| Full name: tankyrase 2 | Alias Symbol: TNKL|TANK2|PARP-5b|PARP-5c|PARP5B|PARP5C|pART6 | ||
| Type: protein-coding gene | Cytoband: 10q23.32 | ||
| Entrez ID: 80351 | HGNC ID: HGNC:15677 | Ensembl Gene: ENSG00000107854 | OMIM ID: 607128 |
| Drug and gene relationship at DGIdb | |||
Expression of TNKS2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TNKS2 | 80351 | 218228_s_at | -0.0187 | 0.9749 | |
| GSE20347 | TNKS2 | 80351 | 218228_s_at | -0.8015 | 0.0000 | |
| GSE23400 | TNKS2 | 80351 | 218228_s_at | -0.2893 | 0.0000 | |
| GSE26886 | TNKS2 | 80351 | 218228_s_at | -1.6967 | 0.0000 | |
| GSE29001 | TNKS2 | 80351 | 218228_s_at | -0.4764 | 0.0442 | |
| GSE38129 | TNKS2 | 80351 | 218228_s_at | -0.5151 | 0.0019 | |
| GSE45670 | TNKS2 | 80351 | 218228_s_at | -0.1646 | 0.1828 | |
| GSE53622 | TNKS2 | 80351 | 74921 | -0.5656 | 0.0000 | |
| GSE53624 | TNKS2 | 80351 | 74921 | -0.3130 | 0.0000 | |
| GSE63941 | TNKS2 | 80351 | 218228_s_at | 0.0043 | 0.9933 | |
| GSE77861 | TNKS2 | 80351 | 218228_s_at | -0.3274 | 0.1036 | |
| GSE97050 | TNKS2 | 80351 | A_23_P12620 | -0.1162 | 0.7755 | |
| SRP007169 | TNKS2 | 80351 | RNAseq | -1.1385 | 0.0016 | |
| SRP008496 | TNKS2 | 80351 | RNAseq | -0.8883 | 0.0000 | |
| SRP064894 | TNKS2 | 80351 | RNAseq | -0.7806 | 0.0135 | |
| SRP133303 | TNKS2 | 80351 | RNAseq | -0.2620 | 0.0093 | |
| SRP159526 | TNKS2 | 80351 | RNAseq | -0.6617 | 0.0500 | |
| SRP193095 | TNKS2 | 80351 | RNAseq | -0.5685 | 0.0000 | |
| SRP219564 | TNKS2 | 80351 | RNAseq | -0.7600 | 0.0366 | |
| TCGA | TNKS2 | 80351 | RNAseq | -0.0707 | 0.1062 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by TNKS2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TNKS2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TNKS2 | 80351 | 1 | 7 | 22 | |
| GSE20123 | TNKS2 | 80351 | 1 | 6 | 23 | |
| GSE43470 | TNKS2 | 80351 | 0 | 8 | 35 | |
| GSE46452 | TNKS2 | 80351 | 0 | 11 | 48 | |
| GSE47630 | TNKS2 | 80351 | 2 | 14 | 24 | |
| GSE54993 | TNKS2 | 80351 | 7 | 0 | 63 | |
| GSE54994 | TNKS2 | 80351 | 1 | 10 | 42 | |
| GSE60625 | TNKS2 | 80351 | 0 | 0 | 11 | |
| GSE74703 | TNKS2 | 80351 | 0 | 6 | 30 | |
| GSE74704 | TNKS2 | 80351 | 0 | 4 | 16 | |
| TCGA | TNKS2 | 80351 | 7 | 27 | 62 |
Total number of gains: 19; Total number of losses: 93; Total Number of normals: 376.
Somatic mutations of TNKS2:
Generating mutation plots.
Highly correlated genes for TNKS2:
Showing top 20/1266 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TNKS2 | GGA3 | 0.787315 | 3 | 0 | 3 |
| TNKS2 | WDR77 | 0.77573 | 3 | 0 | 3 |
| TNKS2 | COPE | 0.773421 | 4 | 0 | 4 |
| TNKS2 | SOX21-AS1 | 0.756431 | 3 | 0 | 3 |
| TNKS2 | CCNYL1 | 0.753832 | 4 | 0 | 4 |
| TNKS2 | TMEM117 | 0.75248 | 3 | 0 | 3 |
| TNKS2 | GTF2A1 | 0.747694 | 4 | 0 | 3 |
| TNKS2 | DDX52 | 0.743814 | 3 | 0 | 3 |
| TNKS2 | EXOC4 | 0.736316 | 3 | 0 | 3 |
| TNKS2 | PRPF38A | 0.735546 | 4 | 0 | 4 |
| TNKS2 | PSMD8 | 0.732635 | 3 | 0 | 3 |
| TNKS2 | EPM2AIP1 | 0.731696 | 3 | 0 | 3 |
| TNKS2 | MRPL27 | 0.730374 | 3 | 0 | 3 |
| TNKS2 | C5orf51 | 0.721406 | 3 | 0 | 3 |
| TNKS2 | UBE4B | 0.717105 | 3 | 0 | 3 |
| TNKS2 | AP1M2 | 0.71476 | 5 | 0 | 5 |
| TNKS2 | ZMAT2 | 0.71363 | 3 | 0 | 3 |
| TNKS2 | TYSND1 | 0.712525 | 4 | 0 | 4 |
| TNKS2 | ERI2 | 0.712477 | 3 | 0 | 3 |
| TNKS2 | LARP4 | 0.708286 | 4 | 0 | 3 |
For details and further investigation, click here
