PSMB4

 

Full name: proteasome subunit beta 4 Alias Symbol: HN3|PROS26
Type: protein-coding gene Cytoband: 1q21.3
Entrez ID: 5692 HGNC ID: HGNC:9541 Ensembl Gene: ENSG00000159377 OMIM ID: 602177
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of PSMB4:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PSMB4 5692 202244_at 0.6373 0.0502
GSE20347 PSMB4 5692 202244_at 0.7652 0.0000
GSE23400 PSMB4 5692 202244_at 0.7146 0.0000
GSE26886 PSMB4 5692 202244_at 0.7335 0.0000
GSE29001 PSMB4 5692 202244_at 0.7266 0.0008
GSE38129 PSMB4 5692 202244_at 0.7369 0.0000
GSE45670 PSMB4 5692 202244_at 0.4624 0.0026
GSE53622 PSMB4 5692 23478 0.5670 0.0000
GSE53624 PSMB4 5692 23478 0.8621 0.0000
GSE63941 PSMB4 5692 202244_at 0.0214 0.9522
GSE77861 PSMB4 5692 202244_at 0.8938 0.0003
GSE97050 PSMB4 5692 A_23_P761 0.4685 0.1403
SRP007169 PSMB4 5692 RNAseq 0.1241 0.6988
SRP008496 PSMB4 5692 RNAseq 0.3629 0.0234
SRP064894 PSMB4 5692 RNAseq 0.7108 0.0026
SRP133303 PSMB4 5692 RNAseq 0.6462 0.0000
SRP159526 PSMB4 5692 RNAseq 1.1083 0.0000
SRP193095 PSMB4 5692 RNAseq 0.5891 0.0001
SRP219564 PSMB4 5692 RNAseq 0.6436 0.0942
TCGA PSMB4 5692 RNAseq 0.1932 0.0000

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by PSMB4 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PSMB4:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PSMB4 5692 15 0 15
GSE20123 PSMB4 5692 15 0 15
GSE43470 PSMB4 5692 6 1 36
GSE46452 PSMB4 5692 2 1 56
GSE47630 PSMB4 5692 14 0 26
GSE54993 PSMB4 5692 0 4 66
GSE54994 PSMB4 5692 15 0 38
GSE60625 PSMB4 5692 0 0 11
GSE74703 PSMB4 5692 6 1 29
GSE74704 PSMB4 5692 7 0 13
TCGA PSMB4 5692 37 2 57

Total number of gains: 117; Total number of losses: 9; Total Number of normals: 362.  

 

Somatic mutations of PSMB4:

 

Generating mutation plots.

 

Highly correlated genes for PSMB4:

 

Showing top 20/2334 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PSMB4SSBP40.798269505
PSMB4SLC39A30.788193404
PSMB4WDR810.786138505
PSMB4SNRPE0.78596811011
PSMB4GOLM10.784784505
PSMB4LRRC580.782516505
PSMB4MTERF30.775856808
PSMB4PRTFDC10.772445404
PSMB4GMPS0.76910912011
PSMB4ADAR0.76428412011
PSMB4UHMK10.763159707
PSMB4FXR10.76254810010
PSMB4ZNF2840.762195303
PSMB4TYW50.761364404
PSMB4TP53I130.760959606
PSMB4CPSF60.76001511010
PSMB4PPT10.75951711010
PSMB4ANP32E0.75840811011
PSMB4NUDCD10.757846606
PSMB4PRR120.756194303

For details and further investigation, click here