DCAF4

 

Full name: DDB1 and CUL4 associated factor 4 Alias Symbol: DKFZp434K114
Type: protein-coding gene Cytoband: 14q24.2
Entrez ID: 26094 HGNC ID: HGNC:20229 Ensembl Gene: ENSG00000119599 OMIM ID: 616372
Drug and gene relationship at DGIdb

 

Expression of DCAF4:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 DCAF4 26094 226938_at 0.7487 0.3238
GSE20347 DCAF4 26094 214758_at -0.0569 0.6873
GSE23400 DCAF4 26094 214758_at -0.0943 0.0209
GSE26886 DCAF4 26094 226938_at 0.5641 0.1063
GSE29001 DCAF4 26094 214758_at 0.0172 0.9350
GSE38129 DCAF4 26094 214758_at -0.0477 0.7623
GSE45670 DCAF4 26094 226938_at 0.4352 0.0204
GSE53622 DCAF4 26094 140608 0.5989 0.0000
GSE53624 DCAF4 26094 140608 0.6870 0.0000
GSE63941 DCAF4 26094 226938_at 0.1959 0.7308
GSE77861 DCAF4 26094 226938_at 0.0805 0.7482
GSE97050 DCAF4 26094 A_33_P3419234 0.0255 0.9165
SRP007169 DCAF4 26094 RNAseq 1.3707 0.0317
SRP008496 DCAF4 26094 RNAseq 1.4229 0.0041
SRP064894 DCAF4 26094 RNAseq 0.7478 0.0015
SRP133303 DCAF4 26094 RNAseq 0.3470 0.0638
SRP159526 DCAF4 26094 RNAseq 0.1691 0.6287
SRP193095 DCAF4 26094 RNAseq 0.6188 0.0001
SRP219564 DCAF4 26094 RNAseq 0.8683 0.0456
TCGA DCAF4 26094 RNAseq 0.1536 0.0480

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by DCAF4 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of DCAF4:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 DCAF4 26094 8 2 20
GSE20123 DCAF4 26094 8 2 20
GSE43470 DCAF4 26094 8 3 32
GSE46452 DCAF4 26094 16 3 40
GSE47630 DCAF4 26094 11 8 21
GSE54993 DCAF4 26094 3 8 59
GSE54994 DCAF4 26094 19 4 30
GSE60625 DCAF4 26094 0 2 9
GSE74703 DCAF4 26094 7 3 26
GSE74704 DCAF4 26094 3 2 15
TCGA DCAF4 26094 31 16 49

Total number of gains: 114; Total number of losses: 53; Total Number of normals: 321.  

 

Somatic mutations of DCAF4:

 

Generating mutation plots.

 

Highly correlated genes for DCAF4:

 

Showing top 20/162 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
DCAF4PAPLN0.659282403
DCAF4COL27A10.658341403
DCAF4TRIM110.649689303
DCAF4NAT8B0.624652303
DCAF4BRMS10.617242403
DCAF4OTUD40.616127403
DCAF4PLEKHG40.615344403
DCAF4TIGD70.612269303
DCAF4GPRIN10.61049403
DCAF4RAD520.603587303
DCAF4REM20.601405303
DCAF4AREL10.599381604
DCAF4ZNF5110.596892303
DCAF4TTLL50.596071604
DCAF4NHLH10.590089303
DCAF4GMFB0.585815705
DCAF4GEMIN20.583774604
DCAF4CMSS10.583271403
DCAF4TMEM2600.582091604
DCAF4ALDH16A10.582007403

For details and further investigation, click here