| Full name: mitogen-activated protein kinase kinase kinase 9 | Alias Symbol: PRKE1|MEKK9 | ||
| Type: protein-coding gene | Cytoband: 14q24.2 | ||
| Entrez ID: 4293 | HGNC ID: HGNC:6861 | Ensembl Gene: ENSG00000006432 | OMIM ID: 600136 |
| Drug and gene relationship at DGIdb | |||
Expression of MAP3K9:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MAP3K9 | 4293 | 213927_at | 0.6758 | 0.5862 | |
| GSE20347 | MAP3K9 | 4293 | 213927_at | -0.9742 | 0.0025 | |
| GSE23400 | MAP3K9 | 4293 | 213927_at | -1.0937 | 0.0000 | |
| GSE26886 | MAP3K9 | 4293 | 213927_at | -3.7572 | 0.0000 | |
| GSE29001 | MAP3K9 | 4293 | 213927_at | -1.2386 | 0.0023 | |
| GSE38129 | MAP3K9 | 4293 | 213927_at | -0.6562 | 0.0627 | |
| GSE45670 | MAP3K9 | 4293 | 213927_at | -0.1410 | 0.6292 | |
| GSE53622 | MAP3K9 | 4293 | 44479 | -0.9800 | 0.0000 | |
| GSE53624 | MAP3K9 | 4293 | 44479 | -1.2938 | 0.0000 | |
| GSE63941 | MAP3K9 | 4293 | 213927_at | 2.2208 | 0.0021 | |
| GSE77861 | MAP3K9 | 4293 | 213927_at | -1.3926 | 0.0011 | |
| GSE97050 | MAP3K9 | 4293 | A_33_P3379571 | 0.0956 | 0.8138 | |
| SRP007169 | MAP3K9 | 4293 | RNAseq | -2.6282 | 0.0000 | |
| SRP008496 | MAP3K9 | 4293 | RNAseq | -2.6201 | 0.0000 | |
| SRP064894 | MAP3K9 | 4293 | RNAseq | -1.7335 | 0.0000 | |
| SRP133303 | MAP3K9 | 4293 | RNAseq | -1.6215 | 0.0000 | |
| SRP159526 | MAP3K9 | 4293 | RNAseq | -1.8575 | 0.0000 | |
| SRP193095 | MAP3K9 | 4293 | RNAseq | -1.7731 | 0.0000 | |
| SRP219564 | MAP3K9 | 4293 | RNAseq | -1.7136 | 0.0454 | |
| TCGA | MAP3K9 | 4293 | RNAseq | -0.0110 | 0.9290 |
Upregulated datasets: 1; Downregulated datasets: 12.
Survival by MAP3K9 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MAP3K9:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MAP3K9 | 4293 | 8 | 3 | 19 | |
| GSE20123 | MAP3K9 | 4293 | 8 | 3 | 19 | |
| GSE43470 | MAP3K9 | 4293 | 8 | 3 | 32 | |
| GSE46452 | MAP3K9 | 4293 | 16 | 3 | 40 | |
| GSE47630 | MAP3K9 | 4293 | 11 | 9 | 20 | |
| GSE54993 | MAP3K9 | 4293 | 3 | 9 | 58 | |
| GSE54994 | MAP3K9 | 4293 | 18 | 5 | 30 | |
| GSE60625 | MAP3K9 | 4293 | 0 | 2 | 9 | |
| GSE74703 | MAP3K9 | 4293 | 7 | 3 | 26 | |
| GSE74704 | MAP3K9 | 4293 | 3 | 3 | 14 | |
| TCGA | MAP3K9 | 4293 | 32 | 16 | 48 |
Total number of gains: 114; Total number of losses: 59; Total Number of normals: 315.
Somatic mutations of MAP3K9:
Generating mutation plots.
Highly correlated genes for MAP3K9:
Showing top 20/812 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MAP3K9 | SHQ1 | 0.820291 | 3 | 0 | 3 |
| MAP3K9 | ATG9B | 0.80685 | 5 | 0 | 5 |
| MAP3K9 | ATP6V1C2 | 0.794329 | 3 | 0 | 3 |
| MAP3K9 | FBXO34 | 0.789999 | 11 | 0 | 11 |
| MAP3K9 | ZNF780A | 0.768696 | 3 | 0 | 3 |
| MAP3K9 | FAM163B | 0.766674 | 3 | 0 | 3 |
| MAP3K9 | SFTA2 | 0.762987 | 3 | 0 | 3 |
| MAP3K9 | SNORA68 | 0.760018 | 3 | 0 | 3 |
| MAP3K9 | KIAA1522 | 0.759453 | 3 | 0 | 3 |
| MAP3K9 | SH2D1B | 0.758352 | 3 | 0 | 3 |
| MAP3K9 | KRT78 | 0.75672 | 5 | 0 | 5 |
| MAP3K9 | PRSS2 | 0.752863 | 8 | 0 | 8 |
| MAP3K9 | SPAG17 | 0.748853 | 3 | 0 | 3 |
| MAP3K9 | TTC9 | 0.748454 | 10 | 0 | 9 |
| MAP3K9 | KAZN | 0.747676 | 10 | 0 | 10 |
| MAP3K9 | SCNN1B | 0.747103 | 10 | 0 | 10 |
| MAP3K9 | CLIC3 | 0.746741 | 7 | 0 | 7 |
| MAP3K9 | SPNS2 | 0.744259 | 4 | 0 | 3 |
| MAP3K9 | VSIG10L | 0.743915 | 6 | 0 | 6 |
| MAP3K9 | PRSS27 | 0.743635 | 7 | 0 | 7 |
For details and further investigation, click here
