| Full name: GABA type A receptor associated protein like 2 | Alias Symbol: GEF2|ATG8|GATE16|GATE-16|ATG8C | ||
| Type: protein-coding gene | Cytoband: 16q23.1 | ||
| Entrez ID: 11345 | HGNC ID: HGNC:13291 | Ensembl Gene: ENSG00000034713 | OMIM ID: 607452 |
| Drug and gene relationship at DGIdb | |||
GABARAPL2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04068 | FoxO signaling pathway |
Expression of GABARAPL2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GABARAPL2 | 11345 | 209046_s_at | -0.2398 | 0.6489 | |
| GSE20347 | GABARAPL2 | 11345 | 209046_s_at | -0.4868 | 0.0181 | |
| GSE23400 | GABARAPL2 | 11345 | 209046_s_at | -0.3835 | 0.0000 | |
| GSE26886 | GABARAPL2 | 11345 | 209046_s_at | -1.1469 | 0.0000 | |
| GSE29001 | GABARAPL2 | 11345 | 209046_s_at | -0.5973 | 0.0194 | |
| GSE38129 | GABARAPL2 | 11345 | 209046_s_at | -0.4230 | 0.0150 | |
| GSE45670 | GABARAPL2 | 11345 | 209046_s_at | -0.3460 | 0.0015 | |
| GSE53622 | GABARAPL2 | 11345 | 131551 | -0.4199 | 0.0000 | |
| GSE53624 | GABARAPL2 | 11345 | 131551 | -0.6759 | 0.0000 | |
| GSE63941 | GABARAPL2 | 11345 | 209046_s_at | -0.0044 | 0.9911 | |
| GSE77861 | GABARAPL2 | 11345 | 209046_s_at | -0.3850 | 0.1346 | |
| GSE97050 | GABARAPL2 | 11345 | A_24_P356338 | -0.2504 | 0.2677 | |
| SRP007169 | GABARAPL2 | 11345 | RNAseq | -1.9674 | 0.0000 | |
| SRP008496 | GABARAPL2 | 11345 | RNAseq | -1.6619 | 0.0000 | |
| SRP064894 | GABARAPL2 | 11345 | RNAseq | -0.7764 | 0.0000 | |
| SRP133303 | GABARAPL2 | 11345 | RNAseq | -0.1139 | 0.5092 | |
| SRP159526 | GABARAPL2 | 11345 | RNAseq | -0.2524 | 0.3760 | |
| SRP193095 | GABARAPL2 | 11345 | RNAseq | -0.8472 | 0.0000 | |
| SRP219564 | GABARAPL2 | 11345 | RNAseq | -0.6163 | 0.1257 | |
| TCGA | GABARAPL2 | 11345 | RNAseq | -0.0679 | 0.1656 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by GABARAPL2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GABARAPL2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GABARAPL2 | 11345 | 5 | 0 | 25 | |
| GSE20123 | GABARAPL2 | 11345 | 5 | 0 | 25 | |
| GSE43470 | GABARAPL2 | 11345 | 2 | 7 | 34 | |
| GSE46452 | GABARAPL2 | 11345 | 37 | 2 | 20 | |
| GSE47630 | GABARAPL2 | 11345 | 11 | 8 | 21 | |
| GSE54993 | GABARAPL2 | 11345 | 2 | 4 | 64 | |
| GSE54994 | GABARAPL2 | 11345 | 8 | 10 | 35 | |
| GSE60625 | GABARAPL2 | 11345 | 4 | 0 | 7 | |
| GSE74703 | GABARAPL2 | 11345 | 2 | 5 | 29 | |
| GSE74704 | GABARAPL2 | 11345 | 2 | 0 | 18 | |
| TCGA | GABARAPL2 | 11345 | 24 | 15 | 57 |
Total number of gains: 102; Total number of losses: 51; Total Number of normals: 335.
Somatic mutations of GABARAPL2:
Generating mutation plots.
Highly correlated genes for GABARAPL2:
Showing top 20/1226 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GABARAPL2 | CCNYL1 | 0.770815 | 3 | 0 | 3 |
| GABARAPL2 | UBE4A | 0.745601 | 3 | 0 | 3 |
| GABARAPL2 | AIDA | 0.741333 | 3 | 0 | 3 |
| GABARAPL2 | HNRNPH2 | 0.723933 | 3 | 0 | 3 |
| GABARAPL2 | ANKRD13A | 0.71587 | 7 | 0 | 7 |
| GABARAPL2 | ACRBP | 0.714255 | 3 | 0 | 3 |
| GABARAPL2 | PSMC3 | 0.708285 | 3 | 0 | 3 |
| GABARAPL2 | CCNDBP1 | 0.70757 | 8 | 0 | 8 |
| GABARAPL2 | CNN3 | 0.706363 | 9 | 0 | 9 |
| GABARAPL2 | ZNF555 | 0.70598 | 6 | 0 | 6 |
| GABARAPL2 | PDIK1L | 0.703038 | 3 | 0 | 3 |
| GABARAPL2 | SREBF2 | 0.700377 | 3 | 0 | 3 |
| GABARAPL2 | PCBP1-AS1 | 0.697693 | 3 | 0 | 3 |
| GABARAPL2 | CTTNBP2NL | 0.696695 | 8 | 0 | 8 |
| GABARAPL2 | ZNF416 | 0.69603 | 4 | 0 | 3 |
| GABARAPL2 | SYTL4 | 0.693969 | 4 | 0 | 4 |
| GABARAPL2 | CNST | 0.693304 | 5 | 0 | 4 |
| GABARAPL2 | TAB3 | 0.692831 | 6 | 0 | 6 |
| GABARAPL2 | RBM20 | 0.689514 | 4 | 0 | 4 |
| GABARAPL2 | IREB2 | 0.687655 | 3 | 0 | 3 |
For details and further investigation, click here
