| Full name: chloride voltage-gated channel 6 | Alias Symbol: CLC-6|KIAA0046|ClC-6 | ||
| Type: protein-coding gene | Cytoband: 1p36.22 | ||
| Entrez ID: 1185 | HGNC ID: HGNC:2024 | Ensembl Gene: ENSG00000011021 | OMIM ID: 602726 |
| Drug and gene relationship at DGIdb | |||
Expression of CLCN6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CLCN6 | 1185 | 203950_s_at | 0.0818 | 0.8316 | |
| GSE20347 | CLCN6 | 1185 | 203950_s_at | 0.1446 | 0.1613 | |
| GSE23400 | CLCN6 | 1185 | 203950_s_at | 0.0811 | 0.0258 | |
| GSE26886 | CLCN6 | 1185 | 203950_s_at | 0.2055 | 0.1727 | |
| GSE29001 | CLCN6 | 1185 | 203950_s_at | 0.4095 | 0.1651 | |
| GSE38129 | CLCN6 | 1185 | 203950_s_at | -0.1024 | 0.4886 | |
| GSE45670 | CLCN6 | 1185 | 203950_s_at | -0.1041 | 0.5671 | |
| GSE53622 | CLCN6 | 1185 | 113059 | 0.0676 | 0.4954 | |
| GSE53624 | CLCN6 | 1185 | 113059 | 0.2767 | 0.0001 | |
| GSE63941 | CLCN6 | 1185 | 203950_s_at | -1.0435 | 0.0022 | |
| GSE77861 | CLCN6 | 1185 | 203950_s_at | 0.1045 | 0.5077 | |
| GSE97050 | CLCN6 | 1185 | A_33_P3270228 | 0.2418 | 0.3476 | |
| SRP007169 | CLCN6 | 1185 | RNAseq | 1.4038 | 0.0434 | |
| SRP064894 | CLCN6 | 1185 | RNAseq | 0.4320 | 0.0618 | |
| SRP133303 | CLCN6 | 1185 | RNAseq | -0.0400 | 0.8239 | |
| SRP159526 | CLCN6 | 1185 | RNAseq | 0.1490 | 0.6935 | |
| SRP193095 | CLCN6 | 1185 | RNAseq | 0.6513 | 0.0000 | |
| SRP219564 | CLCN6 | 1185 | RNAseq | 0.1688 | 0.4342 | |
| TCGA | CLCN6 | 1185 | RNAseq | -0.1850 | 0.0008 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by CLCN6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CLCN6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CLCN6 | 1185 | 0 | 5 | 25 | |
| GSE20123 | CLCN6 | 1185 | 0 | 4 | 26 | |
| GSE43470 | CLCN6 | 1185 | 4 | 6 | 33 | |
| GSE46452 | CLCN6 | 1185 | 7 | 1 | 51 | |
| GSE47630 | CLCN6 | 1185 | 8 | 4 | 28 | |
| GSE54993 | CLCN6 | 1185 | 3 | 1 | 66 | |
| GSE54994 | CLCN6 | 1185 | 11 | 4 | 38 | |
| GSE60625 | CLCN6 | 1185 | 0 | 0 | 11 | |
| GSE74703 | CLCN6 | 1185 | 3 | 4 | 29 | |
| GSE74704 | CLCN6 | 1185 | 0 | 0 | 20 | |
| TCGA | CLCN6 | 1185 | 10 | 22 | 64 |
Total number of gains: 46; Total number of losses: 51; Total Number of normals: 391.
Somatic mutations of CLCN6:
Generating mutation plots.
Highly correlated genes for CLCN6:
Showing top 20/151 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CLCN6 | ZNF205 | 0.762821 | 4 | 0 | 4 |
| CLCN6 | ZNF777 | 0.706198 | 4 | 0 | 3 |
| CLCN6 | ZNF282 | 0.690169 | 3 | 0 | 3 |
| CLCN6 | PCYT2 | 0.690087 | 3 | 0 | 3 |
| CLCN6 | ALDH8A1 | 0.68253 | 3 | 0 | 3 |
| CLCN6 | SH2D5 | 0.678757 | 3 | 0 | 3 |
| CLCN6 | FAM110B | 0.676516 | 4 | 0 | 3 |
| CLCN6 | AMPD2 | 0.670395 | 5 | 0 | 3 |
| CLCN6 | KLHL26 | 0.669227 | 6 | 0 | 5 |
| CLCN6 | MAGEL2 | 0.668371 | 3 | 0 | 3 |
| CLCN6 | PRSS53 | 0.666526 | 3 | 0 | 3 |
| CLCN6 | TBC1D10B | 0.648065 | 5 | 0 | 4 |
| CLCN6 | SIGIRR | 0.645398 | 5 | 0 | 4 |
| CLCN6 | GSTM5 | 0.644163 | 4 | 0 | 3 |
| CLCN6 | ADAMTS6 | 0.642709 | 4 | 0 | 3 |
| CLCN6 | SCLY | 0.64027 | 4 | 0 | 3 |
| CLCN6 | GNAL | 0.639021 | 4 | 0 | 3 |
| CLCN6 | LIF | 0.63889 | 4 | 0 | 3 |
| CLCN6 | FAM171A1 | 0.635827 | 3 | 0 | 3 |
| CLCN6 | CADPS | 0.635509 | 4 | 0 | 3 |
For details and further investigation, click here
