| Full name: ubiquitination factor E4A | Alias Symbol: UBOX2|UFD2|KIAA0126|E4 | ||
| Type: protein-coding gene | Cytoband: 11q23.3 | ||
| Entrez ID: 9354 | HGNC ID: HGNC:12499 | Ensembl Gene: ENSG00000110344 | OMIM ID: 603753 |
| Drug and gene relationship at DGIdb | |||
Expression of UBE4A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | UBE4A | 9354 | 202038_at | -0.1636 | 0.4375 | |
| GSE20347 | UBE4A | 9354 | 202038_at | -0.3511 | 0.0022 | |
| GSE23400 | UBE4A | 9354 | 202038_at | -0.2195 | 0.0035 | |
| GSE26886 | UBE4A | 9354 | 202038_at | 0.0551 | 0.8749 | |
| GSE29001 | UBE4A | 9354 | 202038_at | -0.3558 | 0.1268 | |
| GSE38129 | UBE4A | 9354 | 202038_at | -0.3290 | 0.0002 | |
| GSE45670 | UBE4A | 9354 | 202038_at | -0.2227 | 0.0217 | |
| GSE63941 | UBE4A | 9354 | 202038_at | -1.1965 | 0.0044 | |
| GSE77861 | UBE4A | 9354 | 202038_at | 0.0739 | 0.7972 | |
| GSE97050 | UBE4A | 9354 | A_23_P203137 | -0.1369 | 0.4990 | |
| SRP007169 | UBE4A | 9354 | RNAseq | -0.4567 | 0.2162 | |
| SRP008496 | UBE4A | 9354 | RNAseq | -0.2871 | 0.2677 | |
| SRP064894 | UBE4A | 9354 | RNAseq | -0.3659 | 0.0274 | |
| SRP133303 | UBE4A | 9354 | RNAseq | -0.2797 | 0.0043 | |
| SRP159526 | UBE4A | 9354 | RNAseq | -0.6640 | 0.0215 | |
| SRP193095 | UBE4A | 9354 | RNAseq | -0.6073 | 0.0000 | |
| SRP219564 | UBE4A | 9354 | RNAseq | -0.5773 | 0.0348 | |
| TCGA | UBE4A | 9354 | RNAseq | -0.2201 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by UBE4A expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of UBE4A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | UBE4A | 9354 | 2 | 11 | 17 | |
| GSE20123 | UBE4A | 9354 | 2 | 11 | 17 | |
| GSE43470 | UBE4A | 9354 | 2 | 9 | 32 | |
| GSE46452 | UBE4A | 9354 | 3 | 26 | 30 | |
| GSE47630 | UBE4A | 9354 | 2 | 19 | 19 | |
| GSE54993 | UBE4A | 9354 | 10 | 0 | 60 | |
| GSE54994 | UBE4A | 9354 | 5 | 19 | 29 | |
| GSE60625 | UBE4A | 9354 | 0 | 3 | 8 | |
| GSE74703 | UBE4A | 9354 | 1 | 6 | 29 | |
| GSE74704 | UBE4A | 9354 | 1 | 7 | 12 | |
| TCGA | UBE4A | 9354 | 5 | 50 | 41 |
Total number of gains: 33; Total number of losses: 161; Total Number of normals: 294.
Somatic mutations of UBE4A:
Generating mutation plots.
Highly correlated genes for UBE4A:
Showing top 20/537 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| UBE4A | NTAN1 | 0.796219 | 3 | 0 | 3 |
| UBE4A | SMU1 | 0.766094 | 3 | 0 | 3 |
| UBE4A | MITD1 | 0.758669 | 4 | 0 | 4 |
| UBE4A | S100PBP | 0.749467 | 3 | 0 | 3 |
| UBE4A | GABARAPL2 | 0.745601 | 3 | 0 | 3 |
| UBE4A | BRK1 | 0.742444 | 4 | 0 | 3 |
| UBE4A | UBR3 | 0.741521 | 3 | 0 | 3 |
| UBE4A | COPS6 | 0.740832 | 3 | 0 | 3 |
| UBE4A | C20orf194 | 0.727544 | 3 | 0 | 3 |
| UBE4A | CLIP4 | 0.723085 | 3 | 0 | 3 |
| UBE4A | INSIG1 | 0.72071 | 3 | 0 | 3 |
| UBE4A | C11orf54 | 0.719802 | 3 | 0 | 3 |
| UBE4A | CYP27A1 | 0.717527 | 3 | 0 | 3 |
| UBE4A | ICK | 0.716989 | 3 | 0 | 3 |
| UBE4A | NHS | 0.712801 | 3 | 0 | 3 |
| UBE4A | INTS12 | 0.712705 | 3 | 0 | 3 |
| UBE4A | CTTNBP2NL | 0.710825 | 4 | 0 | 3 |
| UBE4A | PMPCB | 0.709829 | 3 | 0 | 3 |
| UBE4A | CHMP5 | 0.709059 | 4 | 0 | 3 |
| UBE4A | ZDHHC3 | 0.709057 | 4 | 0 | 3 |
For details and further investigation, click here
