| Full name: sterol regulatory element binding transcription factor 2 | Alias Symbol: SREBP2|bHLHd2 | ||
| Type: protein-coding gene | Cytoband: 22q13.2 | ||
| Entrez ID: 6721 | HGNC ID: HGNC:11290 | Ensembl Gene: ENSG00000198911 | OMIM ID: 600481 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of SREBF2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SREBF2 | 6721 | 201247_at | -0.0749 | 0.8838 | |
| GSE20347 | SREBF2 | 6721 | 201247_at | -0.4043 | 0.0015 | |
| GSE23400 | SREBF2 | 6721 | 201248_s_at | -0.1943 | 0.0143 | |
| GSE26886 | SREBF2 | 6721 | 201247_at | -0.5232 | 0.0001 | |
| GSE29001 | SREBF2 | 6721 | 201248_s_at | -0.1682 | 0.4668 | |
| GSE38129 | SREBF2 | 6721 | 201247_at | -0.2959 | 0.0494 | |
| GSE45670 | SREBF2 | 6721 | 242748_at | 0.1959 | 0.1515 | |
| GSE53622 | SREBF2 | 6721 | 22425 | -0.8418 | 0.0000 | |
| GSE53624 | SREBF2 | 6721 | 22425 | -0.5132 | 0.0000 | |
| GSE63941 | SREBF2 | 6721 | 201247_at | 1.1872 | 0.0079 | |
| GSE77861 | SREBF2 | 6721 | 201247_at | -0.1555 | 0.3685 | |
| GSE97050 | SREBF2 | 6721 | A_23_P419602 | 0.0643 | 0.7834 | |
| SRP007169 | SREBF2 | 6721 | RNAseq | -0.4074 | 0.1638 | |
| SRP008496 | SREBF2 | 6721 | RNAseq | -0.7339 | 0.0013 | |
| SRP064894 | SREBF2 | 6721 | RNAseq | -0.2810 | 0.1556 | |
| SRP133303 | SREBF2 | 6721 | RNAseq | -0.6315 | 0.0292 | |
| SRP159526 | SREBF2 | 6721 | RNAseq | -0.1947 | 0.1689 | |
| SRP193095 | SREBF2 | 6721 | RNAseq | -0.3285 | 0.0106 | |
| SRP219564 | SREBF2 | 6721 | RNAseq | -0.6463 | 0.1016 | |
| TCGA | SREBF2 | 6721 | RNAseq | -0.0683 | 0.1728 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by SREBF2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SREBF2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SREBF2 | 6721 | 6 | 5 | 19 | |
| GSE20123 | SREBF2 | 6721 | 6 | 4 | 20 | |
| GSE43470 | SREBF2 | 6721 | 5 | 6 | 32 | |
| GSE46452 | SREBF2 | 6721 | 31 | 2 | 26 | |
| GSE47630 | SREBF2 | 6721 | 9 | 4 | 27 | |
| GSE54993 | SREBF2 | 6721 | 3 | 6 | 61 | |
| GSE54994 | SREBF2 | 6721 | 11 | 8 | 34 | |
| GSE60625 | SREBF2 | 6721 | 5 | 0 | 6 | |
| GSE74703 | SREBF2 | 6721 | 5 | 4 | 27 | |
| GSE74704 | SREBF2 | 6721 | 3 | 2 | 15 | |
| TCGA | SREBF2 | 6721 | 27 | 14 | 55 |
Total number of gains: 111; Total number of losses: 55; Total Number of normals: 322.
Somatic mutations of SREBF2:
Generating mutation plots.
Highly correlated genes for SREBF2:
Showing top 20/861 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SREBF2 | RAB8A | 0.785958 | 3 | 0 | 3 |
| SREBF2 | MTA3 | 0.766308 | 3 | 0 | 3 |
| SREBF2 | VCP | 0.764222 | 3 | 0 | 3 |
| SREBF2 | SLC13A2 | 0.762724 | 3 | 0 | 3 |
| SREBF2 | LRRC28 | 0.758806 | 3 | 0 | 3 |
| SREBF2 | RBPJL | 0.75582 | 4 | 0 | 4 |
| SREBF2 | ZNF747 | 0.744724 | 3 | 0 | 3 |
| SREBF2 | POLE3 | 0.737495 | 3 | 0 | 3 |
| SREBF2 | ATXN3L | 0.735111 | 3 | 0 | 3 |
| SREBF2 | FRAT1 | 0.732606 | 3 | 0 | 3 |
| SREBF2 | IER3IP1 | 0.729471 | 3 | 0 | 3 |
| SREBF2 | SFRP5 | 0.728017 | 3 | 0 | 3 |
| SREBF2 | FBXO8 | 0.727433 | 3 | 0 | 3 |
| SREBF2 | C2orf16 | 0.726386 | 3 | 0 | 3 |
| SREBF2 | PANK1 | 0.726122 | 3 | 0 | 3 |
| SREBF2 | PRPSAP1 | 0.724109 | 3 | 0 | 3 |
| SREBF2 | RNF207 | 0.723854 | 3 | 0 | 3 |
| SREBF2 | MARS2 | 0.723334 | 3 | 0 | 3 |
| SREBF2 | R3HDM2 | 0.722271 | 3 | 0 | 3 |
| SREBF2 | PRKAG1 | 0.721151 | 4 | 0 | 4 |
For details and further investigation, click here
