| Full name: diacylglycerol O-acyltransferase 1 | Alias Symbol: ARGP1 | ||
| Type: protein-coding gene | Cytoband: 8q24.3 | ||
| Entrez ID: 8694 | HGNC ID: HGNC:2843 | Ensembl Gene: ENSG00000185000 | OMIM ID: 604900 |
| Drug and gene relationship at DGIdb | |||
Expression of DGAT1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DGAT1 | 8694 | 203669_s_at | 0.5114 | 0.2785 | |
| GSE20347 | DGAT1 | 8694 | 203669_s_at | -0.3495 | 0.0186 | |
| GSE23400 | DGAT1 | 8694 | 203669_s_at | -0.2485 | 0.0007 | |
| GSE26886 | DGAT1 | 8694 | 203669_s_at | -0.6585 | 0.0108 | |
| GSE29001 | DGAT1 | 8694 | 203669_s_at | -0.6053 | 0.0561 | |
| GSE38129 | DGAT1 | 8694 | 203669_s_at | -0.3165 | 0.0150 | |
| GSE45670 | DGAT1 | 8694 | 203669_s_at | 0.1391 | 0.3221 | |
| GSE53622 | DGAT1 | 8694 | 21907 | -0.2760 | 0.0034 | |
| GSE53624 | DGAT1 | 8694 | 21907 | -0.3160 | 0.0000 | |
| GSE63941 | DGAT1 | 8694 | 203669_s_at | 0.4856 | 0.4233 | |
| GSE77861 | DGAT1 | 8694 | 203669_s_at | -0.3980 | 0.0712 | |
| GSE97050 | DGAT1 | 8694 | A_33_P3271990 | 0.1218 | 0.6194 | |
| SRP007169 | DGAT1 | 8694 | RNAseq | -1.8678 | 0.0000 | |
| SRP008496 | DGAT1 | 8694 | RNAseq | -1.5054 | 0.0000 | |
| SRP064894 | DGAT1 | 8694 | RNAseq | 0.0794 | 0.7736 | |
| SRP133303 | DGAT1 | 8694 | RNAseq | -0.2828 | 0.0895 | |
| SRP159526 | DGAT1 | 8694 | RNAseq | -0.2285 | 0.2301 | |
| SRP193095 | DGAT1 | 8694 | RNAseq | -0.6869 | 0.0078 | |
| SRP219564 | DGAT1 | 8694 | RNAseq | 0.2706 | 0.6334 | |
| TCGA | DGAT1 | 8694 | RNAseq | -0.0207 | 0.7279 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by DGAT1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DGAT1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DGAT1 | 8694 | 17 | 1 | 12 | |
| GSE20123 | DGAT1 | 8694 | 17 | 1 | 12 | |
| GSE43470 | DGAT1 | 8694 | 16 | 2 | 25 | |
| GSE46452 | DGAT1 | 8694 | 28 | 0 | 31 | |
| GSE47630 | DGAT1 | 8694 | 25 | 1 | 14 | |
| GSE54993 | DGAT1 | 8694 | 0 | 25 | 45 | |
| GSE54994 | DGAT1 | 8694 | 39 | 1 | 13 | |
| GSE60625 | DGAT1 | 8694 | 3 | 4 | 4 | |
| GSE74703 | DGAT1 | 8694 | 14 | 1 | 21 | |
| GSE74704 | DGAT1 | 8694 | 10 | 0 | 10 | |
| TCGA | DGAT1 | 8694 | 63 | 2 | 31 |
Total number of gains: 232; Total number of losses: 38; Total Number of normals: 218.
Somatic mutations of DGAT1:
Generating mutation plots.
Highly correlated genes for DGAT1:
Showing top 20/255 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DGAT1 | WDR37 | 0.742041 | 3 | 0 | 3 |
| DGAT1 | EIF4H | 0.716733 | 3 | 0 | 3 |
| DGAT1 | SGSH | 0.706011 | 3 | 0 | 3 |
| DGAT1 | DAB2IP | 0.687302 | 3 | 0 | 3 |
| DGAT1 | COPS5 | 0.678012 | 3 | 0 | 3 |
| DGAT1 | ATP2A2 | 0.668931 | 3 | 0 | 3 |
| DGAT1 | EXOC3L4 | 0.663621 | 3 | 0 | 3 |
| DGAT1 | MAP4K4 | 0.662879 | 3 | 0 | 3 |
| DGAT1 | GPAA1 | 0.652702 | 5 | 0 | 4 |
| DGAT1 | B9D2 | 0.646924 | 3 | 0 | 3 |
| DGAT1 | UBTD1 | 0.642842 | 3 | 0 | 3 |
| DGAT1 | RNF4 | 0.636747 | 4 | 0 | 3 |
| DGAT1 | NAA15 | 0.636653 | 3 | 0 | 3 |
| DGAT1 | SUSD2 | 0.635448 | 3 | 0 | 3 |
| DGAT1 | GORASP2 | 0.631773 | 4 | 0 | 3 |
| DGAT1 | TATDN2 | 0.630584 | 3 | 0 | 3 |
| DGAT1 | SUFU | 0.627895 | 4 | 0 | 4 |
| DGAT1 | GRINA | 0.626992 | 3 | 0 | 3 |
| DGAT1 | TRAPPC2 | 0.624237 | 3 | 0 | 3 |
| DGAT1 | SYCP2 | 0.620367 | 3 | 0 | 3 |
For details and further investigation, click here
