| Full name: mitochondrial ribosomal protein S6 | Alias Symbol: MRP-S6|RPMS6 | ||
| Type: protein-coding gene | Cytoband: 21q22.11 | ||
| Entrez ID: 64968 | HGNC ID: HGNC:14051 | Ensembl Gene: ENSG00000243927 | OMIM ID: 611973 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of MRPS6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MRPS6 | 64968 | 224919_at | 0.5902 | 0.0900 | |
| GSE26886 | MRPS6 | 64968 | 224919_at | 0.8318 | 0.0048 | |
| GSE45670 | MRPS6 | 64968 | 224919_at | 0.4351 | 0.0499 | |
| GSE53622 | MRPS6 | 64968 | 39788 | 0.2146 | 0.0010 | |
| GSE53624 | MRPS6 | 64968 | 39788 | 0.7222 | 0.0000 | |
| GSE63941 | MRPS6 | 64968 | 224919_at | 0.3420 | 0.3997 | |
| GSE77861 | MRPS6 | 64968 | 224919_at | 0.3057 | 0.1801 | |
| GSE97050 | MRPS6 | 64968 | A_23_P102890 | -0.1405 | 0.6772 | |
| SRP007169 | MRPS6 | 64968 | RNAseq | 0.2547 | 0.6132 | |
| SRP008496 | MRPS6 | 64968 | RNAseq | 0.0959 | 0.7833 | |
| SRP064894 | MRPS6 | 64968 | RNAseq | 0.6750 | 0.0081 | |
| SRP133303 | MRPS6 | 64968 | RNAseq | 0.6467 | 0.0000 | |
| SRP159526 | MRPS6 | 64968 | RNAseq | 0.4479 | 0.0450 | |
| SRP193095 | MRPS6 | 64968 | RNAseq | 0.5022 | 0.0004 | |
| SRP219564 | MRPS6 | 64968 | RNAseq | 0.3143 | 0.5119 | |
| TCGA | MRPS6 | 64968 | RNAseq | 0.1239 | 0.0626 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MRPS6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MRPS6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MRPS6 | 64968 | 2 | 7 | 21 | |
| GSE20123 | MRPS6 | 64968 | 2 | 8 | 20 | |
| GSE43470 | MRPS6 | 64968 | 1 | 11 | 31 | |
| GSE46452 | MRPS6 | 64968 | 1 | 21 | 37 | |
| GSE47630 | MRPS6 | 64968 | 6 | 17 | 17 | |
| GSE54993 | MRPS6 | 64968 | 9 | 1 | 60 | |
| GSE54994 | MRPS6 | 64968 | 1 | 9 | 43 | |
| GSE60625 | MRPS6 | 64968 | 0 | 0 | 11 | |
| GSE74703 | MRPS6 | 64968 | 1 | 8 | 27 | |
| GSE74704 | MRPS6 | 64968 | 1 | 4 | 15 | |
| TCGA | MRPS6 | 64968 | 8 | 37 | 51 |
Total number of gains: 32; Total number of losses: 123; Total Number of normals: 333.
Somatic mutations of MRPS6:
Generating mutation plots.
Highly correlated genes for MRPS6:
Showing top 20/1323 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MRPS6 | C20orf194 | 0.80784 | 3 | 0 | 3 |
| MRPS6 | GATAD2B | 0.800652 | 4 | 0 | 4 |
| MRPS6 | RNASEH2B | 0.798766 | 3 | 0 | 3 |
| MRPS6 | POGK | 0.795789 | 3 | 0 | 3 |
| MRPS6 | HMGB1 | 0.794087 | 4 | 0 | 4 |
| MRPS6 | ANKRD17 | 0.792251 | 3 | 0 | 3 |
| MRPS6 | PAIP1 | 0.791175 | 3 | 0 | 3 |
| MRPS6 | RNF115 | 0.787329 | 3 | 0 | 3 |
| MRPS6 | ABL1 | 0.772821 | 3 | 0 | 3 |
| MRPS6 | RLIM | 0.766339 | 3 | 0 | 3 |
| MRPS6 | UBQLN4 | 0.765783 | 4 | 0 | 4 |
| MRPS6 | NSUN3 | 0.760936 | 3 | 0 | 3 |
| MRPS6 | MOAP1 | 0.759515 | 3 | 0 | 3 |
| MRPS6 | GGPS1 | 0.758977 | 3 | 0 | 3 |
| MRPS6 | CBX5 | 0.755925 | 3 | 0 | 3 |
| MRPS6 | TADA1 | 0.754943 | 3 | 0 | 3 |
| MRPS6 | POLR1B | 0.752063 | 3 | 0 | 3 |
| MRPS6 | COX6C | 0.750098 | 3 | 0 | 3 |
| MRPS6 | TARDBP | 0.749562 | 4 | 0 | 4 |
| MRPS6 | SFMBT1 | 0.749474 | 3 | 0 | 3 |
For details and further investigation, click here
