| Full name: EPH receptor A1 | Alias Symbol: EPH | ||
| Type: protein-coding gene | Cytoband: 7q34-q35 | ||
| Entrez ID: 2041 | HGNC ID: HGNC:3385 | Ensembl Gene: ENSG00000146904 | OMIM ID: 179610 |
| Drug and gene relationship at DGIdb | |||
EPHA1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04360 | Axon guidance |
Expression of EPHA1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EPHA1 | 2041 | 205977_s_at | -0.9623 | 0.3402 | |
| GSE20347 | EPHA1 | 2041 | 205977_s_at | -1.4753 | 0.0000 | |
| GSE23400 | EPHA1 | 2041 | 205977_s_at | -1.0253 | 0.0000 | |
| GSE26886 | EPHA1 | 2041 | 205977_s_at | -1.8923 | 0.0000 | |
| GSE29001 | EPHA1 | 2041 | 205977_s_at | -1.4295 | 0.0005 | |
| GSE38129 | EPHA1 | 2041 | 205977_s_at | -0.8658 | 0.0167 | |
| GSE45670 | EPHA1 | 2041 | 205977_s_at | -0.3855 | 0.1976 | |
| GSE53622 | EPHA1 | 2041 | 148887 | -1.1373 | 0.0000 | |
| GSE53624 | EPHA1 | 2041 | 148887 | -1.6135 | 0.0000 | |
| GSE63941 | EPHA1 | 2041 | 205977_s_at | 1.8586 | 0.0007 | |
| GSE77861 | EPHA1 | 2041 | 205977_s_at | -0.7921 | 0.0138 | |
| GSE97050 | EPHA1 | 2041 | A_23_P157333 | 0.3408 | 0.6699 | |
| SRP007169 | EPHA1 | 2041 | RNAseq | -0.8209 | 0.0938 | |
| SRP008496 | EPHA1 | 2041 | RNAseq | -1.1038 | 0.0029 | |
| SRP064894 | EPHA1 | 2041 | RNAseq | -1.6930 | 0.0000 | |
| SRP133303 | EPHA1 | 2041 | RNAseq | -1.6848 | 0.0000 | |
| SRP159526 | EPHA1 | 2041 | RNAseq | -2.1287 | 0.0000 | |
| SRP193095 | EPHA1 | 2041 | RNAseq | -1.7471 | 0.0000 | |
| SRP219564 | EPHA1 | 2041 | RNAseq | -2.4679 | 0.0217 | |
| TCGA | EPHA1 | 2041 | RNAseq | 0.3498 | 0.0362 |
Upregulated datasets: 1; Downregulated datasets: 12.
Survival by EPHA1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EPHA1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EPHA1 | 2041 | 4 | 2 | 24 | |
| GSE20123 | EPHA1 | 2041 | 4 | 2 | 24 | |
| GSE43470 | EPHA1 | 2041 | 3 | 4 | 36 | |
| GSE46452 | EPHA1 | 2041 | 7 | 2 | 50 | |
| GSE47630 | EPHA1 | 2041 | 6 | 7 | 27 | |
| GSE54993 | EPHA1 | 2041 | 3 | 4 | 63 | |
| GSE54994 | EPHA1 | 2041 | 5 | 8 | 40 | |
| GSE60625 | EPHA1 | 2041 | 0 | 0 | 11 | |
| GSE74703 | EPHA1 | 2041 | 2 | 4 | 30 | |
| GSE74704 | EPHA1 | 2041 | 2 | 2 | 16 | |
| TCGA | EPHA1 | 2041 | 28 | 25 | 43 |
Total number of gains: 64; Total number of losses: 60; Total Number of normals: 364.
Somatic mutations of EPHA1:
Generating mutation plots.
Highly correlated genes for EPHA1:
Showing top 20/1137 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EPHA1 | TECR | 0.842017 | 11 | 0 | 11 |
| EPHA1 | EVPL | 0.840084 | 13 | 0 | 12 |
| EPHA1 | EPS8L2 | 0.8324 | 11 | 0 | 11 |
| EPHA1 | MPZL3 | 0.825719 | 7 | 0 | 7 |
| EPHA1 | RAB25 | 0.824588 | 12 | 0 | 12 |
| EPHA1 | PLD1 | 0.824435 | 10 | 0 | 10 |
| EPHA1 | CYSRT1 | 0.822576 | 6 | 0 | 6 |
| EPHA1 | ZDHHC13 | 0.814148 | 11 | 0 | 11 |
| EPHA1 | RAET1E | 0.811912 | 7 | 0 | 7 |
| EPHA1 | CXCR2 | 0.807291 | 10 | 0 | 10 |
| EPHA1 | SCNN1B | 0.805865 | 11 | 0 | 11 |
| EPHA1 | GRHL3 | 0.804406 | 9 | 0 | 9 |
| EPHA1 | C6orf132 | 0.801115 | 8 | 0 | 8 |
| EPHA1 | PPL | 0.800242 | 13 | 0 | 13 |
| EPHA1 | NEBL | 0.800182 | 12 | 0 | 12 |
| EPHA1 | SNX24 | 0.799555 | 11 | 0 | 11 |
| EPHA1 | EPN3 | 0.79416 | 10 | 0 | 10 |
| EPHA1 | ARHGAP40 | 0.792714 | 3 | 0 | 3 |
| EPHA1 | CWH43 | 0.792268 | 9 | 0 | 9 |
| EPHA1 | TTC22 | 0.790995 | 12 | 0 | 12 |
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