ATP2A2

 

Full name: ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 Alias Symbol: SERCA2
Type: protein-coding gene Cytoband: 12q24.11
Entrez ID: 488 HGNC ID: HGNC:812 Ensembl Gene: ENSG00000174437 OMIM ID: 108740
Drug and gene relationship at DGIdb

 

ATP2A2 involved pathways:

KEGG pathway Description View
hsa04020Calcium signaling pathway
hsa04022cGMP-PKG signaling pathway
hsa04261Adrenergic signaling in cardiomyocytes
hsa04919Thyroid hormone signaling pathway

 

Expression of ATP2A2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ATP2A2 488 209186_at 0.6853 0.1009
GSE20347 ATP2A2 488 209186_at 0.1976 0.2149
GSE23400 ATP2A2 488 209186_at 0.3596 0.0000
GSE26886 ATP2A2 488 212361_s_at -0.3795 0.2833
GSE29001 ATP2A2 488 209186_at -0.0292 0.8973
GSE38129 ATP2A2 488 209186_at 0.6178 0.0075
GSE45670 ATP2A2 488 209186_at 0.5700 0.0000
GSE53622 ATP2A2 488 63672 0.4021 0.0000
GSE53624 ATP2A2 488 63672 0.2756 0.0000
GSE63941 ATP2A2 488 209186_at 1.1514 0.0003
GSE77861 ATP2A2 488 209186_at 0.2385 0.3049
GSE97050 ATP2A2 488 A_24_P141786 0.3660 0.1479
SRP007169 ATP2A2 488 RNAseq 0.3200 0.3333
SRP008496 ATP2A2 488 RNAseq -0.0107 0.9581
SRP064894 ATP2A2 488 RNAseq -0.3186 0.2405
SRP133303 ATP2A2 488 RNAseq 0.2534 0.0702
SRP159526 ATP2A2 488 RNAseq 0.1971 0.5835
SRP193095 ATP2A2 488 RNAseq 0.2743 0.0129
SRP219564 ATP2A2 488 RNAseq -0.2955 0.4500
TCGA ATP2A2 488 RNAseq 0.1135 0.0023

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by ATP2A2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ATP2A2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ATP2A2 488 5 3 22
GSE20123 ATP2A2 488 5 3 22
GSE43470 ATP2A2 488 2 1 40
GSE46452 ATP2A2 488 9 1 49
GSE47630 ATP2A2 488 9 3 28
GSE54993 ATP2A2 488 0 5 65
GSE54994 ATP2A2 488 4 3 46
GSE60625 ATP2A2 488 0 0 11
GSE74703 ATP2A2 488 2 0 34
GSE74704 ATP2A2 488 2 2 16
TCGA ATP2A2 488 22 10 64

Total number of gains: 60; Total number of losses: 31; Total Number of normals: 397.  

 

Somatic mutations of ATP2A2:

 

Generating mutation plots.

 

Highly correlated genes for ATP2A2:

 

Showing top 20/442 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ATP2A2KDF10.702235404
ATP2A2CAPN150.699508404
ATP2A2RCC20.697025606
ATP2A2CMTM40.692003303
ATP2A2NAA500.68444606
ATP2A2ADAM150.675516303
ATP2A2BTF3L40.674865404
ATP2A2LINC010000.672273303
ATP2A2MARVELD20.668957303
ATP2A2DGAT10.668931303
ATP2A2FUOM0.668305303
ATP2A2STXBP20.666848504
ATP2A2CNOT30.661909404
ATP2A2PPP1R350.659812303
ATP2A2TRIM290.658996303
ATP2A2TADA2A0.650192303
ATP2A2WDR180.647873706
ATP2A2EIF4G10.64486806
ATP2A2CCDC1370.641754403
ATP2A2CDK160.639561503

For details and further investigation, click here