| Full name: N-sulfoglucosamine sulfohydrolase | Alias Symbol: HSS|MPS3A|SFMD | ||
| Type: protein-coding gene | Cytoband: 17q25.3 | ||
| Entrez ID: 6448 | HGNC ID: HGNC:10818 | Ensembl Gene: ENSG00000181523 | OMIM ID: 605270 |
| Drug and gene relationship at DGIdb | |||
Expression of SGSH:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SGSH | 6448 | 35626_at | 0.2959 | 0.3765 | |
| GSE20347 | SGSH | 6448 | 35626_at | -0.1001 | 0.5686 | |
| GSE23400 | SGSH | 6448 | 35626_at | 0.0387 | 0.6321 | |
| GSE26886 | SGSH | 6448 | 35626_at | -0.7264 | 0.0088 | |
| GSE29001 | SGSH | 6448 | 35626_at | 0.0521 | 0.9165 | |
| GSE38129 | SGSH | 6448 | 35626_at | -0.1992 | 0.1090 | |
| GSE45670 | SGSH | 6448 | 35626_at | -0.0077 | 0.9496 | |
| GSE63941 | SGSH | 6448 | 35626_at | -1.9771 | 0.0060 | |
| GSE77861 | SGSH | 6448 | 35626_at | 0.0919 | 0.6940 | |
| GSE97050 | SGSH | 6448 | A_23_P254254 | 0.2441 | 0.3411 | |
| SRP007169 | SGSH | 6448 | RNAseq | -0.3164 | 0.4321 | |
| SRP008496 | SGSH | 6448 | RNAseq | -0.3224 | 0.2738 | |
| SRP064894 | SGSH | 6448 | RNAseq | 0.5670 | 0.0025 | |
| SRP133303 | SGSH | 6448 | RNAseq | -0.2712 | 0.1340 | |
| SRP159526 | SGSH | 6448 | RNAseq | 0.0202 | 0.9386 | |
| SRP193095 | SGSH | 6448 | RNAseq | 0.2032 | 0.1617 | |
| SRP219564 | SGSH | 6448 | RNAseq | 0.0830 | 0.7463 | |
| TCGA | SGSH | 6448 | RNAseq | -0.1457 | 0.0197 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by SGSH expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of SGSH:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SGSH | 6448 | 4 | 3 | 23 | |
| GSE20123 | SGSH | 6448 | 4 | 3 | 23 | |
| GSE43470 | SGSH | 6448 | 3 | 5 | 35 | |
| GSE46452 | SGSH | 6448 | 34 | 0 | 25 | |
| GSE47630 | SGSH | 6448 | 9 | 1 | 30 | |
| GSE54993 | SGSH | 6448 | 2 | 5 | 63 | |
| GSE54994 | SGSH | 6448 | 10 | 6 | 37 | |
| GSE60625 | SGSH | 6448 | 6 | 0 | 5 | |
| GSE74703 | SGSH | 6448 | 3 | 3 | 30 | |
| GSE74704 | SGSH | 6448 | 4 | 3 | 13 | |
| TCGA | SGSH | 6448 | 28 | 10 | 58 |
Total number of gains: 107; Total number of losses: 39; Total Number of normals: 342.
Somatic mutations of SGSH:
Generating mutation plots.
Highly correlated genes for SGSH:
Showing top 20/247 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SGSH | RNASEH2B | 0.822515 | 3 | 0 | 3 |
| SGSH | SF3A2 | 0.811726 | 3 | 0 | 3 |
| SGSH | U2AF2 | 0.807669 | 3 | 0 | 3 |
| SGSH | UXS1 | 0.790205 | 3 | 0 | 3 |
| SGSH | TSEN34 | 0.787566 | 3 | 0 | 3 |
| SGSH | RRP1B | 0.783356 | 3 | 0 | 3 |
| SGSH | XRN1 | 0.781694 | 3 | 0 | 3 |
| SGSH | CUEDC1 | 0.774269 | 3 | 0 | 3 |
| SGSH | RASA2 | 0.773896 | 3 | 0 | 3 |
| SGSH | RNF4 | 0.77048 | 3 | 0 | 3 |
| SGSH | MTHFR | 0.769823 | 3 | 0 | 3 |
| SGSH | HGS | 0.763048 | 5 | 0 | 4 |
| SGSH | HYOU1 | 0.754188 | 3 | 0 | 3 |
| SGSH | PRDM15 | 0.752319 | 3 | 0 | 3 |
| SGSH | LACTB | 0.75182 | 3 | 0 | 3 |
| SGSH | DPP9 | 0.751598 | 3 | 0 | 3 |
| SGSH | WDFY1 | 0.750873 | 3 | 0 | 3 |
| SGSH | GOLGA3 | 0.748813 | 4 | 0 | 4 |
| SGSH | OCEL1 | 0.743417 | 3 | 0 | 3 |
| SGSH | AKAP17A | 0.741932 | 3 | 0 | 3 |
For details and further investigation, click here
