| Full name: LDL receptor related protein 12 | Alias Symbol: ST7|FLJ12929 | ||
| Type: protein-coding gene | Cytoband: 8q22.3 | ||
| Entrez ID: 29967 | HGNC ID: HGNC:31708 | Ensembl Gene: ENSG00000147650 | OMIM ID: 618299 |
| Drug and gene relationship at DGIdb | |||
Expression of LRP12:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LRP12 | 29967 | 219631_at | 1.9348 | 0.0580 | |
| GSE20347 | LRP12 | 29967 | 219631_at | 1.8992 | 0.0000 | |
| GSE23400 | LRP12 | 29967 | 219631_at | 1.1561 | 0.0000 | |
| GSE26886 | LRP12 | 29967 | 219631_at | 2.2975 | 0.0000 | |
| GSE29001 | LRP12 | 29967 | 219631_at | 1.8417 | 0.0000 | |
| GSE38129 | LRP12 | 29967 | 219631_at | 1.8857 | 0.0000 | |
| GSE45670 | LRP12 | 29967 | 219631_at | 1.1382 | 0.0234 | |
| GSE53622 | LRP12 | 29967 | 82584 | 1.9162 | 0.0000 | |
| GSE53624 | LRP12 | 29967 | 82584 | 2.3454 | 0.0000 | |
| GSE63941 | LRP12 | 29967 | 219631_at | -1.6611 | 0.1193 | |
| GSE77861 | LRP12 | 29967 | 219631_at | 1.4543 | 0.0010 | |
| GSE97050 | LRP12 | 29967 | A_23_P8906 | 0.9750 | 0.0706 | |
| SRP007169 | LRP12 | 29967 | RNAseq | 3.0773 | 0.0000 | |
| SRP008496 | LRP12 | 29967 | RNAseq | 3.3528 | 0.0000 | |
| SRP064894 | LRP12 | 29967 | RNAseq | 2.2809 | 0.0000 | |
| SRP133303 | LRP12 | 29967 | RNAseq | 1.9360 | 0.0000 | |
| SRP159526 | LRP12 | 29967 | RNAseq | 2.2509 | 0.0000 | |
| SRP193095 | LRP12 | 29967 | RNAseq | 2.5183 | 0.0000 | |
| SRP219564 | LRP12 | 29967 | RNAseq | 1.1956 | 0.0053 | |
| TCGA | LRP12 | 29967 | RNAseq | 0.4769 | 0.0000 |
Upregulated datasets: 16; Downregulated datasets: 0.
Survival by LRP12 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LRP12:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LRP12 | 29967 | 16 | 0 | 14 | |
| GSE20123 | LRP12 | 29967 | 17 | 0 | 13 | |
| GSE43470 | LRP12 | 29967 | 22 | 0 | 21 | |
| GSE46452 | LRP12 | 29967 | 24 | 0 | 35 | |
| GSE47630 | LRP12 | 29967 | 24 | 0 | 16 | |
| GSE54993 | LRP12 | 29967 | 0 | 20 | 50 | |
| GSE54994 | LRP12 | 29967 | 37 | 1 | 15 | |
| GSE60625 | LRP12 | 29967 | 0 | 4 | 7 | |
| GSE74703 | LRP12 | 29967 | 19 | 0 | 17 | |
| GSE74704 | LRP12 | 29967 | 11 | 0 | 9 | |
| TCGA | LRP12 | 29967 | 60 | 1 | 35 |
Total number of gains: 230; Total number of losses: 26; Total Number of normals: 232.
Somatic mutations of LRP12:
Generating mutation plots.
Highly correlated genes for LRP12:
Showing top 20/2049 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LRP12 | ZFHX3 | 0.816376 | 3 | 0 | 3 |
| LRP12 | FAM89A | 0.808349 | 3 | 0 | 3 |
| LRP12 | LPCAT1 | 0.798764 | 11 | 0 | 11 |
| LRP12 | FMNL2 | 0.795597 | 7 | 0 | 7 |
| LRP12 | SLC25A32 | 0.792735 | 12 | 0 | 12 |
| LRP12 | PYCR2 | 0.78218 | 3 | 0 | 3 |
| LRP12 | ITGAV | 0.776865 | 11 | 0 | 11 |
| LRP12 | BRAT1 | 0.776733 | 7 | 0 | 7 |
| LRP12 | SPON2 | 0.771801 | 3 | 0 | 3 |
| LRP12 | POLRMT | 0.767073 | 3 | 0 | 3 |
| LRP12 | RAB34 | 0.763893 | 3 | 0 | 3 |
| LRP12 | CKAP5 | 0.76329 | 11 | 0 | 11 |
| LRP12 | STK3 | 0.763274 | 11 | 0 | 11 |
| LRP12 | ATP6V1C1 | 0.762023 | 11 | 0 | 11 |
| LRP12 | SERPINH1 | 0.761071 | 11 | 0 | 10 |
| LRP12 | TGFBI | 0.759378 | 11 | 0 | 11 |
| LRP12 | FXR1 | 0.759278 | 9 | 0 | 8 |
| LRP12 | DPY19L1 | 0.758543 | 12 | 0 | 11 |
| LRP12 | FAM89B | 0.756778 | 3 | 0 | 3 |
| LRP12 | CERS2 | 0.754508 | 10 | 0 | 9 |
For details and further investigation, click here
