| Full name: glycosylphosphatidylinositol anchor attachment 1 | Alias Symbol: GAA1|hGAA1 | ||
| Type: protein-coding gene | Cytoband: 8q24.3 | ||
| Entrez ID: 8733 | HGNC ID: HGNC:4446 | Ensembl Gene: ENSG00000197858 | OMIM ID: 603048 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of GPAA1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GPAA1 | 8733 | 215690_x_at | 0.7729 | 0.1081 | |
| GSE20347 | GPAA1 | 8733 | 215690_x_at | 0.0664 | 0.5952 | |
| GSE23400 | GPAA1 | 8733 | 215690_x_at | 0.3022 | 0.0000 | |
| GSE26886 | GPAA1 | 8733 | 215690_x_at | 0.0674 | 0.7141 | |
| GSE29001 | GPAA1 | 8733 | 215690_x_at | 0.2593 | 0.0949 | |
| GSE38129 | GPAA1 | 8733 | 215690_x_at | 0.1644 | 0.0533 | |
| GSE45670 | GPAA1 | 8733 | 215690_x_at | 0.3769 | 0.0002 | |
| GSE53622 | GPAA1 | 8733 | 21670 | 0.2334 | 0.0009 | |
| GSE53624 | GPAA1 | 8733 | 104818 | 0.4067 | 0.0000 | |
| GSE63941 | GPAA1 | 8733 | 215690_x_at | 0.2972 | 0.5116 | |
| GSE77861 | GPAA1 | 8733 | 215690_x_at | -0.0384 | 0.8681 | |
| GSE97050 | GPAA1 | 8733 | A_23_P147383 | 0.3839 | 0.2862 | |
| SRP007169 | GPAA1 | 8733 | RNAseq | -1.3263 | 0.0003 | |
| SRP008496 | GPAA1 | 8733 | RNAseq | -1.1569 | 0.0000 | |
| SRP064894 | GPAA1 | 8733 | RNAseq | 0.8313 | 0.0073 | |
| SRP133303 | GPAA1 | 8733 | RNAseq | 0.1506 | 0.4045 | |
| SRP159526 | GPAA1 | 8733 | RNAseq | 0.2767 | 0.2993 | |
| SRP193095 | GPAA1 | 8733 | RNAseq | 0.2796 | 0.0293 | |
| SRP219564 | GPAA1 | 8733 | RNAseq | 0.5073 | 0.1984 | |
| TCGA | GPAA1 | 8733 | RNAseq | -0.0013 | 0.9776 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by GPAA1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GPAA1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GPAA1 | 8733 | 17 | 1 | 12 | |
| GSE20123 | GPAA1 | 8733 | 17 | 1 | 12 | |
| GSE43470 | GPAA1 | 8733 | 16 | 2 | 25 | |
| GSE46452 | GPAA1 | 8733 | 27 | 0 | 32 | |
| GSE47630 | GPAA1 | 8733 | 23 | 1 | 16 | |
| GSE54993 | GPAA1 | 8733 | 0 | 25 | 45 | |
| GSE54994 | GPAA1 | 8733 | 39 | 1 | 13 | |
| GSE60625 | GPAA1 | 8733 | 3 | 4 | 4 | |
| GSE74703 | GPAA1 | 8733 | 14 | 1 | 21 | |
| GSE74704 | GPAA1 | 8733 | 10 | 0 | 10 | |
| TCGA | GPAA1 | 8733 | 63 | 2 | 31 |
Total number of gains: 229; Total number of losses: 38; Total Number of normals: 221.
Somatic mutations of GPAA1:
Generating mutation plots.
Highly correlated genes for GPAA1:
Showing top 20/813 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GPAA1 | QSOX2 | 0.797098 | 3 | 0 | 3 |
| GPAA1 | PDCD5 | 0.740491 | 3 | 0 | 3 |
| GPAA1 | HNRNPUL1 | 0.735949 | 3 | 0 | 3 |
| GPAA1 | CXCL16 | 0.73186 | 3 | 0 | 3 |
| GPAA1 | GOSR2 | 0.730361 | 3 | 0 | 3 |
| GPAA1 | DHX37 | 0.722186 | 4 | 0 | 4 |
| GPAA1 | CCDC85C | 0.721706 | 4 | 0 | 3 |
| GPAA1 | B3GALT6 | 0.720791 | 5 | 0 | 4 |
| GPAA1 | U2AF2 | 0.719023 | 5 | 0 | 5 |
| GPAA1 | CACNA1B | 0.716197 | 3 | 0 | 3 |
| GPAA1 | ZNF581 | 0.714967 | 4 | 0 | 4 |
| GPAA1 | PPP6R1 | 0.714413 | 4 | 0 | 4 |
| GPAA1 | LSAMP-AS1 | 0.712386 | 3 | 0 | 3 |
| GPAA1 | FAM90A1 | 0.70848 | 3 | 0 | 3 |
| GPAA1 | ZAP70 | 0.695223 | 3 | 0 | 3 |
| GPAA1 | CDCA2 | 0.695147 | 3 | 0 | 3 |
| GPAA1 | ZNF362 | 0.690915 | 3 | 0 | 3 |
| GPAA1 | MRPL55 | 0.690209 | 4 | 0 | 4 |
| GPAA1 | ZNF713 | 0.689486 | 3 | 0 | 3 |
| GPAA1 | MRPL14 | 0.689295 | 4 | 0 | 4 |
For details and further investigation, click here
