ACTL6A

 

Full name: actin like 6A Alias Symbol: Actl6|BAF53A|Arp4|Baf53a|INO80K
Type: protein-coding gene Cytoband: 3q26.33
Entrez ID: 86 HGNC ID: HGNC:24124 Ensembl Gene: ENSG00000136518 OMIM ID: 604958
Drug and gene relationship at DGIdb

 

Expression of ACTL6A:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ACTL6A 86 202666_s_at 0.9822 0.0489
GSE20347 ACTL6A 86 202666_s_at 1.4660 0.0000
GSE23400 ACTL6A 86 202666_s_at 1.3859 0.0000
GSE26886 ACTL6A 86 202666_s_at 1.3882 0.0000
GSE29001 ACTL6A 86 202666_s_at 1.3104 0.0006
GSE38129 ACTL6A 86 202666_s_at 1.5763 0.0000
GSE45670 ACTL6A 86 202666_s_at 1.0860 0.0001
GSE53622 ACTL6A 86 9908 1.2157 0.0000
GSE53624 ACTL6A 86 9908 1.4313 0.0000
GSE63941 ACTL6A 86 202666_s_at 1.4247 0.0034
GSE77861 ACTL6A 86 202666_s_at 0.8834 0.0100
GSE97050 ACTL6A 86 A_23_P69249 0.8013 0.1502
SRP007169 ACTL6A 86 RNAseq 2.8885 0.0000
SRP008496 ACTL6A 86 RNAseq 2.6306 0.0000
SRP064894 ACTL6A 86 RNAseq 1.2799 0.0000
SRP133303 ACTL6A 86 RNAseq 1.5789 0.0000
SRP159526 ACTL6A 86 RNAseq 1.6600 0.0000
SRP193095 ACTL6A 86 RNAseq 0.9126 0.0000
SRP219564 ACTL6A 86 RNAseq 1.0026 0.0515
TCGA ACTL6A 86 RNAseq 0.5198 0.0000

Upregulated datasets: 14; Downregulated datasets: 0.  

 

Survival by ACTL6A expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ACTL6A:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ACTL6A 86 25 0 5
GSE20123 ACTL6A 86 25 0 5
GSE43470 ACTL6A 86 24 0 19
GSE46452 ACTL6A 86 19 1 39
GSE47630 ACTL6A 86 27 2 11
GSE54993 ACTL6A 86 1 18 51
GSE54994 ACTL6A 86 41 0 12
GSE60625 ACTL6A 86 0 6 5
GSE74703 ACTL6A 86 20 0 16
GSE74704 ACTL6A 86 16 0 4
TCGA ACTL6A 86 78 0 18

Total number of gains: 276; Total number of losses: 27; Total Number of normals: 185.  

 

Somatic mutations of ACTL6A:

 

Generating mutation plots.

 

Highly correlated genes for ACTL6A:

 

Showing top 20/2201 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ACTL6AMRPL470.868207909
ACTL6ARFC40.84764513013
ACTL6AECT20.84707612012
ACTL6AATR0.8283311011
ACTL6ALRRC580.824456505
ACTL6AMMS22L0.823912303
ACTL6AGMPS0.81685713013
ACTL6ACBX30.81532910010
ACTL6AFXR10.81524611011
ACTL6AATP13A30.80977811011
ACTL6APSME40.79792711011
ACTL6AU2SURP0.79752410010
ACTL6AUBE2J20.795443303
ACTL6ATOPBP10.78869213012
ACTL6AE2F60.78794611011
ACTL6AMCM20.78691312012
ACTL6ACMSS10.78236707
ACTL6AFAM89A0.780665303
ACTL6APOLR2H0.77950213013
ACTL6AATAD20.77926312011

For details and further investigation, click here