| Full name: iron responsive element binding protein 2 | Alias Symbol: IRP2 | ||
| Type: protein-coding gene | Cytoband: 15q25.1 | ||
| Entrez ID: 3658 | HGNC ID: HGNC:6115 | Ensembl Gene: ENSG00000136381 | OMIM ID: 147582 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of IREB2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IREB2 | 3658 | 225892_at | 0.0840 | 0.9297 | |
| GSE20347 | IREB2 | 3658 | 214666_x_at | -0.1035 | 0.4263 | |
| GSE23400 | IREB2 | 3658 | 214666_x_at | -0.0039 | 0.8711 | |
| GSE26886 | IREB2 | 3658 | 225892_at | -0.4595 | 0.2154 | |
| GSE29001 | IREB2 | 3658 | 214666_x_at | -0.1136 | 0.2821 | |
| GSE38129 | IREB2 | 3658 | 214666_x_at | 0.0068 | 0.9667 | |
| GSE45670 | IREB2 | 3658 | 225892_at | -0.1416 | 0.3001 | |
| GSE53622 | IREB2 | 3658 | 70329 | 0.1427 | 0.0217 | |
| GSE53624 | IREB2 | 3658 | 70329 | -0.1483 | 0.0024 | |
| GSE63941 | IREB2 | 3658 | 225892_at | -0.6081 | 0.1574 | |
| GSE77861 | IREB2 | 3658 | 225892_at | -0.0154 | 0.9740 | |
| GSE97050 | IREB2 | 3658 | A_33_P3221528 | -0.2382 | 0.3192 | |
| SRP007169 | IREB2 | 3658 | RNAseq | 0.0335 | 0.9200 | |
| SRP008496 | IREB2 | 3658 | RNAseq | 0.2710 | 0.2725 | |
| SRP064894 | IREB2 | 3658 | RNAseq | -0.4683 | 0.0349 | |
| SRP133303 | IREB2 | 3658 | RNAseq | 0.0324 | 0.8388 | |
| SRP159526 | IREB2 | 3658 | RNAseq | 0.1754 | 0.4612 | |
| SRP193095 | IREB2 | 3658 | RNAseq | -0.0345 | 0.6257 | |
| SRP219564 | IREB2 | 3658 | RNAseq | -0.1902 | 0.6083 | |
| TCGA | IREB2 | 3658 | RNAseq | -0.0418 | 0.3677 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by IREB2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IREB2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IREB2 | 3658 | 7 | 1 | 22 | |
| GSE20123 | IREB2 | 3658 | 7 | 1 | 22 | |
| GSE43470 | IREB2 | 3658 | 4 | 5 | 34 | |
| GSE46452 | IREB2 | 3658 | 3 | 7 | 49 | |
| GSE47630 | IREB2 | 3658 | 8 | 10 | 22 | |
| GSE54993 | IREB2 | 3658 | 5 | 6 | 59 | |
| GSE54994 | IREB2 | 3658 | 5 | 6 | 42 | |
| GSE60625 | IREB2 | 3658 | 4 | 0 | 7 | |
| GSE74703 | IREB2 | 3658 | 4 | 3 | 29 | |
| GSE74704 | IREB2 | 3658 | 3 | 1 | 16 | |
| TCGA | IREB2 | 3658 | 14 | 15 | 67 |
Total number of gains: 64; Total number of losses: 55; Total Number of normals: 369.
Somatic mutations of IREB2:
Generating mutation plots.
Highly correlated genes for IREB2:
Showing top 20/369 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IREB2 | PEX2 | 0.829942 | 3 | 0 | 3 |
| IREB2 | GMCL1 | 0.81278 | 3 | 0 | 3 |
| IREB2 | SIKE1 | 0.779822 | 3 | 0 | 3 |
| IREB2 | AAGAB | 0.7771 | 3 | 0 | 3 |
| IREB2 | SENP8 | 0.775962 | 3 | 0 | 3 |
| IREB2 | RBAK | 0.769987 | 4 | 0 | 4 |
| IREB2 | CRIM1 | 0.760866 | 3 | 0 | 3 |
| IREB2 | NNT | 0.758296 | 3 | 0 | 3 |
| IREB2 | PLBD1 | 0.744395 | 3 | 0 | 3 |
| IREB2 | UBE2Q2 | 0.743074 | 3 | 0 | 3 |
| IREB2 | NR2C2 | 0.741331 | 4 | 0 | 4 |
| IREB2 | MAGEF1 | 0.738504 | 3 | 0 | 3 |
| IREB2 | DPY19L3 | 0.734547 | 3 | 0 | 3 |
| IREB2 | TMTC3 | 0.728811 | 4 | 0 | 3 |
| IREB2 | CRNKL1 | 0.726215 | 3 | 0 | 3 |
| IREB2 | PPFIBP2 | 0.724554 | 3 | 0 | 3 |
| IREB2 | SLC30A6 | 0.721875 | 4 | 0 | 3 |
| IREB2 | C12orf66 | 0.720387 | 4 | 0 | 4 |
| IREB2 | CHUK | 0.718002 | 3 | 0 | 3 |
| IREB2 | IDH3A | 0.717786 | 3 | 0 | 3 |
For details and further investigation, click here
