| Full name: exocyst complex component 4 | Alias Symbol: KIAA1699|MGC27170|SEC8|Sec8p | ||
| Type: protein-coding gene | Cytoband: 7q33 | ||
| Entrez ID: 60412 | HGNC ID: HGNC:30389 | Ensembl Gene: ENSG00000131558 | OMIM ID: 608185 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of EXOC4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EXOC4 | 60412 | 224926_at | -0.1271 | 0.8487 | |
| GSE26886 | EXOC4 | 60412 | 224926_at | -0.4767 | 0.0068 | |
| GSE45670 | EXOC4 | 60412 | 224926_at | -0.2575 | 0.2308 | |
| GSE53622 | EXOC4 | 60412 | 146940 | -0.2865 | 0.0000 | |
| GSE53624 | EXOC4 | 60412 | 146940 | -0.2260 | 0.0014 | |
| GSE63941 | EXOC4 | 60412 | 224926_at | -1.2105 | 0.0422 | |
| GSE77861 | EXOC4 | 60412 | 224926_at | -0.1319 | 0.4208 | |
| GSE97050 | EXOC4 | 60412 | A_24_P7946 | 0.0210 | 0.9341 | |
| SRP007169 | EXOC4 | 60412 | RNAseq | -0.0756 | 0.8169 | |
| SRP008496 | EXOC4 | 60412 | RNAseq | -0.0252 | 0.9004 | |
| SRP064894 | EXOC4 | 60412 | RNAseq | -0.1140 | 0.3466 | |
| SRP133303 | EXOC4 | 60412 | RNAseq | -0.0336 | 0.7959 | |
| SRP159526 | EXOC4 | 60412 | RNAseq | -0.3008 | 0.2235 | |
| SRP193095 | EXOC4 | 60412 | RNAseq | -0.1114 | 0.3288 | |
| SRP219564 | EXOC4 | 60412 | RNAseq | -0.4581 | 0.0463 | |
| TCGA | EXOC4 | 60412 | RNAseq | -0.0370 | 0.4281 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by EXOC4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EXOC4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EXOC4 | 60412 | 5 | 2 | 23 | |
| GSE20123 | EXOC4 | 60412 | 5 | 2 | 23 | |
| GSE43470 | EXOC4 | 60412 | 2 | 3 | 38 | |
| GSE46452 | EXOC4 | 60412 | 7 | 2 | 50 | |
| GSE47630 | EXOC4 | 60412 | 7 | 4 | 29 | |
| GSE54993 | EXOC4 | 60412 | 3 | 5 | 62 | |
| GSE54994 | EXOC4 | 60412 | 6 | 8 | 39 | |
| GSE60625 | EXOC4 | 60412 | 0 | 0 | 11 | |
| GSE74703 | EXOC4 | 60412 | 2 | 3 | 31 | |
| GSE74704 | EXOC4 | 60412 | 1 | 2 | 17 | |
| TCGA | EXOC4 | 60412 | 28 | 28 | 40 |
Total number of gains: 66; Total number of losses: 59; Total Number of normals: 363.
Somatic mutations of EXOC4:
Generating mutation plots.
Highly correlated genes for EXOC4:
Showing top 20/314 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EXOC4 | MUL1 | 0.831652 | 3 | 0 | 3 |
| EXOC4 | IFT46 | 0.830506 | 3 | 0 | 3 |
| EXOC4 | C21orf91 | 0.813888 | 3 | 0 | 3 |
| EXOC4 | SLC37A3 | 0.794282 | 3 | 0 | 3 |
| EXOC4 | HSD17B10 | 0.777684 | 3 | 0 | 3 |
| EXOC4 | MSL3 | 0.770029 | 3 | 0 | 3 |
| EXOC4 | PUS7L | 0.76935 | 3 | 0 | 3 |
| EXOC4 | ARIH1 | 0.768157 | 3 | 0 | 3 |
| EXOC4 | FUCA1 | 0.768011 | 3 | 0 | 3 |
| EXOC4 | SPATA5L1 | 0.756653 | 3 | 0 | 3 |
| EXOC4 | DPY19L3 | 0.750333 | 3 | 0 | 3 |
| EXOC4 | TRAPPC2 | 0.746004 | 3 | 0 | 3 |
| EXOC4 | HECTD3 | 0.744733 | 3 | 0 | 3 |
| EXOC4 | CTPS2 | 0.742924 | 3 | 0 | 3 |
| EXOC4 | TRIM23 | 0.740455 | 3 | 0 | 3 |
| EXOC4 | DNAJB14 | 0.738313 | 3 | 0 | 3 |
| EXOC4 | CTTNBP2NL | 0.738012 | 4 | 0 | 4 |
| EXOC4 | TNKS2 | 0.736316 | 3 | 0 | 3 |
| EXOC4 | TRAPPC8 | 0.732878 | 3 | 0 | 3 |
| EXOC4 | RBM7 | 0.732433 | 3 | 0 | 3 |
For details and further investigation, click here
