| Full name: F-box protein 25 | Alias Symbol: FBX25 | ||
| Type: protein-coding gene | Cytoband: 8p23.3 | ||
| Entrez ID: 26260 | HGNC ID: HGNC:13596 | Ensembl Gene: ENSG00000147364 | OMIM ID: 609098 |
| Drug and gene relationship at DGIdb | |||
FBXO25 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04068 | FoxO signaling pathway |
Expression of FBXO25:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FBXO25 | 26260 | 225591_at | 0.1693 | 0.4786 | |
| GSE26886 | FBXO25 | 26260 | 225591_at | -0.5908 | 0.0002 | |
| GSE45670 | FBXO25 | 26260 | 225591_at | -0.0552 | 0.7931 | |
| GSE63941 | FBXO25 | 26260 | 225591_at | -0.5089 | 0.4287 | |
| GSE77861 | FBXO25 | 26260 | 225591_at | 0.0637 | 0.8209 | |
| GSE97050 | FBXO25 | 26260 | A_23_P94159 | -0.2032 | 0.4872 | |
| SRP007169 | FBXO25 | 26260 | RNAseq | -0.5815 | 0.0811 | |
| SRP008496 | FBXO25 | 26260 | RNAseq | -0.4491 | 0.0899 | |
| SRP064894 | FBXO25 | 26260 | RNAseq | -0.0634 | 0.7927 | |
| SRP133303 | FBXO25 | 26260 | RNAseq | -0.4863 | 0.0073 | |
| SRP159526 | FBXO25 | 26260 | RNAseq | -0.1203 | 0.5388 | |
| SRP193095 | FBXO25 | 26260 | RNAseq | -0.6557 | 0.0000 | |
| SRP219564 | FBXO25 | 26260 | RNAseq | -0.1260 | 0.6810 | |
| TCGA | FBXO25 | 26260 | RNAseq | -0.2125 | 0.0023 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by FBXO25 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of FBXO25:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FBXO25 | 26260 | 6 | 12 | 12 | |
| GSE20123 | FBXO25 | 26260 | 6 | 12 | 12 | |
| GSE43470 | FBXO25 | 26260 | 5 | 8 | 30 | |
| GSE46452 | FBXO25 | 26260 | 12 | 14 | 33 | |
| GSE47630 | FBXO25 | 26260 | 9 | 9 | 22 | |
| GSE54993 | FBXO25 | 26260 | 5 | 14 | 51 | |
| GSE54994 | FBXO25 | 26260 | 10 | 18 | 25 | |
| GSE60625 | FBXO25 | 26260 | 3 | 0 | 8 | |
| GSE74703 | FBXO25 | 26260 | 5 | 6 | 25 | |
| GSE74704 | FBXO25 | 26260 | 5 | 7 | 8 | |
| TCGA | FBXO25 | 26260 | 16 | 40 | 40 |
Total number of gains: 82; Total number of losses: 140; Total Number of normals: 266.
Somatic mutations of FBXO25:
Generating mutation plots.
Highly correlated genes for FBXO25:
Showing all 15 correlated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FBXO25 | POMT2 | 0.733573 | 3 | 0 | 3 |
| FBXO25 | ZNF264 | 0.721492 | 3 | 0 | 3 |
| FBXO25 | DNAJB2 | 0.697892 | 3 | 0 | 3 |
| FBXO25 | SSH3 | 0.679208 | 3 | 0 | 3 |
| FBXO25 | KCP | 0.666369 | 3 | 0 | 3 |
| FBXO25 | HES2 | 0.623568 | 3 | 0 | 3 |
| FBXO25 | MAP3K9 | 0.616574 | 3 | 0 | 3 |
| FBXO25 | CLCN6 | 0.61271 | 4 | 0 | 3 |
| FBXO25 | HES5 | 0.606616 | 3 | 0 | 3 |
| FBXO25 | LRFN4 | 0.592375 | 4 | 0 | 3 |
| FBXO25 | DCAF4 | 0.581894 | 3 | 0 | 3 |
| FBXO25 | MANBAL | 0.580153 | 3 | 0 | 3 |
| FBXO25 | SLC23A3 | 0.557364 | 3 | 0 | 3 |
| FBXO25 | TGFA | 0.543514 | 3 | 0 | 3 |
| FBXO25 | KCTD5 | 0.525781 | 3 | 0 | 3 |
For details and further investigation, click here
