| Full name: thimet oligopeptidase 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 19p13.3 | ||
| Entrez ID: 7064 | HGNC ID: HGNC:11793 | Ensembl Gene: | OMIM ID: 601117 |
| Drug and gene relationship at DGIdb | |||
Expression of THOP1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | THOP1 | 7064 | 203235_at | 0.5303 | 0.0439 | |
| GSE20347 | THOP1 | 7064 | 203235_at | 0.2841 | 0.0684 | |
| GSE23400 | THOP1 | 7064 | 203235_at | 0.2515 | 0.0000 | |
| GSE26886 | THOP1 | 7064 | 203235_at | 0.1248 | 0.3928 | |
| GSE29001 | THOP1 | 7064 | 203235_at | 0.1048 | 0.5052 | |
| GSE38129 | THOP1 | 7064 | 203235_at | 0.4495 | 0.0001 | |
| GSE45670 | THOP1 | 7064 | 203235_at | 0.3380 | 0.0031 | |
| GSE53622 | THOP1 | 7064 | 165170 | 0.2098 | 0.0080 | |
| GSE53624 | THOP1 | 7064 | 165170 | 0.5074 | 0.0000 | |
| GSE63941 | THOP1 | 7064 | 203235_at | 0.2179 | 0.5646 | |
| GSE77861 | THOP1 | 7064 | 203235_at | 0.3064 | 0.0281 | |
| GSE97050 | THOP1 | 7064 | A_23_P28057 | 0.1925 | 0.5291 | |
| SRP007169 | THOP1 | 7064 | RNAseq | -0.5045 | 0.2757 | |
| SRP008496 | THOP1 | 7064 | RNAseq | -0.3740 | 0.2024 | |
| SRP064894 | THOP1 | 7064 | RNAseq | 0.4344 | 0.0792 | |
| SRP133303 | THOP1 | 7064 | RNAseq | 0.1570 | 0.4790 | |
| SRP159526 | THOP1 | 7064 | RNAseq | 0.2394 | 0.1998 | |
| SRP193095 | THOP1 | 7064 | RNAseq | 0.2094 | 0.0746 | |
| SRP219564 | THOP1 | 7064 | RNAseq | 0.2668 | 0.4303 | |
| TCGA | THOP1 | 7064 | RNAseq | 0.2907 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by THOP1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of THOP1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | THOP1 | 7064 | 4 | 4 | 22 | |
| GSE20123 | THOP1 | 7064 | 3 | 4 | 23 | |
| GSE43470 | THOP1 | 7064 | 1 | 9 | 33 | |
| GSE46452 | THOP1 | 7064 | 47 | 1 | 11 | |
| GSE47630 | THOP1 | 7064 | 5 | 7 | 28 | |
| GSE54993 | THOP1 | 7064 | 16 | 3 | 51 | |
| GSE54994 | THOP1 | 7064 | 8 | 16 | 29 | |
| GSE60625 | THOP1 | 7064 | 9 | 0 | 2 | |
| GSE74703 | THOP1 | 7064 | 1 | 6 | 29 | |
| GSE74704 | THOP1 | 7064 | 1 | 3 | 16 | |
| TCGA | THOP1 | 7064 | 7 | 23 | 66 |
Total number of gains: 102; Total number of losses: 76; Total Number of normals: 310.
Somatic mutations of THOP1:
Generating mutation plots.
Highly correlated genes for THOP1:
Showing top 20/1295 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| THOP1 | GOLIM4 | 0.785754 | 3 | 0 | 3 |
| THOP1 | CHML | 0.77504 | 3 | 0 | 3 |
| THOP1 | IFNGR1 | 0.766887 | 3 | 0 | 3 |
| THOP1 | TSNAX | 0.761188 | 3 | 0 | 3 |
| THOP1 | ARV1 | 0.754734 | 3 | 0 | 3 |
| THOP1 | CIAO1 | 0.754324 | 4 | 0 | 4 |
| THOP1 | NOL10 | 0.748947 | 5 | 0 | 5 |
| THOP1 | CDCA2 | 0.748148 | 4 | 0 | 4 |
| THOP1 | DOT1L | 0.741129 | 3 | 0 | 3 |
| THOP1 | NAV1 | 0.73283 | 4 | 0 | 4 |
| THOP1 | CDH24 | 0.732086 | 3 | 0 | 3 |
| THOP1 | TTC39C | 0.725184 | 3 | 0 | 3 |
| THOP1 | CCM2 | 0.713436 | 4 | 0 | 4 |
| THOP1 | HDDC3 | 0.711454 | 3 | 0 | 3 |
| THOP1 | ZBTB2 | 0.709761 | 3 | 0 | 3 |
| THOP1 | TGFB1 | 0.70269 | 3 | 0 | 3 |
| THOP1 | EBNA1BP2 | 0.70132 | 3 | 0 | 3 |
| THOP1 | CHUK | 0.697917 | 4 | 0 | 3 |
| THOP1 | YWHAG | 0.695593 | 5 | 0 | 4 |
| THOP1 | ITGB1BP1 | 0.692211 | 3 | 0 | 3 |
For details and further investigation, click here
