| Full name: helicase like transcription factor | Alias Symbol: HIP116A|HLTF1|RNF80 | ||
| Type: protein-coding gene | Cytoband: 3q24 | ||
| Entrez ID: 6596 | HGNC ID: HGNC:11099 | Ensembl Gene: ENSG00000071794 | OMIM ID: 603257 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of HLTF:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HLTF | 6596 | 202983_at | 1.5425 | 0.0240 | |
| GSE20347 | HLTF | 6596 | 202983_at | 1.8786 | 0.0000 | |
| GSE23400 | HLTF | 6596 | 202983_at | 1.4463 | 0.0000 | |
| GSE26886 | HLTF | 6596 | 202983_at | 1.9044 | 0.0000 | |
| GSE29001 | HLTF | 6596 | 202983_at | 1.8010 | 0.0016 | |
| GSE38129 | HLTF | 6596 | 202983_at | 1.3900 | 0.0000 | |
| GSE45670 | HLTF | 6596 | 202983_at | 0.7828 | 0.0045 | |
| GSE53622 | HLTF | 6596 | 136756 | 1.3813 | 0.0000 | |
| GSE53624 | HLTF | 6596 | 136756 | 1.4404 | 0.0000 | |
| GSE63941 | HLTF | 6596 | 202983_at | 0.5896 | 0.6405 | |
| GSE77861 | HLTF | 6596 | 202983_at | 1.1550 | 0.0277 | |
| GSE97050 | HLTF | 6596 | A_24_P277155 | 0.2033 | 0.6195 | |
| SRP007169 | HLTF | 6596 | RNAseq | 2.3014 | 0.0000 | |
| SRP008496 | HLTF | 6596 | RNAseq | 2.4748 | 0.0000 | |
| SRP064894 | HLTF | 6596 | RNAseq | 1.1962 | 0.0000 | |
| SRP133303 | HLTF | 6596 | RNAseq | 1.1867 | 0.0000 | |
| SRP159526 | HLTF | 6596 | RNAseq | 1.6626 | 0.0000 | |
| SRP193095 | HLTF | 6596 | RNAseq | 1.2327 | 0.0000 | |
| SRP219564 | HLTF | 6596 | RNAseq | 0.7909 | 0.1186 | |
| TCGA | HLTF | 6596 | RNAseq | 0.2258 | 0.0093 |
Upregulated datasets: 15; Downregulated datasets: 0.
Survival by HLTF expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HLTF:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HLTF | 6596 | 22 | 0 | 8 | |
| GSE20123 | HLTF | 6596 | 22 | 0 | 8 | |
| GSE43470 | HLTF | 6596 | 23 | 0 | 20 | |
| GSE46452 | HLTF | 6596 | 18 | 2 | 39 | |
| GSE47630 | HLTF | 6596 | 19 | 3 | 18 | |
| GSE54993 | HLTF | 6596 | 1 | 10 | 59 | |
| GSE54994 | HLTF | 6596 | 35 | 1 | 17 | |
| GSE60625 | HLTF | 6596 | 0 | 6 | 5 | |
| GSE74703 | HLTF | 6596 | 20 | 0 | 16 | |
| GSE74704 | HLTF | 6596 | 15 | 0 | 5 | |
| TCGA | HLTF | 6596 | 70 | 2 | 24 |
Total number of gains: 245; Total number of losses: 24; Total Number of normals: 219.
Somatic mutations of HLTF:
Generating mutation plots.
Highly correlated genes for HLTF:
Showing top 20/2287 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HLTF | LRRC58 | 0.849467 | 5 | 0 | 5 |
| HLTF | HMBOX1 | 0.839395 | 3 | 0 | 3 |
| HLTF | RFC4 | 0.796616 | 11 | 0 | 11 |
| HLTF | U2SURP | 0.793316 | 10 | 0 | 9 |
| HLTF | RAB34 | 0.787046 | 3 | 0 | 3 |
| HLTF | FXR1 | 0.778816 | 11 | 0 | 11 |
| HLTF | PLXNA1 | 0.775557 | 11 | 0 | 11 |
| HLTF | PXYLP1 | 0.76586 | 6 | 0 | 6 |
| HLTF | HPS3 | 0.763799 | 6 | 0 | 6 |
| HLTF | SLC25A36 | 0.757031 | 12 | 0 | 12 |
| HLTF | CMSS1 | 0.756883 | 6 | 0 | 6 |
| HLTF | MSH6 | 0.756089 | 12 | 0 | 12 |
| HLTF | ATR | 0.754495 | 11 | 0 | 10 |
| HLTF | PIK3R4 | 0.753111 | 11 | 0 | 11 |
| HLTF | ARHGAP24 | 0.753057 | 3 | 0 | 3 |
| HLTF | PRR12 | 0.752347 | 3 | 0 | 3 |
| HLTF | STAT5B | 0.752197 | 3 | 0 | 3 |
| HLTF | VEZF1 | 0.751325 | 6 | 0 | 6 |
| HLTF | XRN1 | 0.75094 | 3 | 0 | 3 |
| HLTF | SSBP4 | 0.75026 | 4 | 0 | 4 |
For details and further investigation, click here
