| Full name: DOT1 like histone lysine methyltransferase | Alias Symbol: KIAA1814|DOT1|KMT4 | ||
| Type: protein-coding gene | Cytoband: 19p13.3 | ||
| Entrez ID: 84444 | HGNC ID: HGNC:24948 | Ensembl Gene: ENSG00000104885 | OMIM ID: 607375 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of DOT1L:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DOT1L | 84444 | 231297_at | 0.3471 | 0.5097 | |
| GSE20347 | DOT1L | 84444 | 214865_at | -0.0978 | 0.0507 | |
| GSE23400 | DOT1L | 84444 | 214865_at | -0.1910 | 0.0000 | |
| GSE26886 | DOT1L | 84444 | 231297_at | 0.2535 | 0.1291 | |
| GSE29001 | DOT1L | 84444 | 214865_at | -0.1081 | 0.2897 | |
| GSE38129 | DOT1L | 84444 | 214865_at | -0.1216 | 0.0143 | |
| GSE45670 | DOT1L | 84444 | 231297_at | 0.1781 | 0.1547 | |
| GSE53622 | DOT1L | 84444 | 45390 | 0.3854 | 0.0000 | |
| GSE53624 | DOT1L | 84444 | 45390 | 0.3062 | 0.0003 | |
| GSE63941 | DOT1L | 84444 | 231297_at | -0.0324 | 0.9029 | |
| GSE77861 | DOT1L | 84444 | 226201_at | 0.1880 | 0.1513 | |
| GSE97050 | DOT1L | 84444 | A_23_P408768 | 0.4433 | 0.1626 | |
| SRP007169 | DOT1L | 84444 | RNAseq | -0.0620 | 0.8742 | |
| SRP008496 | DOT1L | 84444 | RNAseq | -0.1653 | 0.6252 | |
| SRP064894 | DOT1L | 84444 | RNAseq | -0.2439 | 0.2335 | |
| SRP133303 | DOT1L | 84444 | RNAseq | 0.0077 | 0.9713 | |
| SRP159526 | DOT1L | 84444 | RNAseq | -0.0028 | 0.9913 | |
| SRP193095 | DOT1L | 84444 | RNAseq | 0.0900 | 0.5923 | |
| SRP219564 | DOT1L | 84444 | RNAseq | -0.1623 | 0.6787 | |
| TCGA | DOT1L | 84444 | RNAseq | -0.0428 | 0.3678 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by DOT1L expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DOT1L:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DOT1L | 84444 | 4 | 6 | 20 | |
| GSE20123 | DOT1L | 84444 | 4 | 5 | 21 | |
| GSE43470 | DOT1L | 84444 | 1 | 10 | 32 | |
| GSE46452 | DOT1L | 84444 | 47 | 1 | 11 | |
| GSE47630 | DOT1L | 84444 | 5 | 7 | 28 | |
| GSE54993 | DOT1L | 84444 | 16 | 3 | 51 | |
| GSE54994 | DOT1L | 84444 | 8 | 15 | 30 | |
| GSE60625 | DOT1L | 84444 | 9 | 0 | 2 | |
| GSE74703 | DOT1L | 84444 | 1 | 7 | 28 | |
| GSE74704 | DOT1L | 84444 | 3 | 3 | 14 | |
| TCGA | DOT1L | 84444 | 6 | 25 | 65 |
Total number of gains: 104; Total number of losses: 82; Total Number of normals: 302.
Somatic mutations of DOT1L:
Generating mutation plots.
Highly correlated genes for DOT1L:
Showing top 20/197 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DOT1L | FUCA2 | 0.762685 | 3 | 0 | 3 |
| DOT1L | OR2T12 | 0.758475 | 3 | 0 | 3 |
| DOT1L | THOP1 | 0.741129 | 3 | 0 | 3 |
| DOT1L | GMEB2 | 0.738433 | 3 | 0 | 3 |
| DOT1L | ACBD6 | 0.724375 | 4 | 0 | 4 |
| DOT1L | ALKBH6 | 0.722309 | 4 | 0 | 3 |
| DOT1L | ZBED1 | 0.719175 | 3 | 0 | 3 |
| DOT1L | TP53AIP1 | 0.718605 | 4 | 0 | 4 |
| DOT1L | QPCTL | 0.704186 | 3 | 0 | 3 |
| DOT1L | ZIM2 | 0.70024 | 3 | 0 | 3 |
| DOT1L | LSR | 0.699002 | 3 | 0 | 3 |
| DOT1L | SLC37A3 | 0.698594 | 3 | 0 | 3 |
| DOT1L | CARD10 | 0.696118 | 4 | 0 | 4 |
| DOT1L | JOSD2 | 0.695262 | 4 | 0 | 4 |
| DOT1L | TMEM237 | 0.686897 | 3 | 0 | 3 |
| DOT1L | PDE7A | 0.684822 | 3 | 0 | 3 |
| DOT1L | B4GALT3 | 0.684046 | 3 | 0 | 3 |
| DOT1L | KCTD13 | 0.675461 | 4 | 0 | 3 |
| DOT1L | WDR93 | 0.671494 | 3 | 0 | 3 |
| DOT1L | EMILIN2 | 0.670776 | 3 | 0 | 3 |
For details and further investigation, click here
