| Full name: FMR1 autosomal homolog 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 3q26.33 | ||
| Entrez ID: 8087 | HGNC ID: HGNC:4023 | Ensembl Gene: ENSG00000114416 | OMIM ID: 600819 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of FXR1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FXR1 | 8087 | 201637_s_at | 0.4924 | 0.0967 | |
| GSE20347 | FXR1 | 8087 | 201637_s_at | 0.9170 | 0.0000 | |
| GSE23400 | FXR1 | 8087 | 201637_s_at | 1.1948 | 0.0000 | |
| GSE26886 | FXR1 | 8087 | 201637_s_at | 1.0974 | 0.0000 | |
| GSE29001 | FXR1 | 8087 | 201637_s_at | 0.8499 | 0.0009 | |
| GSE38129 | FXR1 | 8087 | 201637_s_at | 0.9467 | 0.0000 | |
| GSE45670 | FXR1 | 8087 | 201637_s_at | 0.5553 | 0.0092 | |
| GSE63941 | FXR1 | 8087 | 201637_s_at | 1.0741 | 0.0402 | |
| GSE77861 | FXR1 | 8087 | 201637_s_at | 0.8063 | 0.0150 | |
| GSE97050 | FXR1 | 8087 | A_33_P3387300 | 0.4828 | 0.1453 | |
| SRP007169 | FXR1 | 8087 | RNAseq | 2.8769 | 0.0000 | |
| SRP008496 | FXR1 | 8087 | RNAseq | 2.6959 | 0.0000 | |
| SRP064894 | FXR1 | 8087 | RNAseq | 0.7359 | 0.0000 | |
| SRP133303 | FXR1 | 8087 | RNAseq | 1.0817 | 0.0000 | |
| SRP159526 | FXR1 | 8087 | RNAseq | 1.3835 | 0.0001 | |
| SRP193095 | FXR1 | 8087 | RNAseq | 0.7139 | 0.0000 | |
| SRP219564 | FXR1 | 8087 | RNAseq | 0.1896 | 0.6230 | |
| TCGA | FXR1 | 8087 | RNAseq | 0.2271 | 0.0000 |
Upregulated datasets: 7; Downregulated datasets: 0.
Survival by FXR1 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of FXR1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FXR1 | 8087 | 26 | 0 | 4 | |
| GSE20123 | FXR1 | 8087 | 26 | 0 | 4 | |
| GSE43470 | FXR1 | 8087 | 24 | 0 | 19 | |
| GSE46452 | FXR1 | 8087 | 19 | 1 | 39 | |
| GSE47630 | FXR1 | 8087 | 27 | 2 | 11 | |
| GSE54993 | FXR1 | 8087 | 1 | 18 | 51 | |
| GSE54994 | FXR1 | 8087 | 41 | 0 | 12 | |
| GSE60625 | FXR1 | 8087 | 0 | 6 | 5 | |
| GSE74703 | FXR1 | 8087 | 20 | 0 | 16 | |
| GSE74704 | FXR1 | 8087 | 17 | 0 | 3 | |
| TCGA | FXR1 | 8087 | 78 | 0 | 18 |
Total number of gains: 279; Total number of losses: 27; Total Number of normals: 182.
Somatic mutations of FXR1:
Generating mutation plots.
Highly correlated genes for FXR1:
Showing top 20/1949 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FXR1 | ACTL6A | 0.815246 | 11 | 0 | 11 |
| FXR1 | MRPL47 | 0.812163 | 7 | 0 | 7 |
| FXR1 | BOD1 | 0.801482 | 4 | 0 | 4 |
| FXR1 | PFDN2 | 0.800014 | 9 | 0 | 9 |
| FXR1 | AMMECR1L | 0.798891 | 5 | 0 | 5 |
| FXR1 | MRPL36 | 0.79155 | 4 | 0 | 4 |
| FXR1 | U2SURP | 0.790107 | 10 | 0 | 9 |
| FXR1 | HMBOX1 | 0.780016 | 3 | 0 | 3 |
| FXR1 | HLTF | 0.778816 | 11 | 0 | 11 |
| FXR1 | ELOF1 | 0.776952 | 3 | 0 | 3 |
| FXR1 | CHIC1 | 0.771443 | 3 | 0 | 3 |
| FXR1 | ERP29 | 0.768244 | 3 | 0 | 3 |
| FXR1 | TP53I13 | 0.767318 | 4 | 0 | 4 |
| FXR1 | SLC25A32 | 0.76619 | 9 | 0 | 9 |
| FXR1 | GMPS | 0.765724 | 11 | 0 | 10 |
| FXR1 | MB21D2 | 0.764924 | 4 | 0 | 4 |
| FXR1 | PSMB4 | 0.762548 | 10 | 0 | 10 |
| FXR1 | NBAS | 0.75954 | 3 | 0 | 3 |
| FXR1 | LRP12 | 0.759278 | 9 | 0 | 8 |
| FXR1 | MRPS26 | 0.757995 | 3 | 0 | 3 |
For details and further investigation, click here
