ERBB2

 

Full name: erb-b2 receptor tyrosine kinase 2 Alias Symbol: NEU|HER-2|CD340|HER2
Type: protein-coding gene Cytoband: 17q12
Entrez ID: 2064 HGNC ID: HGNC:3430 Ensembl Gene: ENSG00000141736 OMIM ID: 164870
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 20/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

ERBB2 involved pathways:

KEGG pathway Description View
hsa04012ErbB signaling pathway
hsa04020Calcium signaling pathway
hsa04066HIF-1 signaling pathway
hsa04510Focal adhesion
hsa04520Adherens junction
hsa05200Pathways in cancer
hsa05205Proteoglycans in cancer
hsa05212Pancreatic cancer
hsa05215Prostate cancer
hsa05219Bladder cancer
hsa05223Non-small cell lung cancer

 

Expression of ERBB2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ERBB2 2064 216836_s_at -0.3227 0.6756
GSE20347 ERBB2 2064 216836_s_at -1.0380 0.0000
GSE23400 ERBB2 2064 216836_s_at -0.7465 0.0000
GSE26886 ERBB2 2064 216836_s_at -1.4156 0.0000
GSE29001 ERBB2 2064 216836_s_at -0.9949 0.0012
GSE38129 ERBB2 2064 216836_s_at -0.7447 0.0002
GSE45670 ERBB2 2064 216836_s_at -0.2039 0.4289
GSE53622 ERBB2 2064 122031 -0.8218 0.0000
GSE53624 ERBB2 2064 122031 -1.2700 0.0000
GSE63941 ERBB2 2064 216836_s_at 0.5330 0.6558
GSE77861 ERBB2 2064 216836_s_at -0.5871 0.0472
GSE97050 ERBB2 2064 A_23_P89249 -0.2311 0.3758
SRP007169 ERBB2 2064 RNAseq -1.1425 0.0649
SRP008496 ERBB2 2064 RNAseq -1.9069 0.0000
SRP064894 ERBB2 2064 RNAseq -0.9416 0.0000
SRP133303 ERBB2 2064 RNAseq -1.4782 0.0000
SRP159526 ERBB2 2064 RNAseq -1.4151 0.0000
SRP193095 ERBB2 2064 RNAseq -1.3061 0.0000
SRP219564 ERBB2 2064 RNAseq -1.4694 0.0018
TCGA ERBB2 2064 RNAseq -0.0949 0.2075

Upregulated datasets: 0; Downregulated datasets: 8.  

 

Survival by ERBB2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ERBB2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ERBB2 2064 9 1 20
GSE20123 ERBB2 2064 9 1 20
GSE43470 ERBB2 2064 1 1 41
GSE46452 ERBB2 2064 34 0 25
GSE47630 ERBB2 2064 8 1 31
GSE54993 ERBB2 2064 3 4 63
GSE54994 ERBB2 2064 9 5 39
GSE60625 ERBB2 2064 4 0 7
GSE74703 ERBB2 2064 1 0 35
GSE74704 ERBB2 2064 5 1 14
TCGA ERBB2 2064 23 8 65

Total number of gains: 106; Total number of losses: 22; Total Number of normals: 360.  

 

Somatic mutations of ERBB2:

 

Generating mutation plots.

 

Highly correlated genes for ERBB2:

 

Showing top 20/867 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ERBB2MFSD2B0.818252303
ERBB2FAM163B0.814265303
ERBB2PGAP30.80373613013
ERBB2TEN10.796585303
ERBB2OR2Z10.788002303
ERBB2OR10G80.784447303
ERBB2MUC220.783735303
ERBB2NCCRP10.782904303
ERBB2EPS8L20.78276711011
ERBB2KRTAP20-10.78164303
ERBB2VSIG10L0.770864606
ERBB2TPRN0.765902606
ERBB2ZSWIM30.752846303
ERBB2C5orf66-AS10.751519606
ERBB2SYTL10.750565606
ERBB2EPHA10.74961611011
ERBB2RIPK40.743717909
ERBB2NANOS20.742802505
ERBB2SHROOM40.737749303
ERBB2SLC37A10.73680212012

For details and further investigation, click here