| Full name: mitochondrial E3 ubiquitin protein ligase 1 | Alias Symbol: FLJ12875|MULAN|RNF218|MAPL|GIDE | ||
| Type: protein-coding gene | Cytoband: 1p36.12 | ||
| Entrez ID: 79594 | HGNC ID: HGNC:25762 | Ensembl Gene: ENSG00000090432 | OMIM ID: 612037 |
| Drug and gene relationship at DGIdb | |||
Expression of MUL1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MUL1 | 79594 | 218246_at | 0.0081 | 0.9875 | |
| GSE20347 | MUL1 | 79594 | 218246_at | -0.1321 | 0.0934 | |
| GSE23400 | MUL1 | 79594 | 218246_at | -0.0882 | 0.0178 | |
| GSE26886 | MUL1 | 79594 | 218246_at | -0.3973 | 0.0114 | |
| GSE29001 | MUL1 | 79594 | 218246_at | -0.2290 | 0.1591 | |
| GSE38129 | MUL1 | 79594 | 218246_at | -0.2127 | 0.0013 | |
| GSE45670 | MUL1 | 79594 | 218246_at | 0.1093 | 0.4445 | |
| GSE63941 | MUL1 | 79594 | 218246_at | 0.4400 | 0.0922 | |
| GSE77861 | MUL1 | 79594 | 218246_at | -0.1066 | 0.3367 | |
| GSE97050 | MUL1 | 79594 | A_23_P200598 | 0.1602 | 0.4210 | |
| SRP007169 | MUL1 | 79594 | RNAseq | -1.4272 | 0.0002 | |
| SRP008496 | MUL1 | 79594 | RNAseq | -1.3100 | 0.0000 | |
| SRP064894 | MUL1 | 79594 | RNAseq | -0.1502 | 0.4568 | |
| SRP133303 | MUL1 | 79594 | RNAseq | 0.0922 | 0.6513 | |
| SRP159526 | MUL1 | 79594 | RNAseq | -0.2202 | 0.2752 | |
| SRP193095 | MUL1 | 79594 | RNAseq | -0.1645 | 0.1129 | |
| SRP219564 | MUL1 | 79594 | RNAseq | -0.4651 | 0.1273 | |
| TCGA | MUL1 | 79594 | RNAseq | -0.1185 | 0.0201 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by MUL1 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of MUL1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MUL1 | 79594 | 0 | 5 | 25 | |
| GSE20123 | MUL1 | 79594 | 0 | 4 | 26 | |
| GSE43470 | MUL1 | 79594 | 0 | 8 | 35 | |
| GSE46452 | MUL1 | 79594 | 5 | 1 | 53 | |
| GSE47630 | MUL1 | 79594 | 8 | 3 | 29 | |
| GSE54993 | MUL1 | 79594 | 3 | 1 | 66 | |
| GSE54994 | MUL1 | 79594 | 11 | 4 | 38 | |
| GSE60625 | MUL1 | 79594 | 0 | 0 | 11 | |
| GSE74703 | MUL1 | 79594 | 0 | 5 | 31 | |
| GSE74704 | MUL1 | 79594 | 0 | 0 | 20 | |
| TCGA | MUL1 | 79594 | 10 | 22 | 64 |
Total number of gains: 37; Total number of losses: 53; Total Number of normals: 398.
Somatic mutations of MUL1:
Generating mutation plots.
Highly correlated genes for MUL1:
Showing top 20/341 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MUL1 | EXOC4 | 0.831652 | 3 | 0 | 3 |
| MUL1 | PRPF38A | 0.817586 | 3 | 0 | 3 |
| MUL1 | B9D2 | 0.771652 | 4 | 0 | 4 |
| MUL1 | TBC1D22A | 0.744886 | 3 | 0 | 3 |
| MUL1 | UBL5 | 0.743234 | 3 | 0 | 3 |
| MUL1 | SLC25A10 | 0.736258 | 4 | 0 | 4 |
| MUL1 | STOML2 | 0.730206 | 3 | 0 | 3 |
| MUL1 | FLYWCH2 | 0.728798 | 4 | 0 | 4 |
| MUL1 | LSP1 | 0.724822 | 3 | 0 | 3 |
| MUL1 | ARPC4 | 0.723467 | 4 | 0 | 4 |
| MUL1 | GPR132 | 0.720986 | 3 | 0 | 3 |
| MUL1 | RARA | 0.716152 | 3 | 0 | 3 |
| MUL1 | ZBTB22 | 0.708359 | 3 | 0 | 3 |
| MUL1 | ATN1 | 0.706002 | 3 | 0 | 3 |
| MUL1 | LZIC | 0.704455 | 3 | 0 | 3 |
| MUL1 | ERCC2 | 0.698948 | 3 | 0 | 3 |
| MUL1 | GLUD2 | 0.697612 | 3 | 0 | 3 |
| MUL1 | FCRLA | 0.696819 | 3 | 0 | 3 |
| MUL1 | PHACTR1 | 0.696151 | 3 | 0 | 3 |
| MUL1 | ZNF771 | 0.69541 | 3 | 0 | 3 |
For details and further investigation, click here
