| Full name: guanine monophosphate synthase | Alias Symbol: GATD7 | ||
| Type: protein-coding gene | Cytoband: 3q25.31 | ||
| Entrez ID: 8833 | HGNC ID: HGNC:4378 | Ensembl Gene: ENSG00000163655 | OMIM ID: 600358 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of GMPS:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GMPS | 8833 | 214431_at | 1.2597 | 0.0182 | |
| GSE20347 | GMPS | 8833 | 214431_at | 1.0222 | 0.0000 | |
| GSE23400 | GMPS | 8833 | 214431_at | 1.1986 | 0.0000 | |
| GSE26886 | GMPS | 8833 | 214431_at | 0.9630 | 0.0000 | |
| GSE29001 | GMPS | 8833 | 214431_at | 1.4211 | 0.0000 | |
| GSE38129 | GMPS | 8833 | 214431_at | 1.0928 | 0.0000 | |
| GSE45670 | GMPS | 8833 | 214431_at | 0.7802 | 0.0006 | |
| GSE53622 | GMPS | 8833 | 33676 | 1.0124 | 0.0000 | |
| GSE53624 | GMPS | 8833 | 33676 | 1.3328 | 0.0000 | |
| GSE63941 | GMPS | 8833 | 214431_at | 1.1659 | 0.0214 | |
| GSE77861 | GMPS | 8833 | 214431_at | 0.9986 | 0.0022 | |
| GSE97050 | GMPS | 8833 | A_23_P21033 | 0.3968 | 0.2038 | |
| SRP007169 | GMPS | 8833 | RNAseq | 1.5606 | 0.0001 | |
| SRP008496 | GMPS | 8833 | RNAseq | 1.7592 | 0.0000 | |
| SRP064894 | GMPS | 8833 | RNAseq | 1.0842 | 0.0000 | |
| SRP133303 | GMPS | 8833 | RNAseq | 0.8439 | 0.0000 | |
| SRP159526 | GMPS | 8833 | RNAseq | 1.9974 | 0.0000 | |
| SRP193095 | GMPS | 8833 | RNAseq | 0.8408 | 0.0000 | |
| SRP219564 | GMPS | 8833 | RNAseq | 0.7626 | 0.0195 | |
| TCGA | GMPS | 8833 | RNAseq | 0.3937 | 0.0000 |
Upregulated datasets: 12; Downregulated datasets: 0.
Survival by GMPS expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GMPS:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GMPS | 8833 | 21 | 1 | 8 | |
| GSE20123 | GMPS | 8833 | 21 | 1 | 8 | |
| GSE43470 | GMPS | 8833 | 23 | 0 | 20 | |
| GSE46452 | GMPS | 8833 | 18 | 2 | 39 | |
| GSE47630 | GMPS | 8833 | 19 | 3 | 18 | |
| GSE54993 | GMPS | 8833 | 1 | 11 | 58 | |
| GSE54994 | GMPS | 8833 | 38 | 1 | 14 | |
| GSE60625 | GMPS | 8833 | 0 | 6 | 5 | |
| GSE74703 | GMPS | 8833 | 20 | 0 | 16 | |
| GSE74704 | GMPS | 8833 | 14 | 0 | 6 | |
| TCGA | GMPS | 8833 | 73 | 1 | 22 |
Total number of gains: 248; Total number of losses: 26; Total Number of normals: 214.
Somatic mutations of GMPS:
Generating mutation plots.
Highly correlated genes for GMPS:
Showing top 20/2128 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GMPS | ACTL6A | 0.816857 | 13 | 0 | 13 |
| GMPS | ECT2 | 0.81547 | 11 | 0 | 11 |
| GMPS | RUVBL1 | 0.807489 | 13 | 0 | 13 |
| GMPS | TOPBP1 | 0.805156 | 12 | 0 | 12 |
| GMPS | SNRPG | 0.79838 | 12 | 0 | 12 |
| GMPS | PPP1R16A | 0.796973 | 3 | 0 | 3 |
| GMPS | ACLY | 0.794482 | 11 | 0 | 11 |
| GMPS | PSME4 | 0.793924 | 11 | 0 | 11 |
| GMPS | MRPL47 | 0.790681 | 8 | 0 | 8 |
| GMPS | U2SURP | 0.788908 | 10 | 0 | 10 |
| GMPS | MCM2 | 0.788726 | 12 | 0 | 12 |
| GMPS | RFC4 | 0.788671 | 13 | 0 | 13 |
| GMPS | DNAJC2 | 0.787804 | 11 | 0 | 11 |
| GMPS | ALKBH6 | 0.787535 | 5 | 0 | 5 |
| GMPS | MMS22L | 0.787365 | 3 | 0 | 3 |
| GMPS | SLC33A1 | 0.786008 | 13 | 0 | 13 |
| GMPS | MYBL2 | 0.785403 | 12 | 0 | 11 |
| GMPS | PFDN2 | 0.780461 | 11 | 0 | 11 |
| GMPS | PSMD2 | 0.779652 | 12 | 0 | 12 |
| GMPS | UMPS | 0.778756 | 11 | 0 | 11 |
For details and further investigation, click here
