| Full name: tumor protein p53 regulated apoptosis inducing protein 1 | Alias Symbol: p53AIP1 | ||
| Type: protein-coding gene | Cytoband: 11q24.3 | ||
| Entrez ID: 63970 | HGNC ID: HGNC:29984 | Ensembl Gene: ENSG00000120471 | OMIM ID: 605426 |
| Drug and gene relationship at DGIdb | |||
TP53AIP1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04115 | p53 signaling pathway | |
| hsa04210 | Apoptosis |
Expression of TP53AIP1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TP53AIP1 | 63970 | 223919_at | 0.4415 | 0.4793 | |
| GSE20347 | TP53AIP1 | 63970 | 220403_s_at | -0.6401 | 0.0447 | |
| GSE23400 | TP53AIP1 | 63970 | 220403_s_at | -0.1838 | 0.2275 | |
| GSE26886 | TP53AIP1 | 63970 | 220403_s_at | -1.3996 | 0.0006 | |
| GSE29001 | TP53AIP1 | 63970 | 220403_s_at | -0.5376 | 0.3863 | |
| GSE38129 | TP53AIP1 | 63970 | 220403_s_at | -0.3962 | 0.2960 | |
| GSE45670 | TP53AIP1 | 63970 | 220403_s_at | -0.2969 | 0.4989 | |
| GSE53622 | TP53AIP1 | 63970 | 48796 | 0.3801 | 0.0008 | |
| GSE53624 | TP53AIP1 | 63970 | 48796 | 0.1237 | 0.4408 | |
| GSE63941 | TP53AIP1 | 63970 | 223920_s_at | 0.4251 | 0.0764 | |
| GSE77861 | TP53AIP1 | 63970 | 220403_s_at | -0.6183 | 0.0411 | |
| GSE97050 | TP53AIP1 | 63970 | A_24_P152398 | 0.1512 | 0.5726 | |
| SRP007169 | TP53AIP1 | 63970 | RNAseq | -1.4858 | 0.0309 | |
| SRP008496 | TP53AIP1 | 63970 | RNAseq | -0.6157 | 0.4105 | |
| SRP064894 | TP53AIP1 | 63970 | RNAseq | -0.6944 | 0.1139 | |
| SRP133303 | TP53AIP1 | 63970 | RNAseq | -1.1220 | 0.0000 | |
| SRP159526 | TP53AIP1 | 63970 | RNAseq | -1.9325 | 0.0044 | |
| SRP219564 | TP53AIP1 | 63970 | RNAseq | -2.7487 | 0.0211 | |
| TCGA | TP53AIP1 | 63970 | RNAseq | 1.5387 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 5.
Survival by TP53AIP1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TP53AIP1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TP53AIP1 | 63970 | 0 | 13 | 17 | |
| GSE20123 | TP53AIP1 | 63970 | 0 | 13 | 17 | |
| GSE43470 | TP53AIP1 | 63970 | 2 | 7 | 34 | |
| GSE46452 | TP53AIP1 | 63970 | 3 | 26 | 30 | |
| GSE47630 | TP53AIP1 | 63970 | 2 | 19 | 19 | |
| GSE54993 | TP53AIP1 | 63970 | 10 | 0 | 60 | |
| GSE54994 | TP53AIP1 | 63970 | 5 | 19 | 29 | |
| GSE60625 | TP53AIP1 | 63970 | 0 | 3 | 8 | |
| GSE74703 | TP53AIP1 | 63970 | 1 | 5 | 30 | |
| GSE74704 | TP53AIP1 | 63970 | 0 | 9 | 11 | |
| TCGA | TP53AIP1 | 63970 | 6 | 50 | 40 |
Total number of gains: 29; Total number of losses: 164; Total Number of normals: 295.
Somatic mutations of TP53AIP1:
Generating mutation plots.
Highly correlated genes for TP53AIP1:
Showing top 20/189 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TP53AIP1 | CALY | 0.795316 | 3 | 0 | 3 |
| TP53AIP1 | DEFB132 | 0.794103 | 3 | 0 | 3 |
| TP53AIP1 | HSPA4 | 0.788534 | 3 | 0 | 3 |
| TP53AIP1 | OR2T33 | 0.783344 | 3 | 0 | 3 |
| TP53AIP1 | OR2AT4 | 0.780847 | 3 | 0 | 3 |
| TP53AIP1 | KIR3DL2 | 0.778678 | 3 | 0 | 3 |
| TP53AIP1 | ZBTB37 | 0.776007 | 3 | 0 | 3 |
| TP53AIP1 | KIAA2026 | 0.771765 | 3 | 0 | 3 |
| TP53AIP1 | KRTAP10-4 | 0.768904 | 3 | 0 | 3 |
| TP53AIP1 | FIBCD1 | 0.768694 | 3 | 0 | 3 |
| TP53AIP1 | OR2T12 | 0.765855 | 3 | 0 | 3 |
| TP53AIP1 | ARHGEF33 | 0.762036 | 3 | 0 | 3 |
| TP53AIP1 | SLC26A5 | 0.759746 | 3 | 0 | 3 |
| TP53AIP1 | KRTAP12-2 | 0.756186 | 3 | 0 | 3 |
| TP53AIP1 | FOXP4 | 0.74958 | 3 | 0 | 3 |
| TP53AIP1 | NQO2 | 0.744222 | 3 | 0 | 3 |
| TP53AIP1 | DENND1B | 0.744193 | 3 | 0 | 3 |
| TP53AIP1 | SFTPA2 | 0.741361 | 3 | 0 | 3 |
| TP53AIP1 | MLKL | 0.740288 | 3 | 0 | 3 |
| TP53AIP1 | ZNF546 | 0.736111 | 3 | 0 | 3 |
For details and further investigation, click here
