| Full name: eukaryotic translation initiation factor 4H | Alias Symbol: WSCR1|KIAA0038 | ||
| Type: protein-coding gene | Cytoband: 7q11.23 | ||
| Entrez ID: 7458 | HGNC ID: HGNC:12741 | Ensembl Gene: ENSG00000106682 | OMIM ID: 603431 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of EIF4H:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EIF4H | 7458 | 206621_s_at | 0.2004 | 0.2662 | |
| GSE20347 | EIF4H | 7458 | 206621_s_at | -0.0065 | 0.9670 | |
| GSE23400 | EIF4H | 7458 | 206621_s_at | 0.0584 | 0.3113 | |
| GSE26886 | EIF4H | 7458 | 206621_s_at | -0.5808 | 0.0055 | |
| GSE29001 | EIF4H | 7458 | 206621_s_at | -0.2314 | 0.4463 | |
| GSE38129 | EIF4H | 7458 | 206621_s_at | 0.0177 | 0.8698 | |
| GSE45670 | EIF4H | 7458 | 206621_s_at | 0.0501 | 0.5766 | |
| GSE53622 | EIF4H | 7458 | 32337 | -0.0019 | 0.9774 | |
| GSE53624 | EIF4H | 7458 | 32337 | 0.1071 | 0.0474 | |
| GSE63941 | EIF4H | 7458 | 206621_s_at | 0.2877 | 0.2205 | |
| GSE77861 | EIF4H | 7458 | 206621_s_at | 0.0340 | 0.8159 | |
| GSE97050 | EIF4H | A_21_P0013292 | -0.1966 | 0.4322 | ||
| SRP007169 | EIF4H | 7458 | RNAseq | -1.1126 | 0.0001 | |
| SRP008496 | EIF4H | 7458 | RNAseq | -0.9542 | 0.0000 | |
| SRP064894 | EIF4H | 7458 | RNAseq | -0.4217 | 0.0025 | |
| SRP133303 | EIF4H | 7458 | RNAseq | 0.1191 | 0.3940 | |
| SRP159526 | EIF4H | 7458 | RNAseq | -0.3470 | 0.0238 | |
| SRP193095 | EIF4H | 7458 | RNAseq | -0.0975 | 0.4404 | |
| SRP219564 | EIF4H | 7458 | RNAseq | -0.2448 | 0.2596 | |
| TCGA | EIF4H | 7458 | RNAseq | 0.0030 | 0.9395 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by EIF4H expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EIF4H:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EIF4H | 7458 | 14 | 1 | 15 | |
| GSE20123 | EIF4H | 7458 | 14 | 1 | 15 | |
| GSE43470 | EIF4H | 7458 | 3 | 2 | 38 | |
| GSE46452 | EIF4H | 7458 | 12 | 0 | 47 | |
| GSE47630 | EIF4H | 7458 | 7 | 2 | 31 | |
| GSE54993 | EIF4H | 7458 | 2 | 7 | 61 | |
| GSE54994 | EIF4H | 7458 | 13 | 3 | 37 | |
| GSE60625 | EIF4H | 7458 | 0 | 0 | 11 | |
| GSE74703 | EIF4H | 7458 | 3 | 1 | 32 | |
| GSE74704 | EIF4H | 7458 | 8 | 1 | 11 | |
| TCGA | EIF4H | 7458 | 45 | 7 | 44 |
Total number of gains: 121; Total number of losses: 25; Total Number of normals: 342.
Somatic mutations of EIF4H:
Generating mutation plots.
Highly correlated genes for EIF4H:
Showing top 20/183 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EIF4H | PMVK | 0.768945 | 3 | 0 | 3 |
| EIF4H | PPARGC1B | 0.748582 | 3 | 0 | 3 |
| EIF4H | LEPROT | 0.729143 | 3 | 0 | 3 |
| EIF4H | DGAT1 | 0.716733 | 3 | 0 | 3 |
| EIF4H | DHTKD1 | 0.685755 | 3 | 0 | 3 |
| EIF4H | PRPF38A | 0.685569 | 3 | 0 | 3 |
| EIF4H | KHK | 0.685068 | 3 | 0 | 3 |
| EIF4H | RPS3 | 0.682782 | 3 | 0 | 3 |
| EIF4H | SNX12 | 0.671755 | 3 | 0 | 3 |
| EIF4H | TP53RK | 0.658234 | 3 | 0 | 3 |
| EIF4H | TNKS2 | 0.654541 | 4 | 0 | 3 |
| EIF4H | SETX | 0.650687 | 3 | 0 | 3 |
| EIF4H | IDH2 | 0.647638 | 4 | 0 | 4 |
| EIF4H | RBM15B | 0.639413 | 3 | 0 | 3 |
| EIF4H | MFSD3 | 0.637088 | 3 | 0 | 3 |
| EIF4H | TRIP12 | 0.635059 | 4 | 0 | 3 |
| EIF4H | CEBPA | 0.634714 | 4 | 0 | 3 |
| EIF4H | RAB3D | 0.625404 | 3 | 0 | 3 |
| EIF4H | ZCCHC9 | 0.623189 | 4 | 0 | 3 |
| EIF4H | ELMO2 | 0.623162 | 3 | 0 | 3 |
For details and further investigation, click here
