| Full name: HECT domain E3 ubiquitin protein ligase 3 | Alias Symbol: FLJ21156 | ||
| Type: protein-coding gene | Cytoband: 1p34.1 | ||
| Entrez ID: 79654 | HGNC ID: HGNC:26117 | Ensembl Gene: ENSG00000126107 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of HECTD3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HECTD3 | 79654 | 218632_at | -0.0910 | 0.9055 | |
| GSE20347 | HECTD3 | 79654 | 218632_at | -0.7482 | 0.0000 | |
| GSE23400 | HECTD3 | 79654 | 218632_at | -0.1369 | 0.0137 | |
| GSE26886 | HECTD3 | 79654 | 218632_at | -0.4088 | 0.0633 | |
| GSE29001 | HECTD3 | 79654 | 218632_at | -0.4495 | 0.3856 | |
| GSE38129 | HECTD3 | 79654 | 218632_at | -0.5808 | 0.0000 | |
| GSE45670 | HECTD3 | 79654 | 218632_at | -0.0463 | 0.7931 | |
| GSE53622 | HECTD3 | 79654 | 159229 | -0.2982 | 0.0004 | |
| GSE53624 | HECTD3 | 79654 | 159229 | -0.2393 | 0.0027 | |
| GSE63941 | HECTD3 | 79654 | 218632_at | 0.4708 | 0.4259 | |
| GSE77861 | HECTD3 | 79654 | 218632_at | -0.4008 | 0.2549 | |
| GSE97050 | HECTD3 | 79654 | A_23_P149221 | -0.0559 | 0.8678 | |
| SRP007169 | HECTD3 | 79654 | RNAseq | -1.1528 | 0.0052 | |
| SRP008496 | HECTD3 | 79654 | RNAseq | -1.2059 | 0.0000 | |
| SRP064894 | HECTD3 | 79654 | RNAseq | 0.2180 | 0.0942 | |
| SRP133303 | HECTD3 | 79654 | RNAseq | -0.2823 | 0.1384 | |
| SRP159526 | HECTD3 | 79654 | RNAseq | -0.5140 | 0.0525 | |
| SRP193095 | HECTD3 | 79654 | RNAseq | -0.3461 | 0.0415 | |
| SRP219564 | HECTD3 | 79654 | RNAseq | 0.2501 | 0.5047 | |
| TCGA | HECTD3 | 79654 | RNAseq | -0.1017 | 0.0367 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by HECTD3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HECTD3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HECTD3 | 79654 | 4 | 3 | 23 | |
| GSE20123 | HECTD3 | 79654 | 4 | 2 | 24 | |
| GSE43470 | HECTD3 | 79654 | 7 | 2 | 34 | |
| GSE46452 | HECTD3 | 79654 | 2 | 1 | 56 | |
| GSE47630 | HECTD3 | 79654 | 9 | 3 | 28 | |
| GSE54993 | HECTD3 | 79654 | 0 | 1 | 69 | |
| GSE54994 | HECTD3 | 79654 | 13 | 2 | 38 | |
| GSE60625 | HECTD3 | 79654 | 0 | 0 | 11 | |
| GSE74703 | HECTD3 | 79654 | 6 | 1 | 29 | |
| GSE74704 | HECTD3 | 79654 | 2 | 0 | 18 | |
| TCGA | HECTD3 | 79654 | 12 | 16 | 68 |
Total number of gains: 59; Total number of losses: 31; Total Number of normals: 398.
Somatic mutations of HECTD3:
Generating mutation plots.
Highly correlated genes for HECTD3:
Showing top 20/803 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HECTD3 | ZNF287 | 0.785127 | 3 | 0 | 3 |
| HECTD3 | CASKIN2 | 0.783534 | 3 | 0 | 3 |
| HECTD3 | C2orf76 | 0.760859 | 3 | 0 | 3 |
| HECTD3 | SLC16A2 | 0.745376 | 3 | 0 | 3 |
| HECTD3 | EXOC4 | 0.744733 | 3 | 0 | 3 |
| HECTD3 | COG1 | 0.741442 | 3 | 0 | 3 |
| HECTD3 | ZNF879 | 0.734321 | 3 | 0 | 3 |
| HECTD3 | CHCHD1 | 0.733827 | 4 | 0 | 4 |
| HECTD3 | RHBDD1 | 0.731619 | 3 | 0 | 3 |
| HECTD3 | PRPS1L1 | 0.725875 | 3 | 0 | 3 |
| HECTD3 | OXNAD1 | 0.724315 | 3 | 0 | 3 |
| HECTD3 | LRRC47 | 0.723622 | 4 | 0 | 4 |
| HECTD3 | ELOF1 | 0.722542 | 4 | 0 | 3 |
| HECTD3 | APBB1IP | 0.722276 | 3 | 0 | 3 |
| HECTD3 | MTERF4 | 0.712647 | 3 | 0 | 3 |
| HECTD3 | VCP | 0.710975 | 3 | 0 | 3 |
| HECTD3 | CSNK1D | 0.710916 | 3 | 0 | 3 |
| HECTD3 | HIC2 | 0.710002 | 4 | 0 | 3 |
| HECTD3 | POLR2E | 0.707255 | 3 | 0 | 3 |
| HECTD3 | ARIH2 | 0.700153 | 3 | 0 | 3 |
For details and further investigation, click here
