17506 | 0.7124 | 0.0000 | |
| GSE63941 | DYNC1H1 | 1778 | 211928_at | -0.6153 | 0.0987 | |
| GSE77861 | DYNC1H1 | 1778 | 211928_at | 0.7746 | 0.0907 | |
| GSE97050 | DYNC1H1 | 1778 | A_23_P128706 | 0.2758 | 0.3186 | |
| SRP007169 | DYNC1H1 | 1778 | RNAseq | 2.5946 | 0.0000 | |
| SRP008496 | DYNC1H1 | 1778 | RNAseq | 2.1885 | 0.0000 | |
| SRP064894 | DYNC1H1 | 1778 | RNAseq | 0.5607 | 0.0000 | |
| SRP133303 | DYNC1H1 | 1778 | RNAseq | 0.5320 | 0.0001 | |
| SRP159526 | DYNC1H1 | 1778 | RNAseq | 0.7399 | 0.0719 | |
| SRP193095 | DYNC1H1 | 1778 | RNAseq | 0.6958 | 0.0000 | |
| SRP219564 | DYNC1H1 | 1778 | RNAseq | 0.2518 | 0.5028 | |
| TCGA | DYNC1H1 | 1778 | RNAseq | -0.0054 | 0.9105 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by DYNC1H1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DYNC1H1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DYNC1H1 | 1778 | 11 | 5 | 14 | |
| GSE20123 | DYNC1H1 | 1778 | 10 | 4 | 16 | |
| GSE43470 | DYNC1H1 | 1778 | 7 | 4 | 32 | |
| GSE46452 | DYNC1H1 | 1778 | 18 | 4 | 37 | |
| GSE47630 | DYNC1H1 | 1778 | 10 | 9 | 21 | |
| GSE54993 | DYNC1H1 | 1778 | 3 | 8 | 59 | |
| GSE54994 | DYNC1H1 | 1778 | 21 | 4 | 28 | |
| GSE60625 | DYNC1H1 | 1778 | 0 | 2 | 9 | |
| GSE74703 | DYNC1H1 | 1778 | 6 | 3 | 27 | |
| GSE74704 | DYNC1H1 | 1778 | 5 | 3 | 12 | |
| TCGA | DYNC1H1 | 1778 | 32 | 19 | 45 |
Total number of gains: 123; Total number of losses: 65; Total Number of normals: 300.
Somatic mutations of DYNC1H1:
Generating mutation plots.
Highly correlated genes for DYNC1H1:
Showing top 20/1477 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DYNC1H1 | TP53I13 | 0.752109 | 6 | 0 | 6 |
| DYNC1H1 | WDR54 | 0.751804 | 7 | 0 | 7 |
| DYNC1H1 | C15orf61 | 0.749967 | 3 | 0 | 3 |
| DYNC1H1 | DENND1A | 0.745378 | 3 | 0 | 3 |
| DYNC1H1 | ZBED1 | 0.741566 | 4 | 0 | 4 |
| DYNC1H1 | ZC3H12C | 0.728544 | 3 | 0 | 3 |
| DYNC1H1 | EBNA1BP2 | 0.726598 | 3 | 0 | 3 |
| DYNC1H1 | XPR1 | 0.720467 | 7 | 0 | 7 |
| DYNC1H1 | AKT1 | 0.717928 | 11 | 0 | 10 |
| DYNC1H1 | PLEKHG2 | 0.717338 | 3 | 0 | 3 |
| DYNC1H1 | ZNF706 | 0.716071 | 3 | 0 | 3 |
| DYNC1H1 | RAB34 | 0.711053 | 3 | 0 | 3 |
| DYNC1H1 | SLC46A1 | 0.711037 | 4 | 0 | 4 |
| DYNC1H1 | SIVA1 | 0.708975 | 12 | 0 | 11 |
| DYNC1H1 | ZSCAN21 | 0.708833 | 4 | 0 | 3 |
| DYNC1H1 | SCNM1 | 0.703028 | 3 | 0 | 3 |
| DYNC1H1 | CAD | 0.700573 | 8 | 0 | 8 |
| DYNC1H1 | TTC7B | 0.699886 | 7 | 0 | 6 |
| DYNC1H1 | SH3PXD2B | 0.699713 | 8 | 0 | 7 |
| DYNC1H1 | IMP4 | 0.699535 | 8 | 0 | 7 |
For details and further investigation, click here
