| Full name: homeobox containing 1 | Alias Symbol: HNF1LA|PBHNF|FLJ21616|HOT1 | ||
| Type: protein-coding gene | Cytoband: 8p21.1-p12 | ||
| Entrez ID: 79618 | HGNC ID: HGNC:26137 | Ensembl Gene: ENSG00000147421 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of HMBOX1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HMBOX1 | 79618 | 219269_at | 0.4217 | 0.1022 | |
| GSE20347 | HMBOX1 | 79618 | 219269_at | 0.1905 | 0.2426 | |
| GSE23400 | HMBOX1 | 79618 | 219269_at | 0.0572 | 0.3084 | |
| GSE26886 | HMBOX1 | 79618 | 219269_at | 0.2788 | 0.2899 | |
| GSE29001 | HMBOX1 | 79618 | 219269_at | 0.0409 | 0.9079 | |
| GSE38129 | HMBOX1 | 79618 | 219269_at | -0.1941 | 0.2078 | |
| GSE45670 | HMBOX1 | 79618 | 219269_at | -0.2830 | 0.2554 | |
| GSE53622 | HMBOX1 | 79618 | 70193 | -0.3249 | 0.0001 | |
| GSE53624 | HMBOX1 | 79618 | 70193 | -0.1440 | 0.0106 | |
| GSE63941 | HMBOX1 | 79618 | 219269_at | -0.6671 | 0.2629 | |
| GSE77861 | HMBOX1 | 79618 | 219269_at | 0.2304 | 0.2946 | |
| GSE97050 | HMBOX1 | 79618 | A_23_P134684 | -0.2450 | 0.3291 | |
| SRP007169 | HMBOX1 | 79618 | RNAseq | 0.5545 | 0.1988 | |
| SRP008496 | HMBOX1 | 79618 | RNAseq | 0.4751 | 0.1830 | |
| SRP064894 | HMBOX1 | 79618 | RNAseq | 0.4357 | 0.0913 | |
| SRP133303 | HMBOX1 | 79618 | RNAseq | -0.2728 | 0.2067 | |
| SRP159526 | HMBOX1 | 79618 | RNAseq | -0.2655 | 0.4789 | |
| SRP193095 | HMBOX1 | 79618 | RNAseq | 0.0438 | 0.7154 | |
| SRP219564 | HMBOX1 | 79618 | RNAseq | -0.1920 | 0.6786 | |
| TCGA | HMBOX1 | 79618 | RNAseq | -0.2130 | 0.0102 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by HMBOX1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HMBOX1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HMBOX1 | 79618 | 4 | 10 | 16 | |
| GSE20123 | HMBOX1 | 79618 | 4 | 10 | 16 | |
| GSE43470 | HMBOX1 | 79618 | 4 | 7 | 32 | |
| GSE46452 | HMBOX1 | 79618 | 13 | 13 | 33 | |
| GSE47630 | HMBOX1 | 79618 | 10 | 8 | 22 | |
| GSE54993 | HMBOX1 | 79618 | 2 | 15 | 53 | |
| GSE54994 | HMBOX1 | 79618 | 10 | 15 | 28 | |
| GSE60625 | HMBOX1 | 79618 | 3 | 0 | 8 | |
| GSE74703 | HMBOX1 | 79618 | 4 | 6 | 26 | |
| GSE74704 | HMBOX1 | 79618 | 3 | 7 | 10 | |
| TCGA | HMBOX1 | 79618 | 18 | 41 | 37 |
Total number of gains: 75; Total number of losses: 132; Total Number of normals: 281.
Somatic mutations of HMBOX1:
Generating mutation plots.
Highly correlated genes for HMBOX1:
Showing top 20/138 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HMBOX1 | HLTF | 0.839395 | 3 | 0 | 3 |
| HMBOX1 | MED9 | 0.821085 | 3 | 0 | 3 |
| HMBOX1 | C20orf27 | 0.807526 | 3 | 0 | 3 |
| HMBOX1 | XRN1 | 0.799145 | 3 | 0 | 3 |
| HMBOX1 | SRC | 0.797107 | 3 | 0 | 3 |
| HMBOX1 | ADNP | 0.784036 | 3 | 0 | 3 |
| HMBOX1 | FXR1 | 0.780016 | 3 | 0 | 3 |
| HMBOX1 | NONO | 0.763811 | 3 | 0 | 3 |
| HMBOX1 | DDX55 | 0.756399 | 3 | 0 | 3 |
| HMBOX1 | ARHGEF11 | 0.751748 | 3 | 0 | 3 |
| HMBOX1 | RIOK1 | 0.751587 | 3 | 0 | 3 |
| HMBOX1 | CAMKK2 | 0.75044 | 3 | 0 | 3 |
| HMBOX1 | LRRC58 | 0.749693 | 3 | 0 | 3 |
| HMBOX1 | FXR2 | 0.746104 | 3 | 0 | 3 |
| HMBOX1 | PNPLA6 | 0.740427 | 3 | 0 | 3 |
| HMBOX1 | TAPBP | 0.729114 | 3 | 0 | 3 |
| HMBOX1 | EIF2B5 | 0.719919 | 3 | 0 | 3 |
| HMBOX1 | MED30 | 0.719439 | 3 | 0 | 3 |
| HMBOX1 | PIP5K1C | 0.718904 | 3 | 0 | 3 |
| HMBOX1 | LMLN | 0.71757 | 3 | 0 | 3 |
For details and further investigation, click here
