| Full name: SUFU negative regulator of hedgehog signaling | Alias Symbol: SUFUH|SUFUXL|PRO1280 | ||
| Type: protein-coding gene | Cytoband: 10q24.32 | ||
| Entrez ID: 51684 | HGNC ID: HGNC:16466 | Ensembl Gene: ENSG00000107882 | OMIM ID: 607035 |
| Drug and gene relationship at DGIdb | |||
SUFU involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04340 | Hedgehog signaling pathway | |
| hsa05200 | Pathways in cancer |
Expression of SUFU:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SUFU | 51684 | 222749_at | -0.0072 | 0.9840 | |
| GSE26886 | SUFU | 51684 | 222749_at | -0.2154 | 0.2322 | |
| GSE45670 | SUFU | 51684 | 222749_at | -0.1416 | 0.2356 | |
| GSE53622 | SUFU | 51684 | 158800 | -0.1127 | 0.0670 | |
| GSE53624 | SUFU | 51684 | 31347 | -0.1707 | 0.0058 | |
| GSE63941 | SUFU | 51684 | 222749_at | -0.9409 | 0.0014 | |
| GSE77861 | SUFU | 51684 | 222749_at | -0.2842 | 0.0702 | |
| GSE97050 | SUFU | 51684 | A_33_P3333030 | 0.2689 | 0.4077 | |
| SRP007169 | SUFU | 51684 | RNAseq | -1.3279 | 0.0003 | |
| SRP008496 | SUFU | 51684 | RNAseq | -0.9585 | 0.0015 | |
| SRP064894 | SUFU | 51684 | RNAseq | -0.1621 | 0.2255 | |
| SRP133303 | SUFU | 51684 | RNAseq | -0.3727 | 0.0569 | |
| SRP159526 | SUFU | 51684 | RNAseq | -0.6161 | 0.0464 | |
| SRP193095 | SUFU | 51684 | RNAseq | -0.1369 | 0.3241 | |
| SRP219564 | SUFU | 51684 | RNAseq | 0.0555 | 0.8291 | |
| TCGA | SUFU | 51684 | RNAseq | 0.0292 | 0.6008 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by SUFU expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SUFU:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SUFU | 51684 | 2 | 9 | 19 | |
| GSE20123 | SUFU | 51684 | 2 | 8 | 20 | |
| GSE43470 | SUFU | 51684 | 0 | 8 | 35 | |
| GSE46452 | SUFU | 51684 | 0 | 11 | 48 | |
| GSE47630 | SUFU | 51684 | 2 | 14 | 24 | |
| GSE54993 | SUFU | 51684 | 8 | 0 | 62 | |
| GSE54994 | SUFU | 51684 | 1 | 11 | 41 | |
| GSE60625 | SUFU | 51684 | 0 | 0 | 11 | |
| GSE74703 | SUFU | 51684 | 0 | 5 | 31 | |
| GSE74704 | SUFU | 51684 | 1 | 4 | 15 | |
| TCGA | SUFU | 51684 | 5 | 29 | 62 |
Total number of gains: 21; Total number of losses: 99; Total Number of normals: 368.
Somatic mutations of SUFU:
Generating mutation plots.
Highly correlated genes for SUFU:
Showing top 20/373 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SUFU | SSNA1 | 0.772863 | 3 | 0 | 3 |
| SUFU | RABEP2 | 0.76655 | 4 | 0 | 4 |
| SUFU | C1orf122 | 0.755726 | 3 | 0 | 3 |
| SUFU | TRPV2 | 0.743643 | 3 | 0 | 3 |
| SUFU | SLC44A4 | 0.742784 | 3 | 0 | 3 |
| SUFU | RUNDC1 | 0.742775 | 3 | 0 | 3 |
| SUFU | B9D2 | 0.741428 | 3 | 0 | 3 |
| SUFU | TUFM | 0.733521 | 3 | 0 | 3 |
| SUFU | RINT1 | 0.732817 | 3 | 0 | 3 |
| SUFU | C16orf58 | 0.730663 | 3 | 0 | 3 |
| SUFU | ALDH18A1 | 0.729747 | 3 | 0 | 3 |
| SUFU | PODN | 0.729447 | 3 | 0 | 3 |
| SUFU | USP47 | 0.728919 | 3 | 0 | 3 |
| SUFU | MCM3AP | 0.727167 | 3 | 0 | 3 |
| SUFU | PSD3 | 0.719244 | 3 | 0 | 3 |
| SUFU | ELL | 0.718994 | 3 | 0 | 3 |
| SUFU | ARCN1 | 0.718635 | 3 | 0 | 3 |
| SUFU | HIC2 | 0.717394 | 3 | 0 | 3 |
| SUFU | KIAA0556 | 0.717046 | 4 | 0 | 3 |
| SUFU | ARHGEF6 | 0.715918 | 3 | 0 | 3 |
For details and further investigation, click here
