| Full name: spen family transcriptional repressor | Alias Symbol: KIAA0929|MINT|SHARP|RBM15C | ||
| Type: protein-coding gene | Cytoband: 1p36.21-p36.13 | ||
| Entrez ID: 23013 | HGNC ID: HGNC:17575 | Ensembl Gene: ENSG00000065526 | OMIM ID: 613484 |
| Drug and gene relationship at DGIdb | |||
Expression of SPEN:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SPEN | 23013 | 201997_s_at | 0.3775 | 0.2516 | |
| GSE20347 | SPEN | 23013 | 201997_s_at | 0.3314 | 0.0045 | |
| GSE23400 | SPEN | 23013 | 201997_s_at | 0.3981 | 0.0000 | |
| GSE26886 | SPEN | 23013 | 201997_s_at | 0.7000 | 0.0002 | |
| GSE29001 | SPEN | 23013 | 201997_s_at | 0.4452 | 0.0095 | |
| GSE38129 | SPEN | 23013 | 201997_s_at | 0.3583 | 0.0001 | |
| GSE45670 | SPEN | 23013 | 201997_s_at | 0.2664 | 0.0298 | |
| GSE53622 | SPEN | 23013 | 136858 | 0.0791 | 0.1103 | |
| GSE53624 | SPEN | 23013 | 136858 | 0.2102 | 0.0000 | |
| GSE63941 | SPEN | 23013 | 201997_s_at | 0.7465 | 0.0217 | |
| GSE77861 | SPEN | 23013 | 201997_s_at | 0.2208 | 0.2999 | |
| GSE97050 | SPEN | 23013 | A_33_P3347417 | 0.0211 | 0.9340 | |
| SRP007169 | SPEN | 23013 | RNAseq | 1.2735 | 0.0129 | |
| SRP008496 | SPEN | 23013 | RNAseq | 1.4037 | 0.0001 | |
| SRP064894 | SPEN | 23013 | RNAseq | -0.1799 | 0.5567 | |
| SRP133303 | SPEN | 23013 | RNAseq | 0.1849 | 0.0129 | |
| SRP159526 | SPEN | 23013 | RNAseq | 0.0378 | 0.8540 | |
| SRP193095 | SPEN | 23013 | RNAseq | 0.3843 | 0.0011 | |
| SRP219564 | SPEN | 23013 | RNAseq | -0.3647 | 0.3100 | |
| TCGA | SPEN | 23013 | RNAseq | 0.0346 | 0.3954 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by SPEN expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SPEN:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPEN | 23013 | 1 | 5 | 24 | |
| GSE20123 | SPEN | 23013 | 1 | 4 | 25 | |
| GSE43470 | SPEN | 23013 | 1 | 8 | 34 | |
| GSE46452 | SPEN | 23013 | 7 | 1 | 51 | |
| GSE47630 | SPEN | 23013 | 8 | 3 | 29 | |
| GSE54993 | SPEN | 23013 | 3 | 1 | 66 | |
| GSE54994 | SPEN | 23013 | 10 | 4 | 39 | |
| GSE60625 | SPEN | 23013 | 0 | 0 | 11 | |
| GSE74703 | SPEN | 23013 | 1 | 5 | 30 | |
| GSE74704 | SPEN | 23013 | 1 | 0 | 19 | |
| TCGA | SPEN | 23013 | 12 | 24 | 60 |
Total number of gains: 45; Total number of losses: 55; Total Number of normals: 388.
Somatic mutations of SPEN:
Generating mutation plots.
Highly correlated genes for SPEN:
Showing top 20/1136 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPEN | RPL7L1 | 0.837806 | 3 | 0 | 3 |
| SPEN | PIK3R3 | 0.807963 | 3 | 0 | 3 |
| SPEN | COMMD7 | 0.80544 | 3 | 0 | 3 |
| SPEN | UHRF1BP1 | 0.801212 | 3 | 0 | 3 |
| SPEN | GNPAT | 0.796005 | 3 | 0 | 3 |
| SPEN | ZNF251 | 0.7834 | 3 | 0 | 3 |
| SPEN | CLDN12 | 0.775359 | 3 | 0 | 3 |
| SPEN | LMLN | 0.764818 | 3 | 0 | 3 |
| SPEN | ASB7 | 0.764023 | 3 | 0 | 3 |
| SPEN | ARID2 | 0.757229 | 3 | 0 | 3 |
| SPEN | SH2B1 | 0.756075 | 3 | 0 | 3 |
| SPEN | SCAF1 | 0.755598 | 3 | 0 | 3 |
| SPEN | DMAP1 | 0.751556 | 3 | 0 | 3 |
| SPEN | DENND1A | 0.743489 | 3 | 0 | 3 |
| SPEN | SCAND1 | 0.740996 | 3 | 0 | 3 |
| SPEN | TPCN2 | 0.739464 | 3 | 0 | 3 |
| SPEN | RAD18 | 0.737768 | 3 | 0 | 3 |
| SPEN | SPSB2 | 0.736184 | 3 | 0 | 3 |
| SPEN | PRR12 | 0.73315 | 4 | 0 | 3 |
| SPEN | PDHA1 | 0.732441 | 3 | 0 | 3 |
For details and further investigation, click here
