| Full name: COP9 signalosome subunit 5 | Alias Symbol: JAB1|SGN5|MOV-34|CSN5 | ||
| Type: protein-coding gene | Cytoband: 8q13.1 | ||
| Entrez ID: 10987 | HGNC ID: HGNC:2240 | Ensembl Gene: ENSG00000121022 | OMIM ID: 604850 |
| Drug and gene relationship at DGIdb | |||
Expression of COPS5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | COPS5 | 10987 | 201652_at | 0.4615 | 0.2708 | |
| GSE20347 | COPS5 | 10987 | 201652_at | 0.3681 | 0.0199 | |
| GSE23400 | COPS5 | 10987 | 201652_at | 0.3639 | 0.0000 | |
| GSE26886 | COPS5 | 10987 | 201652_at | -0.3942 | 0.0278 | |
| GSE29001 | COPS5 | 10987 | 201652_at | 0.2863 | 0.4116 | |
| GSE38129 | COPS5 | 10987 | 201652_at | 0.4086 | 0.0008 | |
| GSE45670 | COPS5 | 10987 | 201652_at | 0.2854 | 0.0270 | |
| GSE53622 | COPS5 | 10987 | 69738 | 0.2194 | 0.0001 | |
| GSE53624 | COPS5 | 10987 | 69738 | 0.5232 | 0.0000 | |
| GSE63941 | COPS5 | 10987 | 201652_at | 0.1518 | 0.6827 | |
| GSE77861 | COPS5 | 10987 | 201652_at | 0.0295 | 0.9413 | |
| GSE97050 | COPS5 | 10987 | A_23_P71419 | 0.1195 | 0.6862 | |
| SRP007169 | COPS5 | 10987 | RNAseq | -0.4623 | 0.1666 | |
| SRP008496 | COPS5 | 10987 | RNAseq | -0.4558 | 0.0076 | |
| SRP064894 | COPS5 | 10987 | RNAseq | 0.3702 | 0.0616 | |
| SRP133303 | COPS5 | 10987 | RNAseq | 0.2237 | 0.1731 | |
| SRP159526 | COPS5 | 10987 | RNAseq | -0.2218 | 0.4012 | |
| SRP193095 | COPS5 | 10987 | RNAseq | -0.1941 | 0.1311 | |
| SRP219564 | COPS5 | 10987 | RNAseq | -0.0484 | 0.8775 | |
| TCGA | COPS5 | 10987 | RNAseq | 0.1231 | 0.0145 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by COPS5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of COPS5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | COPS5 | 10987 | 15 | 1 | 14 | |
| GSE20123 | COPS5 | 10987 | 16 | 1 | 13 | |
| GSE43470 | COPS5 | 10987 | 15 | 3 | 25 | |
| GSE46452 | COPS5 | 10987 | 20 | 2 | 37 | |
| GSE47630 | COPS5 | 10987 | 23 | 1 | 16 | |
| GSE54993 | COPS5 | 10987 | 1 | 18 | 51 | |
| GSE54994 | COPS5 | 10987 | 30 | 0 | 23 | |
| GSE60625 | COPS5 | 10987 | 0 | 4 | 7 | |
| GSE74703 | COPS5 | 10987 | 13 | 2 | 21 | |
| GSE74704 | COPS5 | 10987 | 11 | 0 | 9 | |
| TCGA | COPS5 | 10987 | 49 | 4 | 43 |
Total number of gains: 193; Total number of losses: 36; Total Number of normals: 259.
Somatic mutations of COPS5:
Generating mutation plots.
Highly correlated genes for COPS5:
Showing top 20/891 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| COPS5 | CBFA2T2 | 0.845979 | 3 | 0 | 3 |
| COPS5 | TMEM237 | 0.810167 | 3 | 0 | 3 |
| COPS5 | RLIM | 0.796641 | 3 | 0 | 3 |
| COPS5 | GIN1 | 0.763344 | 3 | 0 | 3 |
| COPS5 | EIF5B | 0.761458 | 3 | 0 | 3 |
| COPS5 | NDUFA9 | 0.757708 | 3 | 0 | 3 |
| COPS5 | PAIP2 | 0.75477 | 3 | 0 | 3 |
| COPS5 | NAA25 | 0.750704 | 3 | 0 | 3 |
| COPS5 | CARS2 | 0.740543 | 3 | 0 | 3 |
| COPS5 | MRPS28 | 0.73188 | 10 | 0 | 10 |
| COPS5 | FIP1L1 | 0.731667 | 4 | 0 | 3 |
| COPS5 | USP38 | 0.730838 | 3 | 0 | 3 |
| COPS5 | MRPS5 | 0.729479 | 3 | 0 | 3 |
| COPS5 | CETN3 | 0.727609 | 3 | 0 | 3 |
| COPS5 | MTFR1 | 0.725601 | 12 | 0 | 12 |
| COPS5 | IER3IP1 | 0.724401 | 3 | 0 | 3 |
| COPS5 | POLR2K | 0.718104 | 8 | 0 | 8 |
| COPS5 | ALKBH3 | 0.716999 | 3 | 0 | 3 |
| COPS5 | PCNP | 0.714825 | 3 | 0 | 3 |
| COPS5 | NFXL1 | 0.714467 | 4 | 0 | 3 |
For details and further investigation, click here
