MAP4K4

 

Full name: mitogen-activated protein kinase kinase kinase kinase 4 Alias Symbol: HGK|NIK|FLH21957
Type: protein-coding gene Cytoband: 2q11.2
Entrez ID: 9448 HGNC ID: HGNC:6866 Ensembl Gene: ENSG00000071054 OMIM ID: 604666
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

MAP4K4 involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway

 

Expression of MAP4K4:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 MAP4K4 9448 206571_s_at 0.8550 0.0827
GSE20347 MAP4K4 9448 206571_s_at -0.1127 0.5791
GSE23400 MAP4K4 9448 206571_s_at 0.2891 0.0016
GSE26886 MAP4K4 9448 206571_s_at -0.8497 0.0073
GSE29001 MAP4K4 9448 206571_s_at -0.2253 0.5411
GSE38129 MAP4K4 9448 206571_s_at 0.3012 0.0467
GSE45670 MAP4K4 9448 206571_s_at 0.6428 0.0037
GSE53622 MAP4K4 9448 40265 0.0170 0.8585
GSE53624 MAP4K4 9448 40265 0.2671 0.0062
GSE63941 MAP4K4 9448 206571_s_at -1.8739 0.0040
GSE77861 MAP4K4 9448 206571_s_at 0.3364 0.2612
GSE97050 MAP4K4 9448 A_23_P90804 0.2380 0.2850
SRP007169 MAP4K4 9448 RNAseq 0.6722 0.1285
SRP008496 MAP4K4 9448 RNAseq 0.7353 0.0073
SRP064894 MAP4K4 9448 RNAseq 0.4194 0.0091
SRP133303 MAP4K4 9448 RNAseq 0.5775 0.0008
SRP159526 MAP4K4 9448 RNAseq 0.2429 0.4484
SRP193095 MAP4K4 9448 RNAseq 0.4436 0.0164
SRP219564 MAP4K4 9448 RNAseq -0.0833 0.8298
TCGA MAP4K4 9448 RNAseq 0.2121 0.0000

Upregulated datasets: 0; Downregulated datasets: 1.  

 

Survival by MAP4K4 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of MAP4K4:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 MAP4K4 9448 5 2 23
GSE20123 MAP4K4 9448 5 2 23
GSE43470 MAP4K4 9448 5 1 37
GSE46452 MAP4K4 9448 1 4 54
GSE47630 MAP4K4 9448 7 0 33
GSE54993 MAP4K4 9448 0 6 64
GSE54994 MAP4K4 9448 11 0 42
GSE60625 MAP4K4 9448 0 3 8
GSE74703 MAP4K4 9448 5 1 30
GSE74704 MAP4K4 9448 3 1 16
TCGA MAP4K4 9448 35 6 55

Total number of gains: 77; Total number of losses: 26; Total Number of normals: 385.  

 

Somatic mutations of MAP4K4:

 

Generating mutation plots.

 

Highly correlated genes for MAP4K4:

 

Showing top 20/512 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
MAP4K4CIAO10.815046303
MAP4K4NUDT50.807759303
MAP4K4GPD20.784701303
MAP4K4MKNK10.776405303
MAP4K4ALG20.76252303
MAP4K4DCAF130.760222303
MAP4K4TRADD0.7564303
MAP4K4MASTL0.753022303
MAP4K4STC20.750786404
MAP4K4BDKRB10.749923303
MAP4K4TPM30.747174404
MAP4K4TERF2IP0.740508303
MAP4K4C11orf240.739638404
MAP4K4CDC42SE10.738759303
MAP4K4IRF2BPL0.737466303
MAP4K4TP53I110.736556303
MAP4K4IFFO20.736481303
MAP4K4ERLEC10.736409303
MAP4K4ATG70.736238303
MAP4K4BMP2K0.733493303

For details and further investigation, click here