| Full name: receptor interacting serine/threonine kinase 4 | Alias Symbol: DIK|ANKK2|RIP4|PKK | ||
| Type: protein-coding gene | Cytoband: 21q22.3 | ||
| Entrez ID: 54101 | HGNC ID: HGNC:496 | Ensembl Gene: ENSG00000183421 | OMIM ID: 605706 |
| Drug and gene relationship at DGIdb | |||
Expression of RIPK4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RIPK4 | 54101 | 221215_s_at | -0.9079 | 0.2643 | |
| GSE20347 | RIPK4 | 54101 | 221215_s_at | -1.6043 | 0.0000 | |
| GSE23400 | RIPK4 | 54101 | 221215_s_at | -0.9718 | 0.0000 | |
| GSE26886 | RIPK4 | 54101 | 221215_s_at | -1.9881 | 0.0000 | |
| GSE29001 | RIPK4 | 54101 | 221215_s_at | -1.3284 | 0.0000 | |
| GSE38129 | RIPK4 | 54101 | 221215_s_at | -0.6578 | 0.1201 | |
| GSE45670 | RIPK4 | 54101 | 221215_s_at | -0.2051 | 0.5661 | |
| GSE63941 | RIPK4 | 54101 | 221215_s_at | 3.6645 | 0.0005 | |
| GSE77861 | RIPK4 | 54101 | 221215_s_at | -1.1494 | 0.0077 | |
| GSE97050 | RIPK4 | 54101 | A_33_P3400728 | 0.0196 | 0.9381 | |
| SRP007169 | RIPK4 | 54101 | RNAseq | -2.3425 | 0.0000 | |
| SRP008496 | RIPK4 | 54101 | RNAseq | -2.2978 | 0.0000 | |
| SRP064894 | RIPK4 | 54101 | RNAseq | -1.9917 | 0.0000 | |
| SRP133303 | RIPK4 | 54101 | RNAseq | -1.2962 | 0.0001 | |
| SRP159526 | RIPK4 | 54101 | RNAseq | -1.4001 | 0.0029 | |
| SRP193095 | RIPK4 | 54101 | RNAseq | -1.2579 | 0.0000 | |
| SRP219564 | RIPK4 | 54101 | RNAseq | -1.9972 | 0.0473 | |
| TCGA | RIPK4 | 54101 | RNAseq | 0.1179 | 0.3141 |
Upregulated datasets: 1; Downregulated datasets: 11.
Survival by RIPK4 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of RIPK4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RIPK4 | 54101 | 2 | 8 | 20 | |
| GSE20123 | RIPK4 | 54101 | 2 | 8 | 20 | |
| GSE43470 | RIPK4 | 54101 | 0 | 13 | 30 | |
| GSE46452 | RIPK4 | 54101 | 1 | 21 | 37 | |
| GSE47630 | RIPK4 | 54101 | 6 | 17 | 17 | |
| GSE54993 | RIPK4 | 54101 | 8 | 1 | 61 | |
| GSE54994 | RIPK4 | 54101 | 3 | 8 | 42 | |
| GSE60625 | RIPK4 | 54101 | 0 | 0 | 11 | |
| GSE74703 | RIPK4 | 54101 | 0 | 10 | 26 | |
| GSE74704 | RIPK4 | 54101 | 1 | 4 | 15 | |
| TCGA | RIPK4 | 54101 | 7 | 41 | 48 |
Total number of gains: 30; Total number of losses: 131; Total Number of normals: 327.
Somatic mutations of RIPK4:
Generating mutation plots.
Highly correlated genes for RIPK4:
Showing top 20/693 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RIPK4 | EPS8L2 | 0.827094 | 9 | 0 | 9 |
| RIPK4 | BRAF | 0.784675 | 3 | 0 | 3 |
| RIPK4 | CLDN7 | 0.782682 | 9 | 0 | 9 |
| RIPK4 | FUT3 | 0.778118 | 9 | 0 | 8 |
| RIPK4 | FUT6 | 0.772625 | 9 | 0 | 8 |
| RIPK4 | CBLN4 | 0.767011 | 3 | 0 | 3 |
| RIPK4 | DUOX1 | 0.762728 | 10 | 0 | 8 |
| RIPK4 | RAB27B | 0.762319 | 8 | 0 | 8 |
| RIPK4 | CARD6 | 0.759065 | 4 | 0 | 4 |
| RIPK4 | TACSTD2 | 0.758121 | 10 | 0 | 10 |
| RIPK4 | EPHX3 | 0.753203 | 8 | 0 | 8 |
| RIPK4 | ARHGAP32 | 0.753157 | 8 | 0 | 8 |
| RIPK4 | SYTL1 | 0.75159 | 5 | 0 | 5 |
| RIPK4 | PITX1 | 0.751555 | 9 | 0 | 8 |
| RIPK4 | C16orf82 | 0.749892 | 3 | 0 | 3 |
| RIPK4 | EXPH5 | 0.747505 | 8 | 0 | 8 |
| RIPK4 | RBM47 | 0.747313 | 9 | 0 | 8 |
| RIPK4 | RIOK3 | 0.74583 | 8 | 0 | 8 |
| RIPK4 | PPL | 0.745578 | 10 | 0 | 9 |
| RIPK4 | MYO5B | 0.744484 | 6 | 0 | 6 |
For details and further investigation, click here
